Human Genetics
Phylogeny of the Southwest Asian Pimpinella and related genera based on nuclear and plastid sequences
Authors: S. Fereidounfar, F. Ghahremaninejad and M. Khajehpiri
Pimpinella L. is a large genus and arguably one of the most complex genera in the family Apiaceae. In this study, the infra-generic relationship between Southwest Asian Pimpinella species and their generic allies in the tribe Pimpinelleae Spreng were investigated using sequence data from the cpDNA (chloroplast DNA) rps16 exon .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048767
- DOI:
- 10.4238/gmr15048767
Chloroplast DNA analysis of Tunisian cork oak populations (Quercus suber L.): sequence variations and molecular evolution of the trnL (UAA)-trnF (GAA) region
Authors: A. Abdessamad, G. Baraket, H. Sakka, Y. Ammari, M. Ksontini and A. Salhi Hannachi
Sequences of the trnL-trnF spacer and combined trnL-trnF region in chloroplast DNA of cork oak (Quercus suber L.) were analyzed to detect polymorphisms and to elucidate molecular evolution and demographic history. The aligned sequences varied in length and nucleotide composition. The overall ratio of transition/transversion (t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048749
- DOI:
- 10.4238/gmr15048749
TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese
Authors: X.M. Xu, M. Ding, H. Pang and B.J. Wang
In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nu.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.1
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.1
Effect of polymorphisms in interleukin-18 gene on the susceptibility to coronary artery disease in a Chinese population
Authors: J.B. Ma, L. Chen, B. Gao and J. Xu
Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048708
- DOI:
- 10.4238/gmr15048708
Correlation analysis of genetic diversity and population structure of Houttuynia cordata Thunb with regard to environment
Authors: J. Zhong, F.-C. Wu, P. Qiu and L.-J. Dai
To study the levels of genetic diversity, and population structure, of Houttuynia cordata Thunb, the genetic background and relationships of populations were analyzed in terms of environmental factors. The genetic diversity and population structure of H. cordata were investigated using sequence-related amplified polymorphisms and correlation with environm.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038780
- DOI:
- 10.4238/gmr.15038780
Gene-gene interaction between VANGL1, FZD3, and FZD6 correlated with neural tube defects in Han population of Northern China
Authors: R.P. Zhang, Y.L. Fang, B. Wu, M.N. Chemban, N. Laakhey, C.Q. Cai and O.Y. Shi
We evaluated the influence of gene-gene interactions between VANGL1, FZD3, and FZD6 on the risk of neural tube defects (NTDs) in Han population in the north of China. Two single nucleotide polymorphisms (SNPs) (rs4839469 and rs34059106) within VANGL1, two SNPs (rs2241802 and rs28639533) within FZD3, and three SNPs (rs827528, rs3808553, and rs12549394) wit.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039010
- DOI:
- 10.4238/gmr.15039010
Association between aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism and susceptibility to colorectal cancer: a meta-analysis
Authors: S. Zhao, X.M. Du, S.S. Ma and L.M. Wang
Numerous studies have evaluated the association between Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene and colorectal cancer (CRC) risk. However, the specific association remains controversial. To assess the relationship between the ALDH2 Glu504Lys polymorphism and CRC, we conducted a comprehensive meta-analysis of five case-control s.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037872
- DOI:
- 10.4238/gmr.15037872
Characterization of novel expressed sequence tag-simple sequence repeat markers and analysis of genetic diversity in four geographic populations of Thais luteostoma
Authors: W. Li, H.F. Jiao, Z.H. Lin, Y.B. Bao
In this study, the genetic diversity in four geographic populations (Yushan Island, Zhoushan, Wenzhou, and Xiamen) of Thais luteostoma was analyzed using 21 microsatellite loci. The results of this study showed that the alleles obtained from different populations ranged from 2 to 8. The average number of alleles and effective .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048702
- DOI:
- 10.4238/gmr15048702
Upregulation of ICAM-1 and IL-1�² protein expression promotes lung injury in chronic obstructive pulmonary disease
Authors: Y.X. Wang, M.L. Ji, C.Y. Jiang and Z.B. Qian
Chronic obstructive pulmonary disease (COPD) is a devastating lung disorder characterized by sustained airway flow restriction that is not fully reversible. The precise pathogenic mechanisms are unknown, but it is clear that cigarette smoking and chronic inflammatory stimulation are the major causes of COPD. Lung inflammation associated with COPD involves.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037971
- DOI:
- 10.4238/gmr.15037971
Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis
Authors: J. De Azevedo Silva, S.C. Lima, C. Addobbati, R. Moura, L.A. Cavalcanti Brand�£o, J.A. Tr�©s Pancoto, E.A. Donadi, S. Crovella and P. Sandrin-Garcia
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral toler.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048008
- DOI:
- 10.4238/gmr15048008