Human Genetics
Meta-analysis of epidemiological studies of association of P53 codon 72 polymorphism with bladder cancer
Authors: D.B. Li, X. Wei, L.H. Jiang, Y. Wang and F. Xu
Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597 bladder cancer cases and 731 controls. Patients with bladder cancer had a s.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr882
- DOI:
- 10.4238/vol9-3gmr882
Clinical value of fluid bolus contrast flow meter during hysterosalpingography
Authors: Y.P. Ji, Y. Xu, S.Z. Xia, F.Y. Bian, H. Zhang and G.H. Shen
The purpose of this study was to investigate the clinical value of the fluid bolus contrast flow meter during hysterosalpingography. Hysterosalpingography information of 342 cases, which included a manual handset group of 213 cases and a bolus instrument group of 129 cases were reviewed. Comparative analysis was used to compare the two groups in order to .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.19
- DOI:
- 10.4238/2015.March.6.19
Correlation analysis of the PNPLA7 gene polymorphism and susceptibility to menstrual disorder
Authors: Y. Su, G.L. Kong, Y.L. Su, Y. Zhou, L.F. Lv, Q. Wang, B.P. Huang,R.Z. Zheng, Q.Z. Li, H.J. Yuan and Z.G. Zhao
We examined the correlation between PNPLA7 gene polymorphisms at the rs61754920 and rs11137410 loci and menstrual disorder in women of reproductive age in the Central Plain. Genomic DNA was extracted from peripheral blood; polymerase chain reaction-ligase detection reaction and SNaPshot genotyping were used to detect polymorphisms in the rs61754920 and rs.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.20
- DOI:
- 10.4238/2015.March.6.20
Mechanism of the reversal effect of mifepristone on drug resistance of the human cervical cancer cell line HeLa/MMC
Authors: H. Chen, J. Duan and F. Zuo
We examined the ability of mifepristone to reverse the in vitro drug resistance of human cervical cancer cells resistant to mitomycin-C (HeLa/MMC) cells and investigated the mechanism of this effect. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to detect the drug resistance of HeLa/MMC cel.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.27.14
- DOI:
- http://dx.doi.org/10.4238/2014.February.27.14
Association between the FGB gene polymorphism and ischemic stroke: a meta-analysis
Authors: X.F. Zhang and T.Y. Luo
To clarify the relationship between the β-fibrinogen (FGB) genetic polymorphism (-148C>T) and ischemic stroke, we identified studies by searching PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CKNI) databases. Data from eligible studies were extracted and subjected to meta-analysis. Publication bias was tested using a funnel pl.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.21
- DOI:
- 10.4238/2015.March.6.21
Puerarin prevents inflammation and apoptosis in the neurocytes of a murine Parkinson�s disease model
Authors: M. Jiang, Q. Yun, G. Niu, Y. Gao, F. Shi and S. Yu
The aim of this study was to investigate Parkinson’s disease (PD) using a murine model of PD. Specifically, we aimed to explore the mechanism by which puerarin prevents inflammation and apoptosis in neurocytes. Eighty healthy male C57/BL6 mice were randomly selected and divided into four groups (N = 20 each): control gro.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15047501
- DOI:
- 10.4238/gmr.15047501
Comparison of three methods of DNA extraction from peripheral blood mononuclear cells and lung fragments of equines
Authors: E.M. Santos, J.F.R. Paula, P.M.C. Motta, M.B. Heinemann, R.C. Leite, J.P.A. Haddad, H.L. Del Puerto and J.K.P. Reis
We compared three different protocols for DNA extraction from horse peripheral blood mononuclear cells (PBMC) and lung fragments, determining average final DNA concentration, purity, percentage of PCR amplification using β-actin, and cost. Thirty-four samples from PBMC, and 33 samples from lung fragments were submitted to.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr818
- DOI:
- 10.4238/vol9-3gmr818
Association between the LXR�± polymorphism and stroke in a Chinese population
Authors: J.S. Yang, J.J. Hao, S.S. Wang, Z.F. Zhu, Q. Fang, H. Bao and H.P. Zhang
We examined the relationship between the liver X receptor α gene (LXRα) polymorphism and the susceptibility to stroke. We utilized the single fluorescent-labeled probe technique to detect the genotype of rs12221497 in the LXRα gene in 400 stroke patients and 400 healthy control subjects. The difference in genotype distribution between th.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.2
- DOI:
- 10.4238/2015.March.13.2
Multibreed genetic evaluation in bovines using simulated data employing a composite population
Authors: A.L. Bocchi, H.N. Oliveira, J.B.S. Ferraz and J.P. Eler
Genetic evaluations in Brazil are performed within each animal breed; however, with the wide range of extant genetic groups in the country and the increased use of genetic crossing as a form of rapid meat production, more elaborate programs that can jointly evaluate animals of different genetic groups are needed. Genetic evalu.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048382
- DOI:
- 10.4238/gmr.15048382
Genetic divergence through joint analysis of morphoagronomic and molecular characters in accessions of Jatropha curcas
Authors: C.N. Pestana-Caldas, S.A. Silva, E.L. Machado, D.R. de Souza,E.C. Cerqueira-Pereira and M.S. Silva
The aim of this study was to investigate the genetic divergence between accessions of Jatropha curcas through joint analysis of morphoagronomic and molecular characters. To this end, we investigated 11 morphoagronomic characters and performed molecular genotyping, using 23 inter-simple sequence repeat (ISSR) primers in 46 acce.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048385
- DOI:
- 10.4238/gmr.15048385