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Human Genetics   Research Article
Development of a polymorphic short tandem repeat locus multiplex system for efficient human identification

Authors: R.G. Rodovalho, E.L. Rodrigues, G.S. Santos, L.M. Cavalcanti,P.R. Lima, A.G. Rodovalho, R.G. Vital, M.A.D. Gigonzac and A.D. da Cruz

This study aimed to develop a short tandem repeat (STR) multiplex system, made up of 22 highly informative STR loci, for application in forensic genetics. The system comprised 21 polymorphic autosomal loci (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX, FGA, D2S44.. Read More»

Genet. Mol. Res. 16(2): gmr16029557

DOI: 10.4238/gmr16029557

Plant Genetics   Research Article
Analysis of allopolyploidy-induced rapid genetic and epigenetic changes and their relationship in wheat

Authors: T. Qiu, Y.Z. Dong, X.M. Yu, N. Zhao and Y.F. Yang

We used the conventional and methylation-sensitive randomly amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR) analyses to assess genome-wide changes and explore the relationships between genetic and epigenetic variations among individuals of a newly synthesized allohexaploid wheat line whose genomic cons.. Read More»

Genet. Mol. Res. 16(2): gmr16029303

DOI: 10.4238/gmr16029303

Human Genetics   Research Article
Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women

Authors: J. Chen, M. Zhong and Y.H. Yu

Preeclampsia is a common disease unique to pregnant women, and its development involves many genetics l factors. IL-4 is an important regulatory factor of the Th2 cellular immune response, and plays an important role in the induction of placental growth. In this study, we investigated the relationship between IL-4 C-590T, C+33.. Read More»

Genet. Mol. Res. 16(2): gmr16029218

DOI: 10.4238/gmr16029218

Human Genetics   Research Article
Identification of significant pathway cross-talk in rheumatoid arthritis by the Monte Carlo cross-validation method

Authors: W. Song, Y.M. Zhang, T. Ma, J. Wang and K.Z. Wang

We attempted to identify significant pathway cross-talk in rheumatoid arthritis (RA) by the Monte Carlo cross-validation (MCCV) method. We therefore obtained and preprocessed the gene expression profile of RA. MCCV involves identifying differentially expressed genes (DEGs), identifying differential pathways (DPs), calculating .. Read More»

Genet. Mol. Res. 16(2): gmr16029142

DOI: 10.4238/gmr16029142

Human Genetics   Research Article
Genetic diversity of yacon accessions using ISSR markers

Authors: R.M. Lorenzoni, F. Menine, E. Marques J�ºnior, F.L. Oliveira and T.C.B. Soares

Yacon cultivation has been intensified and the investigations of this crop have increased at the scientific, agricultural, and social levels because the roots of yacon show beneficial properties for human health, such as reducing cholesterol and glucose blood levels. Since the investigations involving yacon are very recent, th.. Read More»

Genet. Mol. Res. 16(2): gmr16029576

DOI: 10.4238/gmr16029576

Human Genetics   Research Article
Selection of morphoagronomic descriptors for the characterization of accessions of cassava of the Eastern Brazilian Amazon

Authors: R.S. Silva, E.F. Moura, J.T. Farias-Neto, C.A.S. Ledo and J.E. Sampaio

The aim of this study was to select morphoagronomic descriptors to characterize cassava accessions representative of Eastern Brazilian Amazonia. It was characterized 262 accessions using 21 qualitative descriptors. The multiple-correspondence analysis (MCA) technique was applied using the criteria: contribution of the descript.. Read More»

Genet. Mol. Res. 16(2): gmr16029595

DOI: 10.4238/gmr16029595

Plant Genetics   Research Article
Canonical correlations between agronomic traits and seed physiological quality in segregating soybean populations

Authors: E.M. Pereira, F.M. Silva, B.H.P. Val, A. Pizolato Neto, A.O. Mauro,C.C. Martins and S.H. Un�ªda-Trevisoli

The objective of this study was to evaluate the relationship between agronomic traits and physiological traits of seeds in segregating soybean populations by canonical correlation analysis. Seven populations and two commercial cultivars in three generations were used: F3 plants and F4 seeds; F4 plants and F5 seeds, and F4 seed.. Read More»

Genet. Mol. Res. 16(2): gmr16029547

DOI: 10.4238/gmr16029547

Human Genetics   Research Article
Biotools: an R function to predict spatial gene diversity via an individual-based approach

Authors: A.R. da Silva, G. Malafaia and I.P.P. Menezes

The gene diversity or expected heterozygosity (HE) is based on the allele frequency and is often used as a measure of genetic variability of populations. Knowing the pattern of spatial distribution of HE can be useful for determining strategies of conservation and sampling of collections of individuals. In addition, it can all.. Read More»

Genet. Mol. Res. 16(2): gmr16029655

DOI: 10.4238/gmr16029655