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Exome Sequencing Studies for Kids with Non-Familial Food Allergy

Author(s): Neda M Bogari, Amr A Amin, Husni H Rayes, Ahmed Abdelmotelb, Faisal A. Al-Allaf, Anas Dannoun, Mamdouh S Alhazmi, Saed A Basardah, Mohiuddin M Taher, Udaya Raja GK, Ashwag Aljohani, Soud Abdulraof A Khogeer, Mohamed Mahmoud Nour Eldein, Mohammad Adil, Mustafa Bogari, Imran Ali Khan, Khalid Khalaf Alharbi and Ahmed Fawzy

Introduction: Food allergies (FA) have been increasing dramatically over the past 25 years and the peanut allergy has been noticed more likely for a half-decade as well. The prevalence of FA in children was found to be 10%, which is high compared with adults. Limited periodic reports are available of numerous food allergic reactions in children. Complete exome sequencing in this context had an opportunity to investigate Saudi children diagnosed with FA. However, the genetic mechanisms and their factors underlying FA are largely not recognized. Three non-familial cases were arbitrarily selected along with three matching control children.

Results: A total of 26 mutations were documented from the six samples; 20 mutations were confirmed through FA cases and 6 from control children. There are four mutations, namely rs35364374, rs2293404, rs9657362 and rs757387978, which had not been associated with FA in any prior study with children. This mutation was appearing in both the cases and controls. However, chr5: 109973901-TMEM322 gene and chr19: 39008235-RYR1 gene appeared as novel mutations only in the control children. We could not find this mutation in any FA cases. Our study revealed four mutations which had not previously been connected with food allergy within the database and the rs35364374 and rs9657362 mutations were documented within the database with different diseases.

Conclusion: However, in the control children a couple of novel mutations were identified which have not been reported anywhere else. This study recommends screening all the six mutations in food allergy cases and their relevant controls to confirm the prevalence in the Saudi population. Future studies are recommended to study the four variants in detail.

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