Microbial Genetics
Lack of association between the interleukin 6 gene -174G>C polymorphism and colorectal cancer: evidence from a meta-analysis
Authors: J.J. Hu, Z.T. Wang and J. Zhong
Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studie.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.2
- DOI:
- 10.4238/2013.July.8.2
Tumor necrosis factor-�± and -�² genetic polymorphisms as a risk factor in Saudi patients with vitiligo
Authors: F. Al-Harthi, A. Zouman, M. Arfin, M. Tariq and A. Al-Asmari
Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic proinflammatory cytokine, has been shown to play a critical ro.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.1
- DOI:
- 10.4238/2013.July.8.1
Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population
Authors: I.B. Han, A.E. Ropper, Y.D. Teng, D.A. Shin, Y.J. Jeon, H.M. Park, D.E. Shin, Y.S. Park, K.N. Kim and N.-K. Kim
Disturbances in blood flow to intervertebral discs (IVD) play an important role in IVD degeneration. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) are extremely important angiogenic factors for vasodilation and neovascularization. We investigated the relationship between single nucleotide polymorphisms (SNPs) of th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.10
- DOI:
- 10.4238/2013.July.8.10
Characterization and description of a multiple sex chromosome system in Potamotrygon motoro (Chondrichthyes, Myliobatiformes) from the Paran�¡ River, Argentina
Authors: D.R. Aichino, M.C. Pastori, H.A. Roncati, M.A. Ledesma, A.C. Swar�§a and A.S. Fenocchio
The Potamotrygonidae family represents the only freshwater group of specialized elasmobranchs and is composed of 4 genera: Plesiotrygon, Paratrygon, Potamotrygon, and Heliotrygon. Individuals of Potamotrygon motoro were collected from the Paraná River at Ituzaingó (Province of Corrientes) in Argentina. Mitotic preparations were obtained usin.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.16.3
- DOI:
- 10.4238/2013.January.16.3
RNA interference-mediated silencing of the starch branching enzyme gene improves amylose content in rice
Authors: H.Y. Jiang, J. Zhang, J.M. Wang, M. Xia, S.W. Zhu and B.J. Cheng
Amylose and amylopectin are the 2 major components of plant storage starch. The rice starch branching enzyme (RBE) plays an important role in the starch components of rice. In the present study, we selected a specific 195-bp segment from the RBE3 gene to construct hairpin DNA, which was driven by an endosperm-specific high molecular weight glutenin promot.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.19
- DOI:
- 10.4238/2013.January.4.19
Mutations in the ADAR1 gene in Chinese families with dyschromatosis symmetrica hereditaria
Authors: G.L. Zhang, H.J. Shi, M.H. Shao, M. Li, H.J. Mu, Y. Gu, X.F. Du and P. Xie
We investigated 2 Chinese families with dyschromatosis symmetrica hereditaria (DSH) and search for mutations in the adenosine deaminase acting on RNA1 (ADAR1) gene in these 2 pedigrees. We performed a mutation analysis of the ADAR1 gene in 2 Chinese families with DSH and reviewed all articles published regarding ADAR1 mutations reported since 2003 by usin.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.18
- DOI:
- 10.4238/2013.January.4.18
The GSTP1 A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia: results from an updated meta-analysis
Authors: G.Z. Huang, W. Shan, L. Zeng and L.G. Huang
Studies investigating the association between the glutathione S-transferase P1 (GSTP1) A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia (ALL) report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, China N.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.3
- DOI:
- 10.4238/2013.July.24.3
Molecular cytogenetics of nucleolar organizer regions in Phyllomedusa and Phasmahyla species (Hylidae, Phyllomedusinae): a cytotaxonomic contribution
Authors: A. Barth, V.A. Souza, M. Sol�© and M.A. Costa
Chromosome numbers, morphology, and nucleolus organizer region (NOR) locations are useful cytological characters for taxonomic and evolutionary studies. In this study, we provide the first cytogenetic analysis of Phyllomedusa bahiana and Phasmahyla spectabilis, and report new cytogenetic data on variation in NOR numbers and positions in Phyllomedusa rohde.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.15.3
- DOI:
- 10.4238/2013.July.15.3
Specific and straightforward molecular investigation of �²-thalassemia mutations in the Malaysian Malays and Chinese using direct TaqMan genotyping assays
Authors: S.L. Kho, K.H. Chua, E. George and J.A.M.A. Tan
Beta-thalassemia is a life-threatening inherited blood disorder. Rapid characterization of β-globin gene mutations is necessary because of the high frequency of Malaysian β-thalassemia carriers. A combination real-time polymerase chain reaction genotyping assay using TaqMan probes was developed to confirm β-globin gene mutations. In this st.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.4
- DOI:
- 10.4238/2013.February.28.4
Molecular cloning and characterization of the glyceraldehyde-3-phosphate dehydrogenase gene from Penicillium expansum PE-12
Authors: T. Zhang, Z. Qi, Q.S. Yu and K.X. Tang
Penicillium expansum produces large amounts of lipase, which is widely used in laundry detergent and leather industry. We isolated the glyceraldehyde-3-phosphate dehydrogenase gene (PeGPD) from P. expansum PE-12 through reverse transcriptase PCR and 5êÃ?Â?Ã?Â?-3êÃ?Â?Ã?Â?-rapid amplification of cDNA ends (RACE-PCR). The gene is 1266 bp long, in.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.6.2
- DOI:
- 10.4238/2013.February.6.2