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Effect of chronic hypoxia on penile erectile function in rats
Authors: D.P. Yu, X.H. Liu and A.Y. Wei
We examined the relationship between chronic hypoxia and erectile dysfunction in rat and its possible pathogenic mechanism. Forty-eight white male adult Sprague-Dawley rats were randomly divided into a test group and a control group. In accordance with the experimental time (2, 6, and 10 weeks), each group was divided into 3 subgroups, with 8 rats in each.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.9
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.9
Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population....
Authors: H.M. Wang, N.F. Li, J. Hong, L. Zhou and J.H. Chang
Genetic variation is thought to contribute to etiology of metabolic syndrome (MS). Neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L) is a candidate gene for MS. This study investigated the relationship between variations of NEDD4L and MS in the Kazakh, which is an ideal population to study the genetic mechanisms of complex.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.1
- DOI:
- 10.4238/2014.January.8.1
Industrial tomato lines: morphological properties and productivity
Authors: J.V.M. Peixoto, C. de M.S. Neto, L.F.C. Campos, W. de S. Dourado, A.P.O. Nogueira and A. dos R. Nascimento
The tomato is the second most produced vegetable in the world, with significant participation in the human diet. In addition, the production of tomatoes generates jobs and family income. The availability of improved cultivars that provide greater profitability to the producer and satisfactorily meets the needs of the fresh fru.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029540
- DOI:
- 10.4238/gmr16029540
Sample size for estimation of direct effects in path analysis of corn
Authors: M. Toebe, A. Cargnelutti Filho, L. Storck and A.D. L?ºcio
The objective of this study was to assess the sample size required for estimating the direct effects of explanatory variables on the grain yield of corn in the combinations formed by three types of hybrids x two harvests x nine scenarios of explanatory variables x two types of path analyses x four levels of accuracy. A total o.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029523
- DOI:
- 10.4238/gmr16029523
Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus
Authors: D.N. Fang, X.D. He, X.H. Li, H. Jia, P.Y. Li, Q. Lu, Z. Quan and Q.L. Wang
We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.3.1
- DOI:
- 10.4238/2014.January.3.1
Vegetative compatibility and parasexual segregation in Colletotrichum lindemuthianum, a fungal pathogen of the common bean
Authors: M.A.A. Castro-Prado, C.B. Querol, J.R. Santâ??Anna, C.T. Miyamoto, C.C.S. Franco, C.A. Mangolin, M.F.P.S. Machado
The heterokaryotic and vegetative diploid phases of Colletotrichum lindemuthianum are described using nutritional and biochemical markers. Nitrate non-utilizing mutants (nit), derived from R2047, R89, R73, R65, and R23 isolates, were paired in all possible combinations to obtain heterokaryons. Although pairings R2047/R89, R204.. Read More»
- Genet. Mol. Res. 6(3):
Homing of chloromethylbenzoyl ammonia-labeled bone marrow mesenchymal stem cells in an immune-mediated bone marrow failure mouse model in vivo.
Authors: Y. Xiao, Y. Wang, L. Li, Y.H. Li, Y. Pang, J.Y. Song and Z.J. Jiang
Aplastic anemia is an abnormal immune reaction disease in which T lymphocytes destroy hematopoietic stem and progenitor cells because of immune hyperactivity. Bone marrow mesenchymal stem cells (BMSCs) have hematopoietic supporting and immune regulation functions. This study investigated BMSCs homing in mice transplantation mo.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.3.2
- DOI:
- 10.4238/2014.January.3.2
A possible way that Ï?C31 integrase regulates the recombination direction
Authors: T.A. Liu, Y.X. Fang, H. Yin and Z.Z. Jing
φC31 integrase encoded by Streptomyces phage can mediate site-specific recombination between phage and host genomes. The recombination direction is generally considered to be accurately regulated, but the regulatory mechanisms involved are still unclear. Recently, some hyperactive mutants of φC31 integrase that can bypass the regulatory steps have.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.4
- DOI:
- 10.4238/2015.January.26.4
Apoptosis in different gastric lesions and gastric cancer: relationship with Helicobacter pylori, overexpression of p53 and aneuploidy
Authors: A.C. Targa, A.C.G. C?©sar, P.M. Cury, A.E. Silva
Apoptosis has an essential function in maintaining the integrity of the gastrointestinal mucosa. Its deregulation is associated with the occurrence of lesions such as in atrophic gastritis, peptic ulcers, intestinal metaplasia, and stomach tumorigenesis. Thus, the aim of the present study was to investigate the frequency of ap.. Read More»
- Genet. Mol. Res. 6(3):
Role of IL-10 and TNF-?± during Mycobacterium tuberculosis infection in murine alveolar macrophages
Authors: J. Shi, B.H. Sun, L.R. Zhou and X.S. Wang
Mycobacterium tuberculosis (Mtb) is known to be responsible for tuberculosis (TB), but the pathogenesis of this disease and the host defense mechanisms involved are, for the most part, poorly understood. In this study, we divided 30 male C57BL/6 mice into control and infection groups, and following injection with physiological saline or Mtb, respectively,.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037819
- DOI:
- 10.4238/gmr.15037819