Human Genetics
Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population..
Authors: A. Quintero-Ramos1, S.A. Guti�©rrez-Rubio1, A. Del Toro-Arreola1, R.A. Franco-Topete1,2, A. Oceguera-Villanueva3, L.M. Jim�©nez-P�©rez4, J.M. Castro-Cervantes5, A. Barrag�¡n-Ruiz6, J.G. V�¡zquez-Camacho7 and A. Daneri-Navarro
Breast cancer (BC) is the leading cause of cancer-related deaths among women in Mexico. Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) 8 tandem repeat in the TS 5'-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3'-untranslated region (TS 3'-UTR), increase the rate of m.. Read More»
- Genet. Mol. Res. 13(4):
In vivo mechanism study of NGAL in rat renal ischemia-reperfusion injury....
Authors: In vivo mechanism study of NGAL in rat renal ischemia-reperfusion injury...
This study aimed to determine the protective effect and mechanism of neutrophil gelatinase-associated lipocalin (NGAL) in rat kidney on ischemia/reperfusion injury (I/R). The rat I/R model was set up by cutting one kidney and clamping the contralateral renal pedicle for 45 min. Male SD rats were randomly divided into sham-operation, I/R and NGAL groups. H.. Read More»
- Genet. Mol. Res. 13(4):
Complete mitochondrial genome sequence of Marmota himalayana (Rodentia: Sciuridae) and phylogenetic analysis within Rodentia
Authors: Q.J. Chao, Y.D. Li, X.X. Geng, L. Zhang, X. Dai, X. Zhang, J. Li and H.J. Zhang
This is the first report of a complete mitochondrial genome sequence from Himalayan marmot (Marmota himalayana, class Marmota). We determined the M. himalayana mitochondrial (mt) genome sequence by using long-PCR methods and a primer-walking sequencing strategy with genus-specific primers. The complete mt genome of M. himalaya.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.3
- DOI:
- 10.4238/2014.April.14.3
Male infertility in Northeast China: molecular detection of Y chromosome microdeletions in azoospermic patients with Klinefelter�s syndrome
Authors: H.-G. Zhang, Z.-B. Zhang, R.-X. Wang, Y. Yu, X.-W. Yu, E. Fadlalla and R.-Z. Liu
The prevalence of microdeletions of azoospermia factor (AZF) among azoospermic Klinefelter’s syndrome (KFS) patients shows conflicting data. We aimed to detect this frequency in a Northeast Chinese population, and to investigate the possible association between AZF microdeletions and KFS by comparison with previous conflicting reports. Eighty men af.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.9
- DOI:
- 10.4238/2013.October.24.9
Analysis of BCR/ABL transcripts in healthy individuals
Authors: J.A. Boquett1, J.R.P. Alves2 and C.E.C. de Oliveira3
The chimeric oncogene BCR/ABL, which is the product of reciprocal translocation between chromosomes 9 and 22, is a known molecular marker of chronic myeloid leukemia (CML), and is related to the major factors involved in leukemogenesis. Some previous studies have also reported the presence of this oncogene in peripheral blood cells of healthy individuals... Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.8
- DOI:
- 10.4238/2013.October.24.8
Inbreeding effects in Solanum lycocarpum A. St.-Hil populations, an endangered species of the Brazilian Cerrado
Authors: T.M. Moura, M.V.B.M. Siqueira, G.C.X. Oliveira
The inbreeding effective population size is an estimate of inbreeding and genetic drift in populations. It is an important tool for conservation genetics because it represents the number of individuals that are effectively contributing alleles to the subsequent generations. Several studies have been published in the last decad.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.10
- DOI:
- 10.4238/2013.November.26.10
Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations
Authors: L.S. Wang, Y. Jiao, Y. Huang, X.Y. Liu, G. Gibson, B. Bennett,K.M. Hamre, D.W. Li, H.Y. Zhao, J. Gelernter, H.R. Kranzler,L.A. Farrer, L. Lu, Y.J. Wang, W.K. Gu
In prior work, congenic strains carrying the DBA/2Igb (D2) region of chromosome 2 (Chr2) for alcohol preference were bred onto a C57BL/6Ibg (B6) background and as predicted were found to reduce voluntary consumption. Subsequently, interval-specific congenic recombinant strains (ISCRS) were generated and also tested. These ISCR.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.9
- DOI:
- 10.4238/2013.November.26.9
Plasma chemerin level in metabolic syndrome
Authors: D. Wang, G.-Y. Yuan, X.-Z. Wang, J. Jia, L.-L. Di, L. Yang, X. Chen,F.-F. Qian and J.-J. Chen
To investigate the chemerin level in the Chinese Han population with metabolic syndrome and its relationship with each metabolic syndrome component [body mass index (BMI), blood pressure, blood lipids, and blood glucose], we selected 30 patients with metabolic syndrome and 30 healthy control subjects. The chemerin level was me.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.8
- DOI:
- 10.4238/2013.November.26.8
Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer
Authors: D.J. Chu, D.E. Yao, Y.F. Zhuang, Y. Hong, X.C. Zhu, Z.R. Fang, J. Yu and Z.Y. Yu
Although new chemotherapeutic drugs have been applied constantly, their efficacy for non-small cell lung cancer (NSCLC) is still not satisfactory. In recent years, epidemiological investigations have shown that lung cancer may be induced by chronic Chlamydia pneumoniae (Cpn) infection, since stable high titers of Cpn antibodie.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.14.8
- DOI:
- 10.4238/2014.April.14.8
Association of the estrogen receptor-�² gene RsaI and AluI polymorphisms with human idiopathic thin endometrium
Authors: A.W. Le, Z.H. Wang, R. Yuan, L.L. Shan, T.H. Xiao, R. Zhuo, Y. Shen
The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (cont.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.26.7
- DOI:
- 10.4238/2013.November.26.7