Human Genetics
Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer
Authors: S.Q. Zhang, G.Q. Zhang and L. Zhang
Prostate cancer is a common malignant tumor in males with an unclear pathogenic mechanism. As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. The E-Cadherin gene is involved in cell meta.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028046
- DOI:
- 10.4238/gmr.15028046
Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population
Authors: J. Dang, L. Peng, H.J. Zhong and Z.H. Huo
The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.10
- DOI:
- 10.4238/2015.August.28.10
Influence of the DCC gene on proliferation and carcinoembryonic antigen expression in the human colorectal cancer cell line SW1116
Authors: H.W. Jiang, J. Wang, H.J. Li, J.K. Peng, X.P. Gao and F. Chen
This study investigated the effects of stable transfection of the exogenous wild-type DCC gene on growth of the human colorectal carcinoma cell line SW1116 in vitro. The DCC gene was amplified from normal human colon tissue by reverse transcription-polymerase chain reaction and used to construct a recombinant expression plasmid, pcDNA3.1(+)-DCC. DCC-negat.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.12
- DOI:
- 10.4238/2015.August.28.12
Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes
Authors: T.X. Deng, C.Y. Pang, M.Q. Liu, C. Zhang and X.W. Liang
Melanocortin-4 receptor (MC4R) is associated with feed intake, growth, fatness, and carcass composition in many domestic animals. The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Eight SNPs were identified by direct polymerase .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028153
- DOI:
- 10.4238/gmr.15028153
Phylogenetic relationships of Pseudohynobius (Urodela, Hynobiidae) inferred from DNA barcoding analysis
Authors: Y.-Y. Zhao, L.-N. Su, Z.-M. Zhang and X.-Y. Wang
As a proven tool, DNA barcoding can identify species rapidly and unambiguously. In this study, we used mtDNA cyt b, COI, and 16s rRNA sequences of six species of Pseudohynobius, Protohynobius puxiongensis, Liua shihi, Ranodon sibiricus, and Pachyhynobius shangchengensis, to reconstruct the phylogenetic relationships using Baye.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028155
- DOI:
- 10.4238/gmr.15028155
Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells
Authors: H.CH. Li, Y.X. Zhang, Y. Liu and Q.SH. Wang
We investigated the effect of the IL-17 monoclonal antibody Secukinumab combined with IL-35 in the blockade of the Notch signaling pathway on the invasive capability of hepatoma cells. We examined the effects of IL-17 antibody or IL-35 treatment alone or in combination on cell invasion and migration capabilities with Transwell.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028174
- DOI:
- 10.4238/gmr.15028174
HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women
Authors: S.M. Li, H. Guo, H.J. Yang, M.Q. Lv and D.X. Zhou
Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. P.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.18
- DOI:
- 10.4238/2015.August.28.18
Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis
Authors: J. Qin and Y.H. Chen
We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes w.. Read More»
- Genet. Mol. Res. 15(2):
Effects of miR-26a on the expression of Beclin 1 in retinoblastoma cells
Authors: M. Li, X.M. Chen, D.M. Wang, L. Gan and Y. Qiao
The aim of this study was to evaluate the effects of miR-26a on Beclin 1 expression in retinoblastoma (RB) cell lines (Y79 and WERi-RB-1). RB cells were transfected with miR-26a mimic, antagomir-26a, or control mimic. The Beclin 1 mRNA and protein levels were detected by quantitative polymerase chain reaction and western blot,.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028193
- DOI:
- 10.4238/gmr.15028193
Association between TNF-�± -308G>A and -238G>A gene polymorphisms and TNF-�± serum levels in Mexican colorectal cancer patients
Authors: I.A. Guti�©rrez-Hurtado, A.M. Puebla-P�©rez, J.I. Delgado-Saucedo, L.E. Figuera, G.M. Z�º�±iga-Gonz�¡lez, K. Gomez-Mariscal,C.A. Ronquillo-Carre�³n and M.P. Gallegos-Arreola
The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CR.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028199
- DOI:
- 10.4238/gmr.15028199