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Molecular characterization and expression patterns of the big defensin gene in freshwater mussel (Hyriopsis cumingii)
Authors: G.-L. Wang, X.-L. Xia, X.-L. Li, S.-J. Dong and J.-L. Li
Antimicrobial peptides (AMPs), of which big defensins are examples, are an important component of the natural defenses of most living organisms, and possess remarkable microbicidal activities. In the present study, using expressed-sequence tag sequences from a cDNA library and RACE, the full-length cDNA sequence of the big def.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.29.1
- DOI:
- 10.4238/2014.January.29.1
Mapping of AFLP loci linked to tolerance to cowpea golden mosaic virus
Authors: M.A. Rodrigues C.A.F. Santos J.R.F. Santana
AFLP markers combined with the bulk segregant analysis methodology was used for the identification of molecular markers associated with the cowpea golden mosaic virus (CGMV) resistance gene in 286 F2 cowpea plants derived from the cross IT97K-499-35 x Canapu T16. Segregation data in the F2 population demonstrated that tolerance to CGMV is controlled by a sin.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.August.17.12
- DOI:
- 10.4238/2012.August.17.12
Decoherence in yeast cell populations and its implications for genome-wide expression noise
Authors: M.R.S. Briones F. Bosco
Gene expression “noise” is commonly defined as the stochastic variation of gene expression levels in different cells of the same population under identical growth conditions. Here, we tested whether this “noise” is amplified with time, as a consequence of decoherence in global gene expression profiles (.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr531
- DOI:
- 10.4238/vol8-1gmr531
Hypertension-mediated enhancement of JNK activation in association with endoplasmic reticulum stress in rat model hippocampus with cerebral ischemia-reperfusion
Authors: Y.N. Zhao, J.M. Li, C.X. Chen, P. Zhang and S.X. Li
Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.10
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.10
Development and characterization of microsatellite loci for Ocotea species (Lauraceae) threatened with extinction
Authors: E.M. Martins, G. Martinelli, M.P. Arbetman, R.W. Lamont, J.L. Sim�µes-Ara�ºjo, D. Powell, M. Ciampi-Guillardi, C. Baldauf, A. Quinet, P. Galisa and A. Shapcott
The Atlantic rainforest species Ocotea catharinensis, Ocotea odorifera, and Ocotea porosa have been extensively harvested in the past for timber and oil extraction and are currently listed as threatened due to overexploitation. To investigate the genetic diversity and population structure of these sp.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.6
- DOI:
- 10.4238/2014.July.7.6
Genetic diversity of natural populations of Anemopaegma arvense (Bignoniaceae) in the Cerrado of S�£o Paulo State, Brazil
Authors: A.P. Batistini, M.P.C. TellesB.W. BertoniJ. da S. Coppede F.V. M�´ro, S. de C. Fran�§a, A.M.S. Pereira
Catuaba (Anemopaegma arvense), a Bignoniaceae species endemic to Cerrado regions, shows anticancer properties and is widely used as a stimulant in traditional medicine. We evaluated the genetic diversity of seven populations found in the State of São Paulo, using random amplified polymorphic DNA markers. After optimizat.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr538
- DOI:
- 10.4238/vol8-1gmr538
Global gene expression profile in myelodysplastic syndromes using SAGE
Authors: C.F. Mendiburu, W.A. Silva Jr., O. Ricci Jr., C.R. Bonini-Domingos and A.C. Fett-Conte
The molecular pathogenesis of myelodysplastic syndromes (MDS) is poorly understood. In order to expand our knowledge of genetic defects in MDS, we determined the overall profile of genes expressed in bone marrow from patients with refractory anemia with excess blasts (RAEB) by serial analysis of gene expression (SAGE). The present report describes a parti.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr521
- DOI:
- 10.4238/vol7-4gmr521
Transcriptional analysis of atrial and ventricular muscles from rats
Authors: Y. Zhi3*, Z. Cao2*, Q.H. Li1, X.L. Li1, Y. Sun1, T. Zhang1 and Q. Zhang1
Previous studies have used microarray technology to explore gene expression differences between the atrium and the ventricle. However, selection criteria for the differentially expressed genes (DEGs) based only on either the fold change or the P value in these studies. Here, we aim to further identify the DEGs by setting a P value threshold of 2, which ma.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017330
- DOI:
- 10.4238/gmr.15017330
An improved extraction protocol for metagenomic DNA from a soil of the Brazilian Atlantic Rainforest
Authors: J.H. Amorim, T.N.S. Macena, G.V. Lacerda-Junior, R.P. Rezende, J.C.T. Dias, M. Brendel and J.C.M. Cascardo
The need for the prospecting for and identification of new biomolecules is a reality. Molecular techniques allow access to the metabolic potential of microorganisms via the isolation of DNA from environmental samples, i.e., without the application of microbial culture techniques. With its great biological diversity, the Atlantic Rainforest biome has a soi.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr509
- DOI:
- 10.4238/vol7-4gmr509
Serum levels of high-sensitivity troponin T: a novel marker for left ventricular remodeling and performance in hypertensive subjects
Authors: D.M. Miao, L.P. Zhang*, H.P. Yu*, J.Y. Zhang, W.K. Xiao and P. Ye
It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.7
- DOI:
- 10.4238/2014.July.7.7