Human Genetics
A discrete artificial bee colony algorithm for detecting transcription factor binding sites in DNA sequences
Authors: D. Karaboga and S. Aslan
The great majority of biological sequences share significant similarity with other sequences as a result of evolutionary processes, and identifying these sequence similarities is one of the most challenging problems in bioinformatics. In this paper, we present a discrete artificial bee colony (ABC) algorithm, which is inspired.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028645
- DOI:
- 10.4238/gmr.15028645
Identification of disturbed pathways in heart failure based on Gibbs sampling and pathway enrichment analysis
Authors: P. Chen, L.H. Guo, Y.K. Guo, Z.J. Qu, Y. Gao and H. Qiu
We identified disturbed pathways in heart failure (HF) based on Gibbs sampling combined with pathway enrichment analysis. A total of 396 Markov chains (MCs) (gene count >5) were obtained. After Gibbs sampling, six differentially expressed molecular functions (DEMFs) (possibility ≥0.8) were obtained. As statistical analys.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027956
- DOI:
- 10.4238/gmr.15027956
Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon
Authors: E.B. Machado, B.B. Souza, R.C. Guimar�£es, J.S.N. Azevedo, E.C. Gon�§alves, H.F.L. Ribeiro, S.T. Rolim Filho, E. Silva Filho
Buffalo farming in Brazil is increasing, as is the challenge of identifying molecular markers that will improve productivity. Therefore, the aim of this study was to analyze single nucleotide polymorphisms of the receptor gene for the hormone melatonin in buffaloes from northern Brazil by polymerase chain reactions (PCRs) and .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027960
- DOI:
- 10.4238/gmr.15027960
Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus
Authors: J.R. Lin, H.H. Qin, Y. Wang, J. Liang and J.H. Xu
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory react.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028007
- DOI:
- 10.4238/gmr.15028007
Cytotoxic and immunomodulatory effects of Ebenus boissieri Barbey on breast cancer cells
Authors: N. Imir, E. Aydemir E. Simsek, R.S. Gokturk, E. Yesilada and K. Fiskin
We aimed to determine the cytotoxic and immunomodulatory effects of hydroalcoholic extracts of the roots and aerial parts of Ebenus boissieri (EB) on breast cancer MDA-MB231 cells and the non-cancerous human embryonic kidney cell line, 293T. Cell viability was determined by MTT assay, trypan blue exclusion, and Live/Dead Viabi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017766
- DOI:
- 10.4238/gmr.15017766
Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma
Authors: M.W. Peng, S.Q. Lu, J. Liu and C.Y. Dong
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain r.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017984
- DOI:
- 10.4238/gmr.15017984
Monitoring tissue blood oxygen saturation in the internal jugular venous area using near infrared spectroscopy
Authors: Z.S. Ruan, T. Li, R.R. Ren, Y. Zhao, K. Li, Y.F. Mao, G. Shen and L. Jiang
Central venous blood oxygen saturation (ScvO2) is an important monitoring index of fluid resuscitation. However, monitoring of ScvO2 is not continuous and invasive. Near infrared spectroscopy (NIRS) is an optical technology for the noninvasive detection of hemodynamic changes, with advantages of being real-time, continuous, lo.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.23
- DOI:
- 10.4238/2015.March.31.23
Genetic diversity in the germplasm of black pepper determined by EST-SSR markers
Authors: B.D. Wu, R. Fan, L.S. Hu, H.S. Wu and C.Y. Hao
This study aimed to assess genetic diversity in the germplasm of black pepper from around the world using SSR markers from EST. In total, 13 markers were selected and successfully amplified the target loci across the black pepper germplasm. All the EST-SSR markers showed high levels of polymorphisms with an average polymorphis.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018099
- DOI:
- 10.4238/gmr.15018099
Expression of Epstein-Barr virus antibodies EA-IgG, Rta-IgG, and VCA-IgA in nasopharyngeal carcinoma and their use in a combined diagnostic assay
Authors: Y. Li, K. Wang, S.K.Yin, H.L. Zheng and D.L. Min
Epstein-Barr virus (EBV) infection is closely associated with nasopharyngeal carcinoma, which can be monitored by the levels of Rta protein antibody IgG (Rta-IgG), early antigen antibody (EA-IgG), and viral capsid antibody (VCA-IgA). In the present study, we investigated the serum levels of Rta-IgG, EA-IgG, and VCA-IgA in naso.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017368
- DOI:
- 10.4238/gmr.15017368
Initial periodontal therapy for the treatment of gingival pregnancy tumor
Authors: Y.Q. Zhu, Y.Q. Wang, Y.C. Tang and C.Z. Li
The purpose of this study was to evaluate the clinical efficacy of initial periodontal therapy in gingival pregnancy tumors. Thirty-nine patients diagnosed with gingival tumors of pregnancy between 2007 and 2015 were enrolled in this study. The patients received initial periodontal therapy, then supportive periodontal therapie.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028119
- DOI:
- 10.4238/gmr.15028119