Human Genetics
Cytogenetic damage in the buccal epithelium of Brazilian aviators occupationally exposed to agrochemicals
Authors: L.B. Minasi, E.O.A. Costa, D.M. Silva, C.O.A. Melo, J.G. de Almeida, T.C. Vieira, R.L. Silva J�ºnior, C.L.Ribeiro, C.C. da Silva and A.D. da Cruz
The frequency of micronuclei in both buccal cells and peripheral blood lymphocytes is extensively used as a biomarker of chromosomal damage and genome stability in human populations. We examined whether prolonged exposure to complex mixtures of Short Communication pesticides leads to an increase in cytogenetic damage. The expo.. Read More»
- Genet. Mol. Res. 10(4):
Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4
Authors: W. Zhou, H. Lv, M.X. Li, H. Su, L.G. Huang, J. Li and W.M. Yuan
We established a necrotizing enterocolitis (NEC) rat model and explored the role of bifidobacteria in the intestines of the rats and its regulation on intestinal Toll-like receptors (TLRs). Seventy-five newborn Sprague-Dawley rats were randomly divided into 5 groups (15 rats/group): group A, artificial feeding group (formula-fed); group B, NEC model (LPS .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.2
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.2
Decreased expression of humanized Fat-1 in porcine fetal fibroblasts following deletion of PGK-neomycin resistance
Authors: X.J. Han, H. Liang, T. Yun, Y.H. Zhao, M.L. Zhang, L.H. Zhao, R.F. Li and X.L. Li
The neomycin-resistance (neor) gene is widely used as a selectable marker in eukaryotic expression vectors; however, its expression often affects that of target genes. Cre recombinase recognizes LoxP sites, leading to site-specific recombination and deletion of DNA and RNA between two LoxP sites. In the present study, a humanized Fat-1 gene (hFat-1) was g.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.11
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.11
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population
Authors: H. Li, W.L. Xu, H.L. Shen, Q.Y. Chen, L.L. Hui, L.L. Long and X.L. Zhu
Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a po.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.8
- DOI:
- 10.4238/2011.December.14.8
Treatment of moyamoya disease by multipoint skull drilling for indirect revascularization combined with mobilization of autologous bone marrow stem cells
Authors: R. Wu, N. Su, Z. Zhang and F. Jia
This study discusses the clinical efficacy of multipoint skull drilling for indirect revascularization combined with mobilization of autologous bone marrow stem cells and use of simvastatin in the treatment of moyamoya disease. Seventy-eight patients [control group (group A), 39 patients; experimental group (group B), 39 patients] with moyamoya disease we.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.27
- DOI:
- 10.4238/2015.July.3.27
Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and T.L. Dong
Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.28
- DOI:
- 10.4238/2015.July.3.28
Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis
Authors: D. Wu, Y. Wu, J.L. Liu3, B. Wang and X.D. Zhang
Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a meta-analysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 p.. Read More»
- Genet. Mol. Res. 10(4):
Diagnosis of lymph node micrometastasis at the pN0 stage of lung adenocarcinoma using a combination of markers
Authors: H. Liu, Y.-K. Ye, G.-M. Li, Y. Zhou, K.-B. Han, G. Xu and D. Wang
This study aimed to detect micrometastatic tumor cells in the lymph nodes of patients with pN0 lung adenocarcinoma using a combination of thyroid transcription factor-1 (TTF-1) expression and cytokeratin 7 (CK7) expression and to investigate the association of lymph node micrometastasis with the clinicopathological characteris.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.14
- DOI:
- 10.4238/2014.July.25.14
Inhibitory effects of a dendritic cell vaccine loaded with radiation-induced apoptotic tumor cells on tumor cell antigens in mouse bladder cancer
Authors: X.F. Xie, Q. Ding, J.G. Hou, G. Chen
Herein, the preparation of a dendritic cell (DC) vaccine with radiation-induced apoptotic tumor cells and its immunological effects on bladder cancer in C57BL/6 mice was investigated. We used radiation to obtain a MB49 cell antigen that was sensitive to bone marrow-derived DCs to prepare a DC vaccine. An animal model of tumor-bearing mice was established .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.30
- DOI:
- 10.4238/2015.July.3.30
CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum
Authors: K.F. Ma, X.G. Zhang and H.Y. Jia
The objective of this study was to evaluate the genotype and allelic frequencies of CYP1A2 in Chinese patients with acute liver injury induced by Polygonum multiflorum. We examined the clinical mechanism of acute liver injury induced by P. multiflorum. According to the diagnostic criteria for drug-induced liv.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.19
- DOI:
- 10.4238/2014.July.25.19