Human Genetics
RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos
Authors: F. He, C.-T. Wang and L.-T. Gou
RBM22 is a newly discovered RNA-binding motif protein, belonging to the SLT11 family; it has been reported to be involved in pre-splicesome assembly and to interact with the Ca2+-signaling protein ALG-2. However, previous studies have not demonstrated whether its expression is essential for early embryogenesis in vertebrates. .. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr683
- DOI:
- 10.4238/vol8-4gmr683
A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections
Authors: C. Lin,R. Ye, Y.L. Xia
Novel coronavirus (nCoV) belongs to the Coronaviridae family, which includes the virus that causes SARS, or severe acute respiratory syndrome. However, infection source, transmission route, and host of nCoV have not yet been thoroughly characterized. In some cases, nCoV presented a limited person-to-person transmission. Theref.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.15
- DOI:
- 10.4238/2015.December.1.15
XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia
Authors: J.P. Meza-Espinoza, V. Peralta-Leal, M. Gutierrez-Angulo,N. Macias-Gomez, M.L. Ayala-Madrigal, P. Barros-Nu�±ez,J. Duran-Gonzalez and E. Leal-Ugarte
We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico. All of them were genotyped for these polymorphisms, using polymerase chain rea.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr687
- DOI:
- 10.4238/vol8-4gmr687
Influence of suppression of CapG gene expression by siRNA on the growth and metastasis of human prostate cancer cells
Authors: B.K. Li, K. Guo, C.Y. Li, H.L. Li, P.P. Zhao,K. Chen,C.X. Liu
This study investigated CapG gene expression in prostate cancer cell lines; in addition, we explored the effects of CapG suppression on DU145 cell growth, and the underlying mechanism with which CapG affects DU145 cell growth and invasiveness. The expression of CapG and 18 related genes in DU145 cells was analyzed by flow cyto.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.28
- DOI:
- 10.4238/2015.December.1.28
Cardiac damage and dysfunction in diabetic cardiomyopathy are ameliorated by Grx1
Authors: X. Qi, A. Xu, Y. Gao, Y. Shi, X. Sun, J. Xu, J. Liu, Q. Lan, L. Chang, C. Zhang and H. Yu
Glutaredoxin 1 (Grx1) has been found to be an important endogenous antioxidant enzyme closely related to the pathogenesis of diabetes and cardiovascular diseases caused by oxidative stress. In this study, the functional changes of the Grx1 redox system in blood of hyperglycemic patients were examined. Furthermore, using a rat model of streptozotocin (STZ).. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039000
- DOI:
- 10.4238/gmr.15039000
Association of polymorphism in ICAM-1 (K469E) and cytology parameters in patients� initial blood test with acute ischemic stroke
Authors: D. Wang, F.H. Zhang,Y.T. Zhao, X.G. Xiao,S. Liu, H.B. Shi, A.L. Lin, Y.J. Wang, Q. Han, Q.M. Sun
Acute ischemic stroke (AIS) has become a serious health problem in many countries because of its poor outcome and worsening epidemic trend. Early identification of genetic risk factors and physiological indicators for stroke occurrence may help to reduce the incidence of stroke. Therefore, we conducted a case-control study inc.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.2
- DOI:
- 10.4238/2015.December.1.2
Molecular characterization, tissue expression, and polymorphism analysis of liver-type fatty acid binding protein in Landes geese
Authors: Z. Song, D. Shao, X.X. Sun, J.W. Niu and D.Q. Gong
Liver weight is an important economic trait in the fatty goose liver industry. Liver-type fatty acid binding protein (L-FABP) is involved in the formation and metabolism of fatty acids. Thus, we hypothesized that sequence polymorphisms in L-FABP were associated with fatty liver weight in goose. We first isolated, sequenced, and characterized the goose L-F.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.12
- DOI:
- 10.4238/2015.January.23.12
JNK pathway and relative transcriptional factor were involved in ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
Authors: X. Liu, Y. Sun, L. Yue, S. Li, X. Qi, H. Zhao, Y. Yang, C. Zhang and H. Yu
Ginsenoside Rh2 has been shown to have an anti-tumor effect on a wide range of cancers. A previous study has shown that ginsenoside Rh2 can inhibit the proliferation of the human lung adenocarcinoma A549 cell line in a dose-dependent manner byactivating caspase-8/3 activity to promote apoptosis. However, the association of the JNK signaling pathways and t.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039003
- DOI:
- 10.4238/gmr.15039003
Comparison of DNA extraction methods for polymerase chain reaction amplification of guanaco (Lama guanicoe) fecal DNA samples
Authors: M.I. Espinosa, A. Bertin, F.A. Squeo, A. Cort�©s and N. Gouin
Feces-based population genetic studies have become increasingly popular. However, polymerase chain reaction (PCR) amplification rates from fecal material vary depending on the species, populations, loci, and extraction protocols. Here, we assessed the PCR amplification success of three microsatellite markers and a segment of the mitochondrial control regi.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.13
- DOI:
- 10.4238/2015.January.23.13
In vitro inhibition of invasion and metastasis in colon cancer cells by TanIIA
Authors: R.W. Zhang, Z.G. Liu, Y. Xie, L.X. Wang, M.C. Li and X. Sun
The purpose of this study was to investigate the effect of the traditional Chinese medicine TanIIA on the viability, invasion, and metastasis of SW480 cells. SW480 cells were treated with TanIIA for 24 h, and MTT assays were performed to determine the effect of TanIIA on cell viability. Transwell transmembrane experiments were applied to test the effect o.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039008
- DOI:
- 10.4238/gmr.15039008