Microbial Genetics
Association analysis of yield and fiber quality traits in Gossypium barbadense with SSRs and SRAPs
Authors: X.Q. Wang, Y. Yu, W. Li, H.L. Guo, Z.X. Lin and X.L. Zhang
Cotton is an important cash crop. Mining for quantitative trait loci related to yield and fiber quality traits using association analysis has many advantages for cotton research. In this study, 170 simple sequence repeats (SSRs) and 258 sequence-related amplified polymorphisms (SRAPs) were used to analyze the association of 3 yield component traits and 5 .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.4.1
- DOI:
- 10.4238/2013.September.4.1
Molecular characterization of Aspergillus flavus and aflatoxin contamination of wheat grains from Saudi Arabia
Authors: A.S. Al-Wadai, M.R. Al-Othman, M.A. Mahmoud and A.R.M. Abd El-Aziz
Twelve species belonging to six fungal genera were found to be associated with wheat (Triticum aestivum L.) grain samples collected from three main regions in Saudi Arabia. The most common genera (average frequency) were Aspergillus (14.3%), Fusarium (29.1%), Penicillium (9.3%), and Alternaria (8.2%). Nineteen isolates of Aspergillus flavus were screened .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.10
- DOI:
- 10.4238/2013.September.3.10
Molecular cloning and functional analysis of MRLC2 in Tianfu, Boer, and Chengdu Ma goats
Authors: H.G. Xu, G.Y. Xu, L. Wan and J. Ma
To determine the molecular basis of heterosis in goats, fluorescence quantitative polymerase chain reaction (PCR) was performed to investigate myosin-regulatory light chain 2 (MRLC2) gene expression in the longissimus dorsi muscle tissues of the Tianfu goat and its parents, the Boer and Chengdu Ma goats. The goat MRLC2 gene was differentially expressed in.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.15.7
- DOI:
- 10.4238/2013.March.15.7
Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever
Authors: D. Dogruer, E. Tug, C. Bes and M. Soy
The P-gp/MDR1 multidrug transporter mediates detoxification of numerous drugs, including colchicine, and CYP3A4 is key to the biotransformation of colchicine. We investigated the effects of CYP3A4 and P-gp/MDR1 polymorphisms on bioavailability of colchicine in patients with Familial Mediterranean fever (FMF). Forty-eight Turkish patients with FMF treated .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.24.2
- DOI:
- 10.4238/2013.January.24.2
Molecular analysis of the SMN gene mutations in spinal muscular atrophy patients in China
Authors: W.L. Liu, F. Li, Z.X. He, R. Ai and H.W. Ma
Spinal muscular atrophy (SMA) is one of the most common autosomal recessive diseases. Survival motor neuron1 (SMN1) is the SMA disease-determining gene. We examined the molecular basis of SMA in 113 Chinese SMA patients. Homozygous exon 7 and 8 deletions in SMN1 were detected by PCR-RFLP. Heterozygous deletion of SMN1 was analyzed based on variation of th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.4
- DOI:
- 10.4238/2013.September.13.4
Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells
Authors: T.J. Xing, H.T. Xu, W.Q. Yu and D.F. Jiang
The regulation mechanism and significance of microRNA-122 (miRNA-122) expression are unclear. The aim of this study was to investigate the effects of DNA methylation on liver-specific miRNA-122 expression, cell proliferation, and apoptosis in hepatocellular carcinoma. Methylation of the miRNA-122 promoter region was detected through methylation sequencing.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.3
- DOI:
- 10.4238/2013.September.13.3
Mutagenicity, genotoxicity, and scavenging activities of extracts from the soft coral Chromonephthea braziliensis: a possibility of new bioactive compounds
Authors: R.M. Carpes, B.G. Fleury, B.G. Lages, A.C. Pinto, C.A.F. Aiub and I. Felzenszwalb
Coral reefs are diverse ecosystems that have a high density of biodiversity leading to intense competition among species. These species may produce unknown substances, many with pharmacological value. Chromonephthea braziliensis is an invasive soft coral from the Indo-Pacific Ocean that is possibly transported by oil platforms and whose presence can be a .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.2
- DOI:
- 10.4238/2013.September.13.2
Characterization and molecular mapping of a dwarf mutant in wheat
Authors: X.J. Jin, D.F. Sun, H.Y. Li, Y. Yang and G.L. Sun
A spontaneous dwarf mutant of wheat was found in an F5 generation line derived from a cross between Huamai No. 9 and Een No. 1 in 1998; it was named Huaai 01. We characterized the genetic pattern of Huaai 01 and mapped the gene controlling the dwarf trait. This dwarf mutant was found insensitive to exogenous gibberellic acid treatment, based on the length.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.12.2
- DOI:
- 10.4238/2013.September.12.2
Mitochondrial and nuclear genes as the cause of complex I deficiency
Authors: A.R. Rezaee, A. Azadi, M. Houshmand, F. Mahmoodi, Z. Purpak, S. Safaei, P. Karimi, M. Ghabaee and M.A. Sahraian
Multiple sclerosis (MS) is an immunological inflammatory disease of the central nervous system. The pathogenesis of MS is incompletely understood, but various studies have suggested that mitochondrial dysfunction is associated with the disease. Mitochondria are among the main cellular sources of reactive oxygen and nitrogen species, and they play a pivota.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.12.1
- DOI:
- 10.4238/2013.September.12.1
Significant association of APOA5 and APOC3 gene polymorphisms with meat quality traits in Kele pigs
Authors: Y.T. Hui, Y.Q. Yang, R.Y. Liu, Y.Y. Zhang, C.J. Xiang, Z.Z. Liu, Y.H. Ding, Y.L. Zhang and B.R. Wang
Apolipoprotein A5 (APOA5) and C3 (APOC3) genes are involved in the PPAR lipid metabolism pathway and thus associated with elevated triglyceride levels. However, whether APOA5 and APOC3 genetic polymorphisms affect intramuscular fat deposition and other meat quality traits remains unknown in pigs. One hundred and seventy-one Kele pigs were sampled to inves.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.8
- DOI:
- 10.4238/2013.September.13.8