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L. Yang

Publications of : L. Yang
Human Genetics   Research Article

Clinical significance of fascin-1 and laminin-5 in non-small cell lung cancer

Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC) were analyzed in this study. The expre.. Read More»

Genet. Mol. Res. 16(2): gmr16029617

DOI: 10.4238/gmr16029617

Animal Genetics   Research Article

Molecular cloning and expression analysis of TRAF3 in chicken

    H.L. Yang, Z.Q. Feng, S.Q. Zeng, S.M. Li, Q. Zhu and Y.P. Liu

Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a crucial regulator that suppresses c-Jun N-terminal kinase and non-canonical nuclear factor-kB signaling, but facilitates type I interferon production. To determine TRAF3 function in innate immune responses among birds, particularly chicken, we cloned and characterized the chicken TRAF3 gene (chTRAF3) and detected its tissue express.. Read More»

Genet. Mol. Res. 14(2): 2015.April.30.14

DOI: 10.4238/2015.April.30.14

Human Genetics   Research Article

Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China

    L. Yang, G.L. Shi, C.X. Song and S.F. Xu

Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that has a dose-dependent anti-tumoral effect. Polymorphism in the MCP-1 distal regulatory region (-2518A/G) can affect the level of MCP-1 expression. We examined the polymorphisms of 112 unrelated patients with non-small-cell lung cancer (NSCLC) and 82 unrelated healthy controls of Han nationality.. Read More»

Genet. Mol. Res. 9(2): vol9-2gmr740

DOI: 10.4238/vol9-2gmr740

Human Genetics   Research Article

Association of the CYP1A1 MspI and TNF�?±-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia

    L. Yang, F. Li2*, M. Yan and X. Su

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by persistent airflow limitation. Smoking, occupational exposures, air pollution, and genetics are all risk factors. In the present study, we detected the cytochrome P4501A1 gene (CYP1A1) MspI polymorphism and the tumor necrosis factor alpha (TNFα)-308 single nucleotide po.. Read More»

Genet. Mol. Res. 13(2): 2014.April.25.6

DOI: 10.4238/2014.April.25.6

Medical Genetics   Research Article

A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood

    R.H. Wu, P. Wang, L. Yang, Y. Li, Y. Liu and M. Liu

Myostatin is a secreted negative regulator of muscle mass, and follistatin antagonizes the function of several members of the TGF-b family, including myostatin. Previously, myostatin expression was found to be closely associated with atrophy of the gastrocnemius muscle, showing a linear correlation, after sciatic nerve injury. In this study, we investigated the poss.. Read More»

Genet. Mol. Res. 10(4): 2011.October.21.7

DOI: 10.4238/2011.October.21.7

Human Genetics   Research Article

A novel method for identifying SNP disease association based on maximal information coefficient

    H.M. Liu, N. Rao, D. Yang, L. Yang, Y. Li and F. Ou

To improve single-nucleotide polymorphism (SNP) association studies, we developed a method referred to as maximal information coefficient (MIC)-based SNP searching (MICSNPs) by employing a novel statistical approach known as the MIC to identify SNP disease associations. MIC values varied with minor allele frequencies of SNPs and the odds ratios for disease. We used a Monte Carlo-based permutati.. Read More»

Genet. Mol. Res. 13(4): 2014.December.19.7

DOI: 10.4238/2014.December.19.7

Human Genetics   Research Article

Spectrum and features of congenital heart disease in Xi��?an, China as detected using fetal echocardiography..

    Y.J. Wei1, B.M. Liu1, Y.H. Zhou1, X.H. Jia1, S.G. Mu2, X.R. Gao2, M.L. Yang2 and Y. Zhang2

This study aimed to investigate the spectrum and features of congenital heart disease (CHD) in Xi’an, China using fetal echocardiography. All pregnant women referred for fetal echocardiography underwent a systematic fetal echocardiographic examination. Each case of complex defects was diagnosed according to the predominant pathophysiology, and the overall frequency of each defect was reco.. Read More»

Genet. Mol. Res. 13(4):

Human Genetics   Research Article

Screening and identification of peritoneal metastasis-related genes of gastric adenocarcinoma using a cDNA microarray

    F.H. Bai, N.J. Wang, J. Wang, L. Yang, F.M. Zhang, F. Yin, J. Liang, K.C. Wu and D.M. Fan

With the aim of identifying peritoneal metastasis-related genes in gastric cancer, we performed a broad analysis of differential gene expression between the parental cell line GC9811 and its highly metastatic peritoneal counterpart, cell line GC9811-P. Two fluorescent cDNA probes, labeled with Cy3 and Cy5 dyes, were prepared from GC9811 and GC9811-P mRNA samples by .. Read More»

Genet. Mol. Res. 11(2): 2012.June.25.1

DOI: 10.4238/2012.June.25.1

Animal Genetics   Research Article

Promoter methylation and histone modifications affect the expression of the exogenous DsRed gene in transgenic goats

    M.T. Nuo, J.L. Yuan, W.L. Yang, X.Y. Gao, N. He, H. Liang, M. Cang and D.J. Liu

Transgene silencing, which is common in transgenic plants and animals, limits the generation and application of genetically modified organisms, and is associated with the exogenous gene copy number, the methylation status of its promoters, and histone modification abnormalities. Here, we analyzed the expression of the exogenous gene DsRed and the methylation status .. Read More»

Genet. Mol. Res. 15(3): gmr.15038560

DOI: 10.4238/gmr.15038560

Human Genetics   Research Article

Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer��?s disease in the Chinese population: a meta-analysis of case-control studies

    L. Yang, H.-H. Zhou, Y.-F. Ye, X.-W. Fan, Y.-J. Wang and Y. Meng

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to.. Read More»

Genet. Mol. Res. 14(1): 2015.February.6.5

DOI: 10.4238/2015.February.6.5