Table of Contents | Genet. Mol. Res.2016(1)
Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance
Authors: M. Zhang and S.C. Luo
The aim of this study is to analyze gene expression data to identify key genes and pathways associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer (EOC) and to improve clinical treatment strategies. The gene expression data set was downloaded from Gene Expression Omnibus and included 12 chemotherapy-resistant EOC samples an.. Read More»
Genet. Mol. Res. 15(1): gmr.15017496
DOI: 10.4238/gmr.15017496
Computational prediction and experimental validation of a novel miRNA in Suaeda maritima, a halophyte
Authors: S.A. Gharat and B.P. Shaw
The lack of available transcriptome data for plants of no economic or agronomic importance limits the identification of miRNAs in many species. Considering the possible similarity of the transcriptome between related species, the present study used expressed sequence tags (ESTs) of Suaeda salsa and Suaeda glauca to identify conserved miRNAs, which were va.. Read More»
Genet. Mol. Res. 15(1): gmr.15017527
DOI: 10.4238/gmr.15017527
Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis
Authors: L.-D. Liu, X.-Y. Wu, B.-D. Tao, N. Wang and J. Zhang
This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung i.. Read More»
Genet. Mol. Res. 15(1): gmr.15016050
DOI: 10.4238/gmr.15016050
Isolation and characterization of the Chrysanthemum nitrate transporter CmNRT1
Authors: C.S. Gu, X.X. Zhang, S.M. Chen, T. Li, Y. Chen, J.F. Jiang and F.D. Chen
In this study, the nitrate transporter gene CmNRT1 was isolated from the chrysanthemum variety ‘Nannongxuefeng’. The full-length cDNA contains an open reading frame of 1761 bp encoding 587 residues. Using qRT-PCR, we found that CmNRT1 was induced by 10 mM NO3- in roots and shoots. Two Arabidopsis thaliana transgenic plants expressing CmNRT1 we.. Read More»
Genet. Mol. Res. 15(1): gmr.15017148
DOI: 10.4238/gmr.15017148
Construction of polycythemia vera protein interaction network and prediction of related biological functions
Authors: L.-J. Liu1, X.-J. Cao2, C. Zhou1, Y. Sun3, Q.-L. Lv3, F.-B. Feng1, Y.-Y. Zhang4 and C.-G. Sun1
Here, polycythemia vera (PV)-related genes were screened by the Online Mendelian Inheritance in Man (OMIM), and literature pertaining to the identified genes was extracted and a protein-protein interaction network was constructed using various Cytoscape plugins. Various molecular complexes were detected using the Clustervize plugin and a gene ontology-enr.. Read More»
Genet. Mol. Res. 15(1): gmr.15017169
DOI: 10.4238/gmr.15017169
Proteomic changes in maize as a response to heavy metal (lead) stress revealed by iTRAQ quantitative proteomics
Authors: G.K. Li1,3*, J. Gao4*, H. Peng1,2, Y.O. Shen1, H.P. Ding1, Z.M. Zhang1, G.T. Pan1 and H.J. Lin1
Lead (Pb), a heavy metal, has become a crucial pollutant in soil and water, causing not only permanent and irreversible health problems, but also substantial reduction in crop yields. In this study, we conducted proteome analysis of the roots of the non-hyperaccumulator inbred maize line 9782 at four developmental stages (0, 12, 24, and 48 h) under Pb pol.. Read More»
Genet. Mol. Res. 15(1): gmr.15017254
DOI: 10.4238/gmr.15017254
Development of polymorphic SSR markers in the razor clam (Sinonovacula constricta) and cross-species amplification
Authors: Y.H. Dong1, H.H. Yao1, C.S. Sun2, D.M. Lv1, M.Q. Li1 and Z.H. Lin1
Next-generation sequencing provides large-scale sequencing data with relative ease and at a reasonable cost, making it possible to identify a large amount of SSR markers in a timely and cost-effective manner. On the basis of the transcriptome database of Sinonovacula constricta obtained by Illumina/Solexa pyrosequencing, 60 polymorphic SSR markers were de.. Read More»
Genet. Mol. Res. 15(1): gmr.15017285
DOI: 10.4238/gmr.15017285
Correlation between chromosome 1p/19q status and VEGF mRNA expression in gliomas
Authors: B. Yang1*, X.Q. Hao2*, X.W. Zeng3, T.L. Ji3, S. Pan3 and Y.G. Feng1
The chromosome 1p/19q deletion has been reported as a good prognosis marker for gliomas. However, the detection of 1p/19q status alone in glioma patients is not sufficient. The identification of a combination of molecular factors could effectively enhance the prediction accuracy. Thus far, the potential correlation between the 1p/19q status and vascular e.. Read More»
Genet. Mol. Res. 15(1): gmr.15017322
DOI: 10.4238/gmr.15017322