Genetic variability of XRCC1 influences the treatment outcome of gastric cancer
Authors: H.Q. Hu1, F. Wang2, X. Du2, X.Z. Zhao2, Z. Jin2 and M.X. Hou2
We aimed to investigate the role of XRCC1 codon 194 (Arg>Trp), 280 (Arg>His), and 399 (Arg>Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients. A total of 172 patients were recruited for our study between January 2010 and March 2012. Genotyping of the three XRCC1 codons was carried out by restriction.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017452
- DOI:
- 10.4238/gmr.15017452
Coconut genome size determined by flow cytometry: Tall versus Dwarf types
Authors: M. Freitas Neto1, T.N.S. Pereira1, I.G.C. Geronimo1, A.O.N. Azevedo1,S.R.R. Ramos2 and M.G. Pereira1
Coconuts (Cocos nucifera L.) are tropical palm trees that are classified into Tall and Dwarf types based on height, and both types are diploid (2n = 2x = 32 chromosomes). The reproduction mode is autogamous for Dwarf types and allogamous for Tall types. One hypothesis for the origin of the Dwarf coconut suggests that it is a Tall variant that resulted fro.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017470
- DOI:
- 10.4238/gmr.15017470
P2X7 receptor in the hippocampus is involved in gp120-induced cognitive dysfunction
Authors: Y. Liu, G.Q. Chen, B.Y. Liu, Q. Chen, Y.M. Qian, S.S. Qin, C.L. Liu and C.S. Xu
To investigate the role of the P2X7 receptor in learning and memory dysfunction induced by HIV-1 envelope glycoprotein gp120 (gp120), we established HIV-1-associated dementia (HAD) animal models by intracerebroventricular (ICV) infusion of gp120 in rats. We observed gp120-induced cognitive dysfunction in the radial arm water m.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019356
- DOI:
- 10.4238/gmr16019356
Diversity and genetic structure among subpopulations of Gossypium mustelinum (Malvaceae)
Authors: M.F. Alves P.A.V. Barroso A.Y. Ciampi L.V. Hoffmann V.C.R. Azevedo U. Cavalcante
Gossypium mustelinum is the only cotton species native to Brazil; it is endemic to the semi-arid region of the northeast. The populations are found near perennial and semi-perennial sources of water, such as ponds or pools in intermittent streams. Problems with in situ conservation derive from human interference in its habitat, mainly because of excessive.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.9
- DOI:
- 10.4238/2013.February.27.9
Construction and transformation of expression vector containing Panax japonicus SS gene
Authors: L. Zhang and T.T. Wang
Panax japonicus C.A. Meyer, a perennial herb belonging to the Araliaceae ginseng genus, is one of the seven rare and endangered Chinese medical herbs. By cloning the SS segment, the expression vectors pCXSN-PjSS and pCXSN-antiPjSS were constructed and introduced into Agrobactria LBA4404, which is used for engineering bacteria... Read More»
- Genet. Mol. Res. 16(1):
- gmr16019341
- DOI:
- 10.4238/gmr16019341
Synthesis of periclinal chimera in cassava
Authors: N.M.A. Nassar N. Bomfim
We provide the first report on the synthesis of a very productive interspecific periclinal chimera of cassava, with large and edible roots. The epidermal tissue of the chimera was formed by the cultivated species Manihot esculenta (E), and the subepidermis and internal tissue were formed by the wild species, Manihot fortalezensis (F). We used cytogenetics an.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.27.10
- DOI:
- 10.4238/2013.February.27.10
Manipulation of components that control feeding behavior in Drosophila melanogaster increases sensitivity to amino acid starvation
Authors: J.D. Slade and B.E. Staveley
Feeding is a complex behavior that is regulated by several internal mechanisms. Neuropeptides are able to survey quantities of stored energy and inform the organism if nutrient intake is required. In addition to this homeostatic regulation, a post-feeding reward system positively reinforces feeding. Slight adjustments to either system can tilt the balance.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017489
- DOI:
- 10.4238/gmr.15017489
Analysis of the genetic diversity of Lonicera japonica Thumb. using inter-simple sequence repeat markers
Authors: H.Y. He, D. Zhang, H. Qing and Y. Yang
Inter-simple sequence repeats (ISSRs) were used to analyze the genetic diversity of 21 accessions obtained from four provinces in China, Shandong, Henan, Hebei, and Sichuan. A total of 272 scored bands were generated using the eight primers previously screened across 21 accessions, of which 267 were polymorphic (98.16%). Genet.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019338
- DOI:
- 10.4238/gmr16019338
Characterization of chicken natural resistance-associated macrophage protein encoding genes (Nramp1 and Nramp2) and association with salmonellosis resistance
Authors: X.M. He M.X. Fang Z.T. Zhang Y.S. Hu X.Z. Jia D.L. He S.D. Liang Q.H. Nie X.Q. Zhang
Natural resistance-associated macrophage protein 1 and 2 encoding genes (Nramp1 and Nramp2) are related to many diseases. We cloned the cDNA of chicken Nramp1 and Nramp2 genes, characterized their expression and polymorphisms, and investigated the association of some SNPs with resistance to salmonellosis. The Nramp1 cDNA was 1746 bp long and the Nramp2 cD.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.30.5
- DOI:
- 10.4238/2013.January.30.5
Estrogenic effects of flavonoid components in Xiaoyao powder
Authors: J.H. Chen1, N. Zhang1, Y.Q. Wang1, J.Z. Wang1, S.X. Ji1, W.J. Dang1, S.M. Li2 and L. Feng2
The objective of this study was to evaluate the estrogenic effects and mechanisms of three flavonoid components in Xiaoyao powder: quercetin, kaempferol, and isorhamnetin. The drugs were used to treat estrogen receptor (ER)-positive human breast cancer MCF-7 cells, and proliferation was measured using the MTT method. The expression of proteins and mRNA of.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017500
- DOI:
- 10.4238/gmr.15017500