Human Genetics

Association of the IL-4R Q576R polymorphism and asthma in the Chinese Han population: A meta-analysis

Authors: Z.Y. Huang, B.J. Cheng, G.J. Cai and B.F. Zhang

The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated th.. Read More»

Genet. Mol. Res. 14(1):

2015.March.31.21

DOI:

10.4238/2015.March.31.21

Characterization of novel polymorphic genomic microsatellite markers of Boehmeria tricuspis (Hance) Makino

Authors: Q. Tang, J.H. Chen, G.G. Zang and M.B. Luan

In the present study, 59 polymorphic microsatellite loci of Boehmeria tricuspis (Hance) Makino were developed from the specific length amplified fragment sequencing data library of genome. The number of alleles per locus ranged from two to five, and the observed and expected heterozygosities ranged from 0.0000 to 1.0000 and fr.. Read More»

Genet. Mol. Res. 15(2):

gmr.15027882

DOI:

10.4238/gmr.15027882

Psychological characteristics of and counseling for carriers of structural chromosome abnormalities

Authors: H.L. Wang, B. Wu, K.M. Guo and R.H. Tian

Infertility as a psychological problem has gained increasing attention. Male partners among infertile couples have elevated levels of psychological distress, which could affect semen quality, result in hormonal abnormalities, and increase the occurrence of early miscarriage. Infertile women are more vulnerable to psychological.. Read More»

Genet. Mol. Res. 15(2):

gmr.15028159

DOI:

10.4238/gmr.15028159

Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer

Authors: J.H. Sun, N. Fan and Y. Zhang

In this study, we investigated the correlation between serum chemokine (C-C motif) ligand 18 (CCL-18) and the prognosis as well as clinical characteristics of breast cancer. Blood samples from 207 breast cancer patients, 126 individuals with benign breast tumors, and 93 healthy women were collected. Serum CCL-18 expression was.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038632

DOI:

10.4238/gmr.15038632

Transferability and characterization of microssatellite loci in Anacardium humile A. St. Hil. (Anacardiaceae)

Authors: T.N. Soares, L.L. Sant�Ana, L.K. de Oliveira, M.P.C. Telles and R.G. Collevatti

Microsatellite markers were transferred from the cashew, Anarcadium occidentale, to Anacardium humile (Anacardiaceae), a Neotropical shrub from the Brazilian savanna, that produces an edible nut and pseudo-fruit. We tested 14 microsatellite primers from A. occidentale on A. humile. Polymorphism of each microsatellite locus was analyzed based on 58 individ.. Read More»

Genet. Mol. Res. 12(3):

2013.January.4.24

DOI:

10.4238/2013.January.4.24

Biochemical and molecular studies of copper metabolism during the infection process of the human pathogenic fungus Paracoccidioides brasiliensis

Authors: R.S. Santos

Genet. Mol. Res. 9(1):

vol9-1TA028

DOI:

10.4238/vol9-1TA028

Benefits of kinesiotherapy and aquatic rehabilitation on sickle cell anemia. A case report

Authors: G. Tinti, R. Somera Jr., F.M. Valente and C.R.B. Domingos

The process of hemoglobin polymerization and the consequent sickling of red blood cells that occurs in patients with sickle cell disease shortens the half-life of red blood cells. It causes vaso-occlusive complications, as well as pain and pulmonary and cardiovascular dysfunction. We evaluated an aquatic rehabilitation program.. Read More»

Genet. Mol. Res. 9(1):

vol9-1gmr722

DOI:

10.4238/vol9-1gmr722

Molecular epidemiology of HFE gene polymorphic variants (C282Y, H63D and S65C) in the population of Esp�­rito Santo, Brazil

Authors: L.N.R. Alves, E.V.W. Santos, E. Stur, A.M.A. Silva Conforti and I.D. Louro

Hereditary hemochromatosis (HH) is an autosomal recessive disorder that leads to progressive iron accumulation and may cause cirrhosis, hepatocellular carcinoma, diabetes, and heart failure. Most cases of HH have been linked to mutations in genes associated with iron homeostasis. There have been three major variants in the hig.. Read More»

Genet. Mol. Res. 15(2):

gmr.15028189

DOI:

10.4238/gmr.15028189

Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran

Authors: M. Hashemi, A.K. Moazeni-Roodi, A. Fazaeli, M. Sandoughi, G.R. Bardestani, D.M. Kordi-Tamandani and S. Ghavami

Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q.. Read More»

Genet. Mol. Res. 9(1):

vol9-1gmr728

DOI:

10.4238/vol9-1gmr728

Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining

Authors: L. An, H. Xia, P. Zhou and L. Hua

Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. .. Read More»

Genet. Mol. Res. 15(2):

gmr.15028639

DOI:

10.4238/gmr.15028639