Human Genetics
Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer
Authors: D.Q. Wang, X.P. Ding, S. Yin and Y.D. Mao
The expression of interleukin-11 (IL-11) and its products STAT3 and phospho-STAT3 (p-STAT3) in patients with chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), and gastric cancer (GC) may provide insight into the diagnostic role of the IL-11/STAT3 signaling pathway in GC. Gastric mucosa specimens and serum .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027358
- DOI:
- 10.4238/gmr.15027358
Mammaglobin and maspin transcripts in blood may reflect disease progression and the effect of therapy in breast cancer
Authors: O. Bitisik, P. Saip, S. Saglam, D. Derin and N. Dalay
Detection of residual tumor cells in the circulation can provide prognostic as well as therapeutic information and help in identifying patients at high risk for developing metastases. Maspin and mammaglobin are two molecules that are specifically associated with breast cancer. We looked for mammaglobin and maspin transcripts i.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr649
- DOI:
- 10.4238/vol9-1gmr649
Association of lipase lipoprotein polymorphisms with high-density lipoprotein and triglycerides in elderly men
Authors: L.M.Q. Ara�ºjo, M.S. Cendoroglo, C.O. Gigek, E.S. Chen and M. de A.C. Smith
Lipoprotein lipase is essential for triglyceride hydrolysis. The polymorphisms S447X in exon 9 and HindIII in intron 8 have been associated with lower triglyceride levels and lower cardiovascular risk in adult men. We examined the association of these lipoprotein lipase polymorphisms with high-density lipoprotein (HDL) and tri.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr689
- DOI:
- 10.4238/vol9-1gmr689
Analysis of genetic diversity of Brassica rapa var. chinensis using ISSR markers and development of SCAR marker specific for Fragrant Bok Choy, a product of geographic indication
Authors: X.L. Shen, Y.M. Zhang, J.Y. Xue, M.M. Li, Y.B. Lin, X.Q. Sun and Y.Y. Hang
Non-heading Chinese cabbage [Brassica rapa var. chinensis (Linnaeus) Kitamura] is a popular vegetable and is also used as a medicinal plant in traditional Chinese medicine. Fragrant Bok Choy is a unique accession of non-heading Chinese cabbage and a product of geographic indication certified by the Ministry of Agriculture of C.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027557
- DOI:
- 10.4238/gmr.15027557
Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation
Authors: X.X. Zhang, R.J. Bian, J. Wang and Q.Y. Zhang
Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphism.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027599
- DOI:
- 10.4238/gmr.15027599
Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients
Authors: A. Maver, I. Medica, B. Salobir, M. Tercelj and B. Peterlin
Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology a.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr682
- DOI:
- 10.4238/vol9-1gmr682
Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis
Authors: Y. Yang, Y.Y. Luo, S. Wu, Y.D. Tang, X.D. Rao, L. Xiong, M. Tan, M.Z. Deng and H. Liu
Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of Pub.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027631
- DOI:
- 10.4238/gmr.15027631
Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients
Authors: H.X. Peng, X. Xu, R. Yang, Y.M. Chu, D.M. Yang, Y. Xu, F.L. Zhou, W.Z. Ma, X.J. Zhang, M. Guan, Z.H. Yang and Z.D. Jin
Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese pati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027689
- DOI:
- 10.4238/gmr.15027689
Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer
Authors: X. Chen, X.S. Liu, H.Y. Liu, Y.Y. Lu and Y. Li
Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027702
- DOI:
- 10.4238/gmr.15027702
A novel RUNX2 mutation (T420I) in Chinese patients with cleidocranial dysplasia
Authors: G.X. Wang, R.P. Sun and F.L. Song
Cleidocranial dysplasia (CCD) is an autosomal-dominant heritable skeletal disease caused by heterozygous mutations in the RUNX2 gene. We studied a Chinese family that included three affected individuals with CCD phenotypes; the clinical features of patients with CCD include delayed closure of fontanelles, frontal bossing, dysp.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr685
- DOI:
- 10.4238/vol9-1gmr685