Human Genetics
Lack of effect of maternal body mass index on anthropometric characteristics of newborns in twin gestations
Authors: Gloria M.D.D. Colletto and Concei�§�£o A.M. Segre
We examined the correlation between maternal prepregnancy body mass index (BMI) and newborn weight, length, BMI, and gestational order, in singleton and twin births. The sample comprised 381 mothers of multiple babies (562 twins), and 7979 singleton pregnancies, used as controls. The Mann-Whitney non-parametric test was used t.. Read More»
- Genet. Mol. Res. 4(1):
Hereditary hemochromatosis in a Brazilian university hospital in S�£o Paulo State (1990-2000)
Authors: Ana L.C. Martinelli, Rui Filho, Samantha Cruz, Rendrik Franco,Marli Tavella, Marie Secaf, Leandra Ramalho, Sergio Zucoloto, Sandra Rodrigues and Marcos Zago
Hereditary hemochromatosis (HH) is the most common genetic disease among individuals of European descent. Two mutations (845G→A, C282Y and 187C→G, H63D) in the hemochromatosis gene (HFE gene) are associated with HH. About 85-90% of patients of northern European descent with HH are C282Y homozygous. The prevalence of .. Read More»
- Genet. Mol. Res. 4(1):
Association between -174G/C and -572G/C interleukin 6 gene polymorphisms and severe radiographic damage to the hands of Mexican patients with rheumatoid arthritis: a preliminary report
Authors: S.A. Zavaleta-MuÃ?±iz, L. Gonzalez-Lopez, J.D. Murillo-Vazquez, A.M. SaldaÃ?±a-Cruz, M.L. Vazquez-Villegas, B.T. MartÃ?Ân-MÃ?¡rquez, J.C. Vasquez-Jimenez, F. Sandoval-Garcia, A.J. Ruiz-Padilla,N.S. Fajardo-Robledo, J.M. Ponce-Guarneros, A.D. Rocha-MuÃ?±oz, M.F. Alcaraz-Lopez, D. Cardona-MÃ?¼ller, S.E. Totsuka-Sutto,E.D. Rubio-Arellano and J.I. Gamez-Nava
Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these polymorphisms are associated with the severe radiographic damage observed in some RA patients, particularly those with the development of joint bone ankylosis (JB.. Read More»
- Genet. Mol. Res. 15(2):
- gmr15049017
- DOI:
- 10.4238/gmr15049017
Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population
Authors: T. Meng, Q. Ren, J.M. Wang, H. Shi, S.T. Zhang and M.T. Liu
Intervertebral disc disease is a multifactorial condition, yet disease pathogenesis that can be promoted by a single dominant mutation affecting the expression of susceptibility genes. We performed a case-control study to assess the influence of the COL9A2 Gln326Arg polymorphism on risk of intervertebral disc disease in a Chin.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048958
- DOI:
- 10.4238/gmr15048958
Analysis of ADH1B Arg47His, ALDH2 Glu487Lys, and CYP4502E1 polymorphisms in gastric cancer risk and interaction with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Gastric cancer is the fourth commonly diagnosed cancer and the second most frequent cause of cancer death worldwide. Genetic variations in ADH1B and ALDH2 may alter the function and activity of the corresponding enzymes, leading to differences in acetaldehyde exposure between drinkers. Cytochrome P4502E1 (CYP4502E1) is a phase.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048904
- DOI:
- 10.4238/gmr15048904
No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population
Authors: T. Tencomnao, V. Thongrakard, W. Phuchana, T. Sritharathikhun and S. Suttirat
Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major dep.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr823
- DOI:
- 10.4238/vol9-2gmr823
Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction
Authors: H.L. Jiang, L.Q. Cao and H.Y. Chen
Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnan.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048890
- DOI:
- 10.4238/gmr15048890
Correlation between TRAIL and caspase-8 expression and their relationship with cell proliferation and apoptosis in human osteosarcoma
Authors: X. Ning, X.W. Shang, Y. Zhuang, M. Liu, H. Yang, H. Zhang and M.Z. Huang
Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 l.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048876
- DOI:
- 10.4238/gmr15048876
Polymorphism analysis of multi-parent advanced generation inter-cross (MAGIC) populations of upland cotton developed in China
Authors: D.G. Li, Z.X. Li, J.S. Hu, Z.X. Lin and X.F. Li
Upland cotton (Gossypium hirsutum L.) is an important cash crop that provides renewable natural fiber worldwide. Currently limited genetic base leads to a decrease in upland cotton genetic diversity. Multi-parent advance generation inter-cross (MAGIC) populations can be used to evaluate complex agronomic traits in crops. In th.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048759
- DOI:
- 10.4238/gmr15048759
Investigation on the association between IL-10 C819T gene polymorphisms and susceptibility to gastric cancer
Authors: L. Li, X.Y. Tang, L.M. Ye, Q. Yang and Y. Li
We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People’s Hospital betwee.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047915
- DOI:
- 10.4238/gmr15047915