Human Genetics
Genotoxicity testing of Ambelania occidentalis (Apocynaceae) leaf extract in vivo
Authors: L.S. Castro, F.F. Perazzo and E.L. Maistro
Ambelania occidentalis is routinely used in folk medicine for treating gastrointestinal disorders, even though there have been no safety trials. We evaluated the genotoxic potential of hydro-alcoholic extracts of this plant in mice; induced DNA damage was assessed in peripheral blood leukocytes and micronucleus induction was a.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr588
- DOI:
- 10.4238/vol8-2gmr588
A patient with ascending aortic dilatation, similar to phenotypes of connective tissue disorders
Authors: S.T. Onrat, M. Emmiler, Y. S�±vac�±, Z. S�¶ylemez,A. ��zg�¶z, N. Imirzal�±o��lu
We report on the clinical and molecular findings of a patient who presented alopecia, epicanthus, micrognathia, retrognathia, high arched palate, hypertelorism, Chiari type I malformation, mixed-type hearing loss but with normal heartbeat Q-T interval, malformed earlobes, down-slanted palpebral fissures, downturned corners of .. Read More»
- Genet. Mol. Res. 8(2):
Identification of Turkish and standard apple rootstocks by morphological and molecular markers
Authors: A. Koc, M. Akbulut, E. Orhan, Z. Celik, S. Bilgener and S. Ercisli
Two local (Vezir-1 and Vezir-2) and two standard (M9 and MM106) clonal apple rootstocks were compared using both morphological and molecular markers. International Union for the Protection of New Varieties of Plants criteria were used for morphological evaluation, which did not clearly separate these rootstocks. We tested 47 r.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr600
- DOI:
- 10.4238/vol8-2gmr600
Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus
Authors: D.N. Fang, X.D. He, X.H. Li, H. Jia, P.Y. Li, Q. Lu, Z. Quan and Q.L. Wang
We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.3.1
- DOI:
- 10.4238/2014.January.3.1
In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells
Authors: S.J. Peng, J. Li, Y. Zhou, M. Tuo, X.X. Qin, Q. Yu, H. Cheng and Y.M. Li
Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029434
- DOI:
- 10.4238/gmr16029434
Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature
Authors: W. Wang, X.P. Luo, L.X. Cai, Z.R. Cui, X.Y. Luo and R.K. Luo
Polymorphisms in the vitamin D receptor (VDR) gene are associated with idiopathic short stature (ISS) in several countries. This study aimed to identify a possible correlation between polymorphisms in the VDR promoter in Chinese children with ISS and the efficacy of the recombinant human growth hormone (rhGH) treatment. Pre-pubertal children with ISS and .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.12
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.12
Molecular characterization of olive cultivars using amplified fragment length polymorphism markers
Authors: S. Ercisli, E. Barut and A. Ipek
We sampled six olive cultivars (Tavli Sati, Sati, Gorvela, Sacakli Otur, Butko, and Otur) from Coruh Valley, located in the northeast part of Turkey, and characterized them using amplified fragment length polymorphism (AFLP) markers. Some morphological and biochemical characteristics are also determined. Six AFLP primer combin.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr576
- DOI:
- 10.4238/vol8-2gmr576
Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population
Authors: H.M. Wang, N.F. Li, J. Hong, L. Zhou and J.H. Chang
Genetic variation is thought to contribute to etiology of metabolic syndrome (MS). Neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L) is a candidate gene for MS. This study investigated the relationship between variations of NEDD4L and MS in the Kazakh, which is an ideal population to study the .. Read More»
- Genet. Mol. Res. 12(1):
- 2014.January.8.1
- DOI:
- 10.4238/2014.January.8.1
Expression profiles of DNA repair-related genes in rat target organs under subchronic cadmium exposure
Authors: Y.X. Lei, Q. Lu, C. Shao, C.C. He, Z.N. Lei and Y.Y. Lian
We aimed to evaluate the toxicity of long-term exposure to different cadmium (Cd) doses in rats and expression profiles of DNA repair-related genes. The model rats were exposed to different concentrations of CdCl2 for 3 months, and 5 DNA repair-related genes - hMSH2, MLH1, XRCC1, hOGG1, ERCC1 - were cloned in different tissues, including the liver, kidney.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.5
- DOI:
- 10.4238/2015.January.26.5
DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity
Authors: M. Santos, L.L. Maia, C.V.M. Silva, G.T. Peterle, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
Death-associated protein 1 (DAP1) is a member of the DAP family. Its expression is associated with cell growth and normal death of the neoplastic cells, regulated by the mammalian target of the rapamycin protein. Activated DAP1 negatively regulates autophagy, which has been associated with the development and progression of several diseases, such as cance.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.13
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.13