Human Genetics
Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population
Authors: M. Li, R.J. Li, H. Bai, P. Xiao, G.J. Liu, Y.W. Guo and J.Z. Mei
We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People’s Hospita.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027516
- DOI:
- 10.4238/gmr.15027516
Isolation of a novel lipase from a metagenomic library derived from mangrove sediment from the south Brazilian coast
Authors: G.H. Couto, A. Glogauer, H. Faoro, L.S. Chubatsu, E.M. Souza and F.O. Pedrosa
A novel gene coding for a LipA-like lipase with 283 amino acids and a molecular mass of 32 kDa was isolated and characterized from a metagenomic library prepared from mangrove sediment from the south Brazilian coast. LipA was 52% identical to a lipolytic enzyme from an uncultured bacterium and shared only low identities (≤3.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr738
- DOI:
- 10.4238/vol9-1gmr738
Sperm quality and DNA damage in men from Jilin Province, China, who are occupationally exposed to ionizing radiation
Authors: D.D. Zhou, J.L. Hao, K.M. Guo, C.W. Lu and X.D. Liu
Long-term radiation exposure affects human health. Ionizing radiation has long been known to raise the risk of cancer. In addition to high doses of radiation, low-dose ionizing radiation might increase the risk of cardiovascular disease, lens opacity, and some other non-cancerous diseases. Low- and high-dose exposures to ioniz.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018078
- DOI:
- 10.4238/gmr.15018078
Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study
Authors: E.S. AlSuhaibani, N.A. Kizilbash, S. Malik, J.I. Dasti, F. Al Beladi and N. El-Morshedi
Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017360
- DOI:
- 10.4238/gmr.15017360
Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis
Authors: G.J. Suo and Z.X. Zhao
We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bas.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.1
- DOI:
- 10.4238/2013.September.19.1
Molecular cloning, polymorphisms, and association analysis of the promoter region of the STAM2 gene in Wuchuan Black cattle
Authors: Y.-Q. Yang, Y.-T. Hui, R.-Y. Liu, R.-G. Jiao, Y. Gong, Y.-Y. Zhang and H.-Q. Xie
The STAM protein plays an important role in the cytokine-related JAK/STAT pathway. We selected the STAM2 gene as a candidate gene that could be linked to growth performance in analysis of a Chinese cattle breed (Wuchuan Black cattle). We examined genetic variants in the promoter region of the STAM2 gene and their associations with eight growth traits in 1.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.9
- DOI:
- 10.4238/2013.September.13.9
Prevalence of variants that confer risk for venous thromboembolism in an elderly population of northeastern Brazil
Authors: H. Ferreira-Fernandes, P.N. Costa, H.F. Fernandes, A.P. Ara�ºjo-Neto, F.J. Motta, R. Canalle, F.K. Yoshioka, J.F. Guerreiro, R.R. Burbano, J.A. Rey and G.R. Pinto
Venous thromboembolism (VTE) is an important cause of morbidity and mortality stemming from cardiovascular disease. It is a multifactorial disease caused by a combination of acquired risk factors, of which advanced age is the most significant, and genetic factors, including the variants FV G1691A, FII G20210A, and MTHFR C677T. We estimated the prevalence .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.Mach.11.5
- DOI:
- 10.4238/2013.Mach.11.5
Identification of miRNAs and their targets in wheat (Triticum aestivum L.) by EST analysis
Authors: J. Han, M.L. Kong, H. Xie, Q.P. Sun, Z.J. Nan, Q.Z. Zhang and J.B. Pan
MicroRNAs (miRNAs) are a newly discovered class of noncoding small RNAs that regulate gene expression by directing target mRNA cleavage or translational inhibition. A large number of miRNAs have been identified in plants. Increasing evidence has shown that miRNAs play multiple roles in plant biological processes. So far, identification of miRNAs has been .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.11
- DOI:
- 10.4238/2013.September.19.11
Genetic structure of Aedes aegypti populations determined using pairwise comparisons
Authors: T. de F. Patarro, M.M. Guirado, L.M. Ravazzi and H.E.M. de C. Bicudo
The biological characteristics of Aedes aegypti (Diptera, Culicidae), which is a vector of dengue and yellow fever, make this organism a good model for studying population structure and the events that may influence it under the effect of human activity. We assessed the genetic variability of five A. aegypti populations using RAPD-PCR technique and six pr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.9
- DOI:
- 10.4238/2013.September.19.9
Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk
Authors: R. Zhu, L.Q. Bi, H. Kong, S.L. Tilley, H. Wang and W.P. Xie
Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-convertin.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.8