Human Genetics
Impact of citrate pretreatment on ventricular arrhythmia and myocardial capase-3 expression in ischemia/reperfusion injury
Authors: Q. Lu, Z.G. Li1,, N. Zhou, Z.G. Gong, J.Q. Jiang, Z.N. Chen, Q.J. Jiang, Y. Peng and S.F. Ding
Ischemia/reperfusion (I/R) injury often triggers ventricular arrhythmia. Citrate binds calcium ions, forming a soluble calcium citrate complex that may reduce I/R injury by affecting calcium ion concentration. We tested the effects of citrate pretreatment on ventricular heart rate and related factors in a rat I/R model. Fifty .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048848
- DOI:
- 10.4238/gmr15048848
Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population
Authors: R. Lakhdar, S. Denden, J. Knani, N. Leban, H. Daimi, M. Hassine, G. Lefranc, J. Ben Chibani and A. Haj Khelil
Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved i.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr770
- DOI:
- 10.4238/vol9-2gmr770
Association between IL6 polymorphism and risk of cerebral infarction
Authors: Y.H. Han
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population. This study included 305 cerebral infarction patients and 326 control subjects enrolled between May 2012 and May 2014. The genotyping of IL6 -174G/C (rs1800795).. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Self-declared ethnicity and genomic ancestry in prostate cancer patients from Brazil
Authors: J.S. Oliveira, R.S. Ferreira, L.M. Santos, L.J. Marin, R.X. Corr�?ªa, M.R. Luizon, A.L. Sim�?µes, S.R. Gadelha and S.M.B. Sousa
Some studies of polymorphisms in prostate cancer (PCa) analyze individuals in a uniform manner, regardless of genetic ancestry. However, PCa aggressiveness differs between subjects of African descent and those of European extraction. Thus, genetic ancestry analysis may be used to detect population stratification in case-contro.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048769
- DOI:
- 10.4238/gmr15048769
GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer
Authors: A.L. Oliveira, F.F.O. Rodrigues, R.E. Santos, T. Aoki, M.N. Rocha, C.A. Longui and M.B. Melo
The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associat.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr726
- DOI:
- 10.4238/vol9-2gmr726
Correlation of plasma soluble cluster of differentiation 40 ligand, alpha fetoprotein A, and pregnancy-associated plasma protein A with carotid plaque in patients with ischemic stroke
Authors: Y.J. Wang, Z.Q. Gong, X.M. Bi and Y.L Li
This study investigated the correlation of plama levels of inflammatory biomarkers [soluble cluster of differentiation 40 ligand (sCD40L), alpha fetoprotein A (fetuin-A), and pregnancy-associated protein A (PAPP-A)] with carotid plaque in patients with acute ischemic stroke. After undergoing color Doppler ultrasonography of the bilateral carotid arteries,.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.18
- DOI:
- 10.4238/2015.July.17.18
Correlation between neuronal antibodies and limbic encephalitis in Chinese Han subjects
Authors: Q.M. Chen, H.D. Qu, W.D. Qian, L. Shen, L. Xu, Y.H. Chen,D.Q. Sang, L.N. Zhang, L. Yin, L. Li and H. Wang
A variety of anti-neuronal cell membrane antibodies such as voltage-gated potassium channel antibody, N-methyl-D-aspartate-2B-antibody, and glutamic acid decarboxylase antibody, are correlated with limbic encephalitis (LE). In this study on patients with LE, the clinical manifestations, psychology Wechsler Adult Intelligence Scale, cerebrospinal fluid, el.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.16
- DOI:
- 10.4238/2015.March.27.16
Expression of STK39 in peripheral blood of hypertension patients and the relationship between its genetic polymorphism and blood pressure
Authors: B. Li, M. Yang and J.W. Liu
This study investigated the STK39 expression in peripheral blood of hypertension patients and the relation between its genetic polymorphism and blood pressure. The observation group comprised of 42 primary hypertension patients admitted to our hospital, and the control group comprised of 30 healthy individuals who underwent physical examination in our hos.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population
Authors: J. Guo, H.C. Lv, R.H. Shi and W.L. Liu
Osteosarcoma is one of the most common bone malignancies in adolescents, and hereditary factors may influence its susceptibility. We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population. Between May 2012 and May 2014, a total of 136 osteosarcoma patients and 136 healthy control subjects w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies
Authors: Q. Wang, N.Y. Wang, X.M. Cao, X. Sun, D. Shen, M. Yuan and J.F. Chen
Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A co.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038218
- DOI:
- 10.4238/gmr.15038218