Human Genetics
Phosphorylation of the GluN1 subunit in dorsal horn neurons by remifentanil: a mechanism for opioid-induced hyperalgesia
Authors: C. Zhang, S.S. Li, N. Zhao and C. Yu
Remifentanil (an ultra-short acting μ-opioid receptor agonist) use has been associated with acute opioid tolerance and hyperalgesia. Previous electrophysiological studies have shown that remifentanil elicits rapid and prolonged upregulation of N-methyl-D-aspartate receptor (NMDAR) currents. However, the effect of remifentanil on the levels of the GluN1.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.13
- DOI:
- 10.4238/2015.March.13.13
Fetal fibronectin detection for preterm birth prediction
Authors: L. Gao, J.P. Zhang, H. Chen, Z.J. Guo, L.B. Chen, J.P. Tan,Y.H. Wang, R. Zhang, Y.L. Liu and W.B. Cai
To study preterm birth prediction based on fetal fibronectin (fFN) in pregnant women, we randomly selected 124 patients. Vaginal posterior fornix secretions were analyzed using fFN quick test strips. Leucorrhea routine samples were collected to detect bacterial vaginosis, mycoplasma, and chlamydia. Delivery data at 7 days, 14 .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.4
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.4
Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus
Authors: Q. Li, Z.R. Qiao, D.B. Liu, J.T. Zeng, J. Zhang, Y. Bo, H.Y. Zu, Q. Hu, X. Wu and S.S. Dong
In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid decarboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untran.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.10
Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure
Authors: X.F. Zhao, Y. Xu, Z.Y. Zhu, C.Y. Gao and Y.N. Shi
The aim of this study was to evaluate the effectiveness of umbilical cord mesenchymal stem cells (MSCs) in the treatment of chronic systolic heart failure. Fifty-nine hospitalized patients with heart failure were randomly divided into a treatment group (30 patients) and a control group (29 patients). The treatment group received treatment with medication .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.11
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.11
Germline HVR-II mitochondrial polymorphisms associated with breast cancer in Tunisian women
Authors: B. Yacoubi Loueslati, W. Troudi, L. Cherni, K.B. Rhomdhane and L. Mota-Vieira
A high incidence of somatic mtDNA polymorphisms has been reported in a wide variety of human cancers; some of them have been proposed as markers for the early detection of breast cancer. However, little attention has been paid to the potential of germline mitochondrial sequence variations as genetic risk factors for cancer. We.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr778
- DOI:
- 10.4238/vol9-3gmr778
Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population
Authors: Y.Z. Dong, Y.X. Huang and T. Lu
In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the con.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.18
- DOI:
- 10.4238/2015.March.13.18
Protective effect of ischemia preconditioning on ischemia-reperfusion injury in rat liver transplantation
Authors: Z.S. Qing, X.S. Zhang, C.C. Gao, W.D. Liu, T.F. Xia, K. Wu and L.Q. Pang
We explored the protective effect of ischemia preconditioning (IP) on ischemia-reperfusion injury in rat liver transplantation. An orthotopic liver transplantation model was utilized in the study. A total of 54 Sprague-Dawley rats were divided into a control group (group A, no liver transplantation), liver transplantation group (group B, heparin Ringer&rs.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.12
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.12
A small supernumerary marker chromosome, derived from chromosome 22, possibly associated with repeated spontaneous abortions
Authors: M. Balkan, H. �°si, A. Gedik, M. Erdemo��lu and T. Budak
We report a phenotypically normal couple with repeated spontaneous abortions and without other clinical features. Clinical, hematological, biochemical, and endocrinological aspects of the couple did not reveal any abnormalities. The karyotype of the wife was normal (46,XX), while the husband was found to have an abnormal karyo.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr947
- DOI:
- 10.4238/vol9-3gmr947
Genetic variations of ISL1 associated with human congenital heart disease in Chinese Han people.
Authors: Z.L. Luo, H. Sun, Z.Q. Yang, Y.H. Ma, Y. Gu, Y.Q. He, D. Wei4, L.B. Xia, B.H. Yang and T. Guo
Congenital heart disease (CHD) is the most common birth abnormality, but the etiology of CHD is unknown. ISL1 may play a fundamental role in cardiac morphogenesis, and mutations of this gene could cause CHD. To evaluate whether genetic variations of ISL1 are associated with CHD in Chinese Han people, polymerase chain reaction .. Read More»
- Genet. Mol. Res. 13(1):
Phylogenetic relationships among Saccharum clones in Pakistan revealed by RAPD markers
Authors: S. Nawaz, F.A. Khan, S. Tabasum, M. Zakria, A. Saeed and M.Z. Iqbal
Forty sugarcane genotypes (clones), including elite lines, commercial cultivars of Saccharum officinarum and S. barberi clones, were fingerprinted with 30 RAPD markers, using a PCR-based marker assay. The genetic distance for RAPD data was determined according to Nei, and relationships between accessions were graphed in a dend.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr903
- DOI:
- 10.4238/vol9-3gmr903