Genotoxic potential of leaf extracts of Jatropha gossypiifolia L.
Authors: P.M. Almeida1,2, S.S. Ara�ºjo1, I.R.M.R. Santos1, M.A. Marin-Morales3,A.M. Benko-Iseppon1, A.V. Santos4, K.P. Randau4 and A.C. Brasileiro-Vidal1
Jatropha gossypiifolia L. (Euphorbiaceae) is widely used in popular medicine. However, further toxicological studies are necessary for its reliable use. The present study aimed to evaluate the cytotoxic, genotoxic, and mutagenic effects of ethanolic and aqueous leaf extracts of J. gossypiifolia, using the test system Allium cepa. In addition, the phytoche.. Read More»
- Genet. Mol. Res. 15(1):
- 0.4238/gmr.15017415
- DOI:
- 0.4238/gmr.15017415
A genome-wide association study of growth trait-related single nucleotide polymorphisms in Chinese Yancheng chickens
Authors: C.F. Jin, Y.J. Chen, Z.Q. Yang, K. Shi, C.K. Chen
Chicken (Gallus gallus) growth traits are important economic traits, and many studies have been conducted on genetic selection for body weight. However, most of these studies have detected functional chromosome mutations or regions by conventional molecular markers or gene chips. In this study, we performed a new genome-wide a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.30
- DOI:
- 10.4238/2015.December.1.30
Genotypic variability for root/shoot parameters under water stress in some advanced lines of cotton (Gossypium hirsutum L.)
Authors: M. Riaz J. Farooq G. Sakhawat A. Mahmood M.A. Sadiq M. Yaseen
Research pertaining to genetic variability parameters, heritability, and genotypic, phenotypic, simple, and environmental correlations for various seedling traits in five elite advanced cotton (Gossypium hirsutum L.) lines (FH-113, FH-114, FH-941, FH-942, and FH-2015) and one check (CIM-496) was carried out during October and November 2010 under greenhous.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.4
- DOI:
- 10.4238/2013.February.27.4
Identification and characterization of TGF�²-dependent and -independent cis-regulatory modules in the C4ST-1/CHST11 locus
Authors: C.M. Willis, J.L. Wrana and M. Kl�¼ppel
Chondroitin-4-sulfotransferase-1(C4ST-1)/carbohydrate sulfotransferase 11 (CHST11) is a Golgi-bound enzyme involved in the biosynthesis of the glycosaminoglycan chondroitin sulfate. The sulfation pattern of chondroitin is tightly regulated during development, injury and disease, with the temporal and spatial expressi.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr673
- DOI:
- 10.4238/vol8-4gmr673
Single nucleotide polymorphisms in the CNTNAP2 gene in Brazilian patients with autistic spectrum disorder
Authors: P.P. Nascimento1, A.L. Bossolani-Martins2, D.B.A. Rosan1, L.C. Mattos3,C. Brand�£o-Mattos3 and A.C. Fett-Conte3
The role of some genes and their single nucleotide polymorphisms (SNPs) as genetic contributors of complex diseases is still a topic of much investigation. Research on genes related to autism susceptibility has been somewhat challenging, but also promising. Common genomic variants of CNTNAP2 have been associated with autism, and a range of autistic phenot.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017422
- DOI:
- 10.4238/gmr.15017422
Genetic study of meat quality traits in a male broiler line
Authors: L.G. Gaya
-.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4ta026
- DOI:
- 10.4238/vol8-4ta026
More severe clinical course of cardiovascular dysfunction in intensive care unit patients with the 894TT eNOS genotype
Authors: L.R. Fraga F.J.O. Paludo A.J.G. B�³s J.L.S. Ferraro F.S. Dias C.S. Alho
The endothelial nitric oxide synthase (eNOS) plays an important homeostatic role in the cardiovascular system (CVS) by maintaining appropriate blood pressure through production of nitric oxide. The 894TT genotype of 894G>T (Glu298Asp, rs1799983), a polymorphic variant of eNOS, has been associated with several vascular diseases. On the basis of this str.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.5
- DOI:
- 10.4238/2013.February.27.5
Lipid peroxidation and antioxidant capacity of G6PD-deficient patients with A-(202G>A) mutation
Authors: L.S. Ondei, L.M. Silveira, A.A. Leite, D.R.S. Souza,M.A.S. Pinhel, S. Perc�¡rio, O. Ricci J�ºnior and C.R. Bonini-Domingos
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage. We evaluated G6PD activity, oxidative stress levels and Trolox equivalent antioxidant capacity in individuals with the A-(202G>A) mutation for G6PD deficiency. Five h.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr662
- DOI:
- 10.4238/vol8-4gmr662
Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents
Authors: H.W. Liu, R.Y. Xu, R.P. Sun, Q. Wang, J.L. Liu, W. Ge1and Z. Yu
Previous studies have indicated that the protein tyrosine phosphatase nonreceptor type 22 gene (PTPN22) is associated with type 1 diabetes (T1DM) in the Caucasian population. In the present study, we investigated the relationship between PTPN22 genetic polymorphisms and T1DM in Chinese children. A total of 202 children and adolescents with T1DM and 240 he.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.8
- DOI:
- 10.4238/2015.January.15.8
Genetic diversity and mating system of Copaifera langsdorffii (Leguminosae/Caesalpinioideae)
Authors: A. Gonela A.M. Sebbenn H.H. Soriani M.A. Mestriner C.A. Martinez A.L. Alzate-Marin
Copaifera langsdorffii, locally known as copaÃ?Âba, is a valuable tropical tree with medicinal properties of its oil. We studied the genetic variation, genetic structure, and the mating system of trees in stands of C. langsdorffii (Leguminosae/Caesalpinioideae) located in an extensive area between the Pardo and Mogi-GuaÃ?§u basins in SÃ?£o Paulo State, Br.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.6
- DOI:
- 10.4238/2013.February.27.6