Human Genetics

Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

Authors: Y. Yang, J.R. Xu, X.M. Liu, J. Zhou, B. Yang, M. Li and Y.J. Wang,

In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects .. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.February.27.6

DOI:

http://dx.doi.org/10.4238/2014.February.27.6

Adaptive evolution of duplicated hsp17 genes in wild barley from microclimatically divergent sites of Israel

Authors: T. Zhang, G.R. Li, Z.J. Yang and E. Nevo

Gene duplication is a major evolutionary driving force for establishing new gene functions. However, very little is known about the involvement of the structural divergence of recent duplicated genes in local adaptation. We evaluated the nucleotide variation of recent duplicated pair copies of the hsp17 locus for small heat sh.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.February.27.7

DOI:

http://dx.doi.org/10.4238/2014.February.27.7

Overexpression of Arabidopsis HsfA1a enhances diverse stress tolerance by promoting stress-induced Hsp expression

Authors: J. Qian, J. Chen, Y.F. Liu1, L.L. Yang, W.P. Li1 and L.M. Zhang

Arabidopsis (Arabidopsis thaliana) group A1 heat shock factors (Hsfs), including HsfA1a, are important regulators in the heat shock response. Previous studies have revealed that genetically engineered HsfA1 members result in constitutive Hsf activation and heat shock protein gene (Hsp) expression under normal conditions, event.. Read More»

Genet. Mol. Res. 13(1):

http://dx.doi.org/2014.February.27.8

DOI:

http://dx.doi.org/10.4238/2014.February.27.8

Le(a-b-) phenotype: potential risk factor for infection by the RH strain of Toxoplasma gondii in pregnancy

Authors: F. Nakashima

Genet. Mol. Res. 9(3):

vol9-3ta032

DOI:

10.4238/vol9-3ta032

Effect of pulsed electromagnetic field therapy on the osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells

Authors: T. Lu, Y.X. Huang, C. Zhang, M.X. Chai and J. Zhang

We investigated the effects of pulsed electromagnetic fields (PEMFs) of 20 Hz/2 mT on the osteogenic and adipogenic differentiation of bone marrow stem cells (BMSCs). Sprague Dawley rat BMSCs were isolated and cultured in vitro. The BMSCs of the third passage were obtained and stimulated by PEMFs of 20 Hz/2 mT. The alkaline phosphatase (ALP) activity was .. Read More»

Genet. Mol. Res. 14(3):

http://dx.doi.org/2015.September.28.5

DOI:

http://dx.doi.org/10.4238/2015.September.28.5

Tetraploidization in Wilms tumor in an infant

Authors: E.T. Valera*, M.S. Brassesco*, C.A. Scrideli and L.G. Tone

Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones .. Read More»

Genet. Mol. Res. 9(3):

vol9-3gmr880

DOI:

10.4238/vol9-3gmr880

Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edema

Authors: A.L. Wu, Y.S. Xiong, Z.Q. Li, Y.G. Liu, Q. Quan and L.J. Wu

This study aimed to explore the relationship between genetic changes and high-altitude pulmonary edema (HAPE) susceptibility, and to screen for the key single nucleotide polymorphism (SNP) loci in the HAPE-susceptibility gene, by investigating the SNPs occurring in hypoxia-related genes in HAPE-susceptible and control (non-susceptible) populations. This r.. Read More»

Genet. Mol. Res. 14(3):

http://dx.doi.org/2015.September.28.8

DOI:

http://dx.doi.org/10.4238/2015.September.28.8

Different responses to doxorubicin-induced chromosome aberrations in Brazilian deer species

Authors: D.S.F. Vargas-Munar, J.A. Sarria-Perea and J.M.B. Duarte

The tendency toward chromosome fragility is one of the theories that may explain chromosome variation in brocket deer species (genus Mazama). We tested doxorubicin as an inducer of chromosome aberrations in lymphocytes of three brocket deer species, Mazama gouazoubira, M. americana and M. nana, compared to the marsh deer, Blas.. Read More»

Genet. Mol. Res. 9(3):

vol9-3gmr822

DOI:

10.4238/vol9-3gmr822

Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia

Authors: X.L. Su, H.R. Dong, M.R. Yan, H.W. Cui, L. Yang and F.Q. Han

We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cho.. Read More»

Genet. Mol. Res. 10(4):

2011.December.12.2

DOI:

10.4238/2011.December.12.2

No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population

Authors: L.P. Sun*, X.L. Ma*, H.X. Liu, Y.S. Wang and X.F. Li

Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter.. Read More»

Genet. Mol. Res. 9(3):

vol9-3gmr914

DOI:

10.4238/vol9-3gmr914