Human Genetics
Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population
Authors: H. Zhao, H.W. Zhang, T. Zhang and X.M. Gu
ABSTRACT. In the present study, we aimed to investigate the association between the TNF-α -308G>A polymorphism and the risk of esophageal cancer in a Han Chinese population. The case group included 342 patients with esophageal cancer and the control group comprised 300 healthy individuals. The TNF-α -308G>A p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025866
- DOI:
- 10.4238/gmr.15025866
Lack of association of functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in the Chinese population based on a case-control study and a meta-analysis
Authors: L.J. Qin, J. Wen, Y.L. Qu and Q.Y. Huang
Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotyp.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.9
- DOI:
- 10.4238/2013.September.3.9
Effect of atmospheric fine particles on epidermal growth factor receptor mRNA expression in mouse skin tissue
Authors: X. Han, W.L. Liang, Y. Zhang, L.D. Sun and W.Y. Liang
We investigated the effect of atmospheric fine particles on epidermal growth factor receptor (Egfr) mRNA expression in mouse skin tissue and explored the effect of atmospheric fine particles on skin aging. Forty female BALB/c mice were randomly divided into four groups (each comprising 10 mice) as follows: a saline control gro.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017188
- DOI:
- 10.4238/gmr.15017188
Epidemiology, species distribution, antifungal susceptibility, and ERG11 mutations of Candida species isolated from pregnant Chinese Han women
Authors: L. Yang, M.Q. Su, Y.Y. Ma, Y.J. Xin, R.B. Han, R. Zhang, J. Wen and X.K. Hao
The widespread use of antifungal agents has led to increasing azole resistance in Candida species. A major azole-resistance mechanism involves point mutations in the ERG11 gene, which encodes cytochrome P450 lanosterol 14a-demethylase. In this study, vaginal swabs were obtained from 657 pregnant Chinese Han women and cultured .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027168
- DOI:
- 10.4238/gmr.15027168
DNA detection of Clostridium difficile infection based on real-time resistance measurement
Authors: C. Liu, D.N. Jiang, G.M. Xiang, F.K. Luo, L.L. Liu, J.C. Yu and X.Y. Pu
We used a newly developed electrochemical method, real-time resistance measurement, based on loop-mediated isothermal amplification (LAMP), with real-time resistance monitoring and derivative analysis. DNA extracted from specimens was amplified through LAMP reaction. The 2 products of LAMP, DNA and pyrophosphate, both are negative ions; they combine with .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.6
- DOI:
- 10.4238/2013.September.3.6
Association of glutathione S-transferase (GST) genetic polymorphisms with treatment outcome of cisplatin-based chemotherapy for advanced non-small cell lung cancer in a Chinese population
Authors: H.L. Xiao, Z.T. Yang, F. Han and H.X. Wei
The aim of this study was to evaluate the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the chemotherapy response and overall survival of advanced NSCLC. Two hundred and sixty-two patients with histologically confirmed advanced NSCLC (inoperable TNM stages IIIA, IIIB, and IV) wer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027320
- DOI:
- 10.4238/gmr.15027320
Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population
Authors: L.J. Liu, X.Y. Zhang, N. He K Liu, X.G. Shi, T. Feng, T.T. Geng, D.Y. Yuan, L.L. Kangand T.B. Jin
Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027381
- DOI:
- 10.4238/gmr.15027381
Association of C/T polymorphism in intron 14 of the dopamine transporter gene (rs40184) with major depression in a northeastern Thai population
Authors: N. Pattarachotanant, T. Sritharathikhun, S. Suttirat and T. Tencomnao
Several lines of evidence suggest that the dopaminergic system is involved in the pathophysiology of major depressive disorder (MDD). Since the dopamine transporter (DAT1, also known as SLC6A3), mediates the active reuptake of dopamine from the synapses and thereby plays a vital role in the regulation of dopaminergic neurotran.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr757
- DOI:
- 10.4238/vol9-1gmr757
Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
Authors: P. Coutinho, V. Sandim, J.A. Oliveira, G. Alves and A. Hatagima
The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr753
- DOI:
- 10.4238/vol9-1gmr753
Relationship between the expression of Notch1 and EZH2 and the prognosis of breast invasive ductal carcinoma
Authors: L. Zhao, Q.Y. Zhang, X. Luan, X. Huang, S. Zhao and H. Zhao
We determined whether the coexpression of Notch1 and EZH2 influences the progression and prognosis of breast invasive ductal carcinoma. Using the c2 test, a significant difference was found between high and low expression of Notch1 in terms of lymph node, hormone receptor, and p53 expression (P < 0.05). Moreover, a signific.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017464
- DOI:
- 10.4238/gmr.15017464