Human Genetics
Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
Authors: K. Yu, Y. Ji, H. Wang, Q.K. Xuan, B.B. Li, J.J. Xiao, W. Sun and X.Q. Kong
We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048929
- DOI:
- 10.4238/gmr15048929
Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis
Authors: B.-S. Li, H. Liu and W.-L. Yang
microRNA-218 (miR-218) is a vertebrate-specific miRNA that plays a crucial role in tumorigenesis and tumor progression. This study analyzed the miR-218 expression level and clinical significance in pancreatic cancer. One hundred and seven pairs of pancreatic cancer and adjacent normal tissues were analyzed by quantitative reverse-transcriptase polymerase .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Serious pulmonary infection in a splenectomized patient with adult type 1 Gaucher disease
Authors: Y. Zhang, Y.F. Mao and J.M. Du
A 49-year-old man with a history of Gaucher disease type 1, resulting in serious splenomegaly and eating disorder, was referred to our department and underwent a splenectomy under general anesthesia. Gaucher disease is very rare, and its first signs are unexplained splenomegaly and hypersplenism. On preoperative examination, the patient’s platelet c.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.13
Association between IL-4 gene polymorphisms, IL-4 serum levels, and ankylosing spondylitis
Authors: X.L. Liu, J.K. Ren and Y.L. Su
We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the c.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048898
- DOI:
- 10.4238/gmr15048898
Conventional and contrast-enhanced ultrasound assessment of craniocerebral gunshot wounds
Authors: D. Deng, G. Dan, J. Tao, X.-B. Wu, Z. Chen, M. Chang, M.-S. Liao and F. He
This study aimed to investigate the characteristic features of craniocerebral gunshot wounds by conventional ultrasound (CUS) and evaluate the efficacy of contrast-enhanced ultrasound (CEUS) in differentiation of tissue condition in wounds. Twenty crossbreed dogs (treatment: N = 15; control: N = 5) were used in the study. Pipe-shaped hyperechoes of varyin.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.14
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.14
Calpain-10 gene polymorphisms and risk of type 2 diabetes mellitus in Mexican mestizos
Authors: V.J. Picos-CÃ?¡rdenas , E. SÃ?¡inz-GonzÃ?¡lez , A. Miliar-GarcÃ?Âa ,A. Romero-Zazueta, R. Quintero-Osuna, E. Leal-Ugarte,V. Peralta-Leal and J.P. Meza-Espinoza
The calpain-10 gene is expressed primarily in tissues important in glucose metabolism; thus, some of its polymorphisms have been associated with type 2 diabetes. In this study, we examined the association between the calpain-10 single-nucleotide polymorphism (SNP)-43, SNP-19, and SNP-63 and type 2 diabetes in Mexican mestizos. We included 211 patients and.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.6
- DOI:
- 10.4238/2015.March.27.6
Intestinal alkaline phosphatase and sodium butyrate may be beneficial in attenuating LPS-induced intestinal inflammation
Authors: A.D.B. Melo, H. Silveira, C. Bortoluzzi, L.J. Lara, C.A.P. Garbossa, G. Preis, L.B. Costa and M.H. Rostagno
In this study, we evaluated the effect of intestinal alkaline phosphatase (IAP) and sodium butyrate (NaBu) on lipopolysaccharide (LPS)-induced intestinal inflammation. Intestinal alkaline phosphatase and RelA/p65 (NF-κB) gene expressions in porcine jejunum explants were evaluated following exposure to sodium butyrate (Na.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048875
- DOI:
- 10.4238/gmr15048875
Abnormal gene expression profile reveals the common key signatures associated with clear cell renal cell carcinoma: a meta-analysis
Authors: H.J. Zhang, Z.Q. Sun, W.Q. Qian and L. Sheng
The aims of this study were to identify the common gene signatures of clear cell renal cell carcinoma (CCRCC), and to expand the respective protein-protein interaction networks associated with CCRCC regulation. For the latter, we utilized multiple gene expression data sets from the National Center for Biotechnology Information (NCBI) Gene Expression Omnib.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.7
- DOI:
- 10.4238/2015.March.27.7
Case study of a patient presenting both type II bipolar affective disorder and Klinefelter syndrome
Authors: H. Delavenne, J.M. Khoury, F. Thibaut and F.D. Garcia
Klinefelter syndrome (KS) is the most common sex chromosomal disorder with an estimated prevalence of 1 in 500-1000. Increased incidences of anxiety, depression, substance abuse, psychotic and behavioral disorders, and sexual disorders have been reported in patients with KS. The aim of this case study was to report a case of a.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048872
- DOI:
- 10.4238/gmr15048872
Association between growth differentiation factor-15 and chronic heart failure in coronary atherosclerosis patients
Authors: Z.D. Zhu and T. Sun
We explored the association between plasma growth differentiation factor 15 (GDF-15) levels and chronic heart failure (CHF) in coronary heart disease patients. We measured plasma GDF-15 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in 269 untreated coronary heart disease patients (98 with CHF, 84 without CHF, and 87 control patients) us.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.8
- DOI:
- 10.4238/2015.March.27.8