Human Genetics
Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E
Authors: J.X. Xu, L. Su, L. Chen and J.X. Lin
This study aimed to investigate the influence of acute glycemic load on vascular endothelial function in patients with hypertension and to evaluate the protective effect of vitamins C and E during the acute glycemic phase. We randomly selected 39 hypertensive patients and 21 normal subjects and divided them into 3 groups: 75 g.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.9
- DOI:
- 10.4238/2014.September.5.9
Effect of superposition and masking between red blood cell autoantibodies and alloantibodies
Authors: Y. Yu and D.Q. Wang
This study aimed to explore the law of superposition and masking between autoantibodies and alloantibodies, and to ensure the detection of alloantibodies and to improve the safety of warm autoimmune hemolytic anemia patients. Eight kinds of commercial IgG red blood cell antibody reagents were serially diluted, and 3 kinds of a.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.June.18.9
- DOI:
- 10.4238/2014.June.18.9
Construction and identification of pIRES2-LIF-NT-3 bicistronic eukaryotic expression vector
Authors: B.N. Li, W.D. Li*, J.T. Lin, H.G. Feng and Z.Q. Yuan
We used a simple and efficient method to construct a bicistronic eukaryotic expression vector pIRES2-LIF-NT-3. The leukemia inhibitory factor (LIF) and neurotrophin-3 (NT-3) genes were obtained from the genomic DNA of human peripheral blood mononuclear cells by polymerase chain reaction. The LIF cDNA fragment was inserted into.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.June.18.12
- DOI:
- 10.4238/2014.June.18.12
Construction and identification of pIRES2-VEGF165-NT-3 bicistronic eukaryotic expression vector
Authors: B.N. Li, W.D. Li, H.G. Feng, J.T. Lin and Z.Q. Yuan
We used a simple and efficient method to construct the bicistronic eukaryotic expression vector pIRES2-VEGF165-NT-3. The neurotrophin-3 (NT-3) gene was obtained from the genomic DNA of human peripheral blood mononuclear cells by polymerase chain reaction. The NT-3 cDNA fragment was cloned into the pIRES2-VEGF165-EGFP vector in.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.June.18.13
- DOI:
- 10.4238/2014.June.18.13
Role of ADH2 and ALDH2 gene polymorphisms in the development of Parkinson�s disease in a Chinese population
Authors: C.C. Zhao, H.B. Cai, H. Wang and S.Y. Pan
In this study, we investigated the role of ADH2 Arg47His and ALDH2 Glu487Lys genetic polymorphisms in the development of Parkinson’s disease in a Chinese population. Between January 2013 and May 2014, 115 patients with Parkinson’s disease and 214 healthy controls were recruited in our study. Genotyping of ADH2 Arg4.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038606
- DOI:
- 10.4238/gmr.15038606
Cytogenetic and molecular analysis of infertile Chinese men: karyotypic abnormalities, Y-chromosome microdeletions, and CAG and GGN repeat polymorphisms in the androgen receptor gene
Authors: T.T. Han, J. Ran, X.P. Ding, L.J. Li, L.Y. Zhang, Y.P. Zhang, S.S. Nie and L. Chen
Chromosome abnormalities, Y-chromosome microdeletions, and androgen receptor gene CAG and GGN repeat polymorphisms in infertile Chinese men featuring severe oligospermia and azoospermia were analyzed. Ninety-six fertile men and 189 non-obstructive infertile men, including 125 patients with azoospermia and 64 with severe oligozoospermia, were studied. Seve.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.3
- DOI:
- 10.4238/2013.July.8.3
Linkage and mapping analyses of the normal marking gene +P in the silkworm (Bombyx mori) using SSR markers
Authors: G.Q. Wei, L. Yu, C.L. Liu, B.J. Zhu and H.J. Ding
In the silkworm, Bombyx mori, normal markings are mainly controlled by the +P gene, which is located on the second chromosome. Due to a lack of crossing over in females, reciprocal backcrossed F1 (BC1) progenies were used for linkage analysis and mapping of the +P gene based on an SSR linkage map using silkworm strains P50 and H9, which are normal marking.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.22.1
- DOI:
- 10.4238/2013.January.22.1
Effect of ARMS2 gene polymorphism on intravitreal ranibizumab treatment for neovascular age-related macular degeneration
Authors: H. Bardak, Y. Bardak, Y. Ercalik, E. Turkseven Kumral, S. Imamoglu, M. Gunay, H. Ozbas and O. Bagci
Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries. The ARMS2 gene has been found to be associated with AMD. Currently, intravitreal ranibizumab (IVR) treatment is one of the widely used treatments for neovascular AMD. The aim of this study was to investigate the association between t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049164
- DOI:
- 10.4238/gmr15049164
Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis
Authors: Y.L. Wang, W.G. Gong and Q.L. Yuan
Thyroid cancer is the most common type of endocrine tumor. MicroRNAs (miRNAs) play a critical role in a variety of diseases, especially cancer occurrence and progression. However, the specific mechanism by which miRNAs trigger disease states has not been fully elucidated. This study aims to investigate the role of miR-27a in t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049070
- DOI:
- 10.4238/gmr15049070
Genetic analysis of Apuleia leiocarpa as revealed by random amplified polymorphic DNA markers: prospects for population genetic studies
Authors: K.H. Lencina, E.R. Konzen, S.M. Tsai and D.A. Bisognin
Apuleia leiocarpa (Vogel) J.F. MacBride is a hardwood species native to South America, which is at serious risk of extinction. Therefore, it is of prime importance to examine the genetic diversity of this species, information required for developing conservation, sustainable management, and breeding strategies. Although scarce.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049058
- DOI:
- 10.4238/gmr15049058