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Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population
Authors: H.M. Wang, N.F. Li, J. Hong, L. Zhou and J.H. Chang
Genetic variation is thought to contribute to etiology of metabolic syndrome (MS). Neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L) is a candidate gene for MS. This study investigated the relationship between variations of NEDD4L and MS in the Kazakh, which is an ideal population to study the .. Read More»
- Genet. Mol. Res. 12(1):
- 2014.January.8.1
- DOI:
- 10.4238/2014.January.8.1
Identification of three distinguishable phenotypes in golden retriever muscular dystrophy
Authors: C.E. Ambr�³sio, L. Fadel, T.P. Gaiad, D.S. Martins, K.P.C. Ara�ºjo,E. Zucconi, M.P. Brolio, R.F. Giglio, A.C. Morini, T. Jazedje,T.R. Froes, M.L.T. Feitosa, M.C. Valadares, P.C.B. Beltr�£o-Braga,F.V. Meirelles and M.A. Miglino
Duchenne muscular dystrophy (DMD) is a human disease characterized by progressive and irreversible skeletal muscle degeneration caused by mutations in genes coding for important muscle proteins. Unfortunately, there is no efficient treatment for this disease; it causes progressive loss of motor and muscular ability until death.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr581
- DOI:
- 10.4238/vol8-2gmr581
Elucidating the function and tolerance mechanism of gamma delta (�³ �´) T cells in a Helicobacter pylori infection model
Authors: T.E. Chen, X.M. Xu, P. Liu, S.Y. Liang and W.X. Lv
In this study, the functions and mechanisms of γ δ T cells were analyzed in patients infected with Helicobacter pylori. Peripheral blood was collected from gastritis patients in the Gastroenterology Department of Ningbo No. 2 Hospital. Preliminary analyses revealed 24 H. pylori-positive and 17 H. pylori-negative patients. The wild-type and &ga.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.16
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.16
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response
Authors: L. Yang, X.W. Wang, L.P. Zhu, H.L. Wang, B. Wang, T. Wu, Q. Zhao, D.L.X.T. JinSiHan and X.Y. Wang
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorph.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038679
- DOI:
- 10.4238/gmr.15038679
Identification and functional analysis of differentially expressed genes related to obesity using DNA microarray
Authors: J.Y. Du, H. Yang, D.R. Tian, Q.M. Wang and L. He
We looked for differentially expressed genes at different stages of preadipocyte differentiation and examined their functions, based on DNA microarrays of preadipocytes obtained from healthy subjects undergoing cosmetic liposuction. We downloaded gene expression profile GSE25910 from the Gene Expression Omnibus database and id.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.5
- DOI:
- 10.4238/2014.January.8.5
Identification of nutrient-dependent changes in extracellular pH and acid phosphatase secretion in Aspergillus nidulans
Authors: J.S. Freitas, E.M. Silva, A. Rossi
The present study was designed to identify nutrient-dependent changes in extracellular pH and acid phosphatase secretion in the biA1 palC4 mutant strain of Aspergillus nidulans. The palC4 mutant was selected as lacking alkaline phosphatase, but having substantially increased acid phosphatase activity when grown on solid minima.. Read More»
- Genet. Mol. Res. 6(3):
Toxoplasma gondii rhoptry protein 38 gene: sequence variation among isolates from different hosts and geographical locations
Authors: Y. Xu, N.Z. Zhang, J. Chen, G.H. Liu, Q.M. Xu, D.H. Zhou and X.Q. Zhu
Toxoplasma gondii is an obligate intracellular parasite that is able to infect almost all mammalian species, and may lead to toxoplasmosis of the host. In the present study, we examined sequence variation in rhoptry protein 38 (ROP38) genes among T. gondii isolates collected from different hosts and geographi.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.January.14.3
- DOI:
- 10.4238/2014.January.14.3
A novel method for identifying SNP disease association based on maximal information coefficient
Authors: H.M. Liu, N. Rao, D. Yang, L. Yang, Y. Li and F. Ou
To improve single-nucleotide polymorphism (SNP) association studies, we developed a method referred to as maximal information coefficient (MIC)-based SNP searching (MICSNPs) by employing a novel statistical approach known as the MIC to identify SNP disease associations. MIC values varied with minor allele frequencies of SNPs and the odds ratios for diseas.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.19.7
- DOI:
- 10.4238/2014.December.19.7
Effects of eplerenone on the activation of matrix metalloproteinase-2 stimulated by high glucose and interleukin-1�² in human cardiac fibroblasts
Authors: J.F. Chi, H. Uzui, H.Y. Guo, T. Ueda and J.D. Lee
The aim of this study was to determine the influence of high glucose (HG) and interleukin (IL)-1β on human cardiac fibroblast (HCF) functions, and to evaluate the effects of eplerenone in these responses. HCFs were cultured in normal or HG media in the absence or presence of IL-1β and/or eplerenone. We assessed matri.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.January.24.4
- DOI:
- 10.4238/2014.January.24.4
Development and characterization of polymorphic microsatellite loci in the sea cucumber Holothuria leucospilota
Authors: G. Dai, Z.B. Li, J.B. Shangguan, Y.F. Ning, H.W. Deng,Y. Yuan, Y.S. Huang, H. Yang and J. Lu
Holothuria leucospilota is a tropical holothurian species that is widely distributed in the tropical and sub-tropical India-Western Pacific Region. Eight polymorphic microsatellite loci were developed from H. leucospilota by using the protocol fast isolation by amplified fragment length polymorphism of sequences containing repeats and tested in 30 individ.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.8
- DOI:
- 10.4238/2015.January.26.8