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Combination of multiple gene markers to detect circulating tumor cells in the peripheral blood of patients with non-small cell lung cancer using real-time PCR
Authors: M. Ding, X. Li and T. Qiu
Our study aims to determine the clinical significance of human telomerase reverse transcriptase (hTERT), S-phase kinase-associated protein 2 (Skp2) and thyroid transcription factor-1 (TTF-1) mRNA expressions in peripheral blood (PB) of patients with non-small cell lung cancer (NSCLC). Real-time polymerase chain reaction was used to investigate the gene ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.24
- DOI:
- 10.4238/2015.October.21.24
Circulating B7-H4 in serum predicts prognosis in patients with hepatocellular carcinoma
Authors: S.A. Zhang, Z.X. Wu, X. Zhang, Z.Y. Zeng and D.L. Li
B7-H4 is member of the B7 family that negatively regulates the immune response, which are important for fine-tuning of the tumor microenvironment. Dysregulation of B7-H4 expression has been associated with tumor progression. However, expression level of B7-H4 in hepatocellular carcinoma (HCC) tissues is still a controversial topic. In addition, whether se.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.25
- DOI:
- 10.4238/2015.October.21.25
Characterization and expression analysis of somatic embryogenesis receptor-like kinase genes from Phalaenopsis.
Authors: Y.W. Huang, Y.J. Tsai and F.C. Chen
Somatic embryogenesis receptor-like kinase (SERK) genes have been found to be involved in the somatic embryogenesis of several plant species. We identified and characterized 5 PhSERK genes in the Phalaenopsis orchid. The amino acid sequences of PhSERKs and other SERK proteins are highly conserved, with the highest homology obs.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.18.11
- DOI:
- 10.4238/2014.December.18.11
Construction of a full-length cDNA library and preliminary analysis of expressed sequence tags from lymphocytes of half-pipe snowboarding athletes
Authors: Y.H. Zhao, Z.B. Zhang, C.Q. Zhao, Y. Zhang, Y.F. Wang, W.J. Guan and Z.Q. Zhu
The genes of top athletes are a valuable genetic resource for the human race, and could be exploited to identify novel genes related to sports ability, as well as other functions. We analyzed the expressed sequence tags from top half-pipe snowboarding athletes using the SMART complementary DNA (cDNA) library construction method to elucidate the characteri.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.13
- DOI:
- 10.4238/2015.October.21.13
Molecular characterization of twenty polymorphic microsatellite markers in the polyploid fruit tree species Syzygium samarangense (Myrtaceae)
Authors: J.M. Lai, C.C. Tsai, C.R. Yen, Y.Z. Ko, S.R. Chen, I.S. Weng, Y.S. Lin and Y.C. Chiang
Syzygium samarangense (Blume) Merr. & Perry (wax apple) is an important commercial fruit tree in Southeast Asia. Here, microsatellite markers were developed to evaluate genetic diversity and distinguish cultivars in this species. In total, 161 microsatellite loci with sufficient flanking sequences to design primer sets were isolated from wax apple usi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.22
- DOI:
- 10.4238/2015.October.21.22
Meiotic behavior of Brachiaria decumbens hybrids
Authors: V.F. Souza, M.S. Pagliarini, C.B. Valle, N.C.P. Bione, M.U. Menon and A.B. Mendes-Bonato
Brachiaria decumbens is a forage grass of inestimable value for livestock in Brazil due to its production of good quality forage even when planted on acid and poor soils, although it is susceptible to pasture spittlebugs. Only one cultivar, cv. Basilisk, has been used as the pollen donor in crosses with Brachiaria ruziziensis since 1988 at Embrapa Gado de.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.5
- DOI:
- 10.4238/2015.October.21.5
Serial analysis of gene expression in adenocarcinoma samples and normal colonic mucosa in a Chinese population
Authors: X.L. Zhang, F. Gao, W. Li, W.Z. Tang and S. Zhang
The goal of this study was to identify the differences in gene expression between adenocarcinoma samples and colonic normal mucosa of a Chinese population. Gene expression libraries of adenocarcinoma and normal colonic mucosa were generated by serial analysis of gene expression (SAGE). Expression tags were obtained from sequencing results using the SAGE20.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.11
- DOI:
- 10.4238/2015.October.21.11
Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population
Authors: J.Y. Li, F. Tao, X.X. Wu, Y.Z. Tan, L. He and H. Lu
Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were detec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.20
- DOI:
- 10.4238/2015.October.21.20
Cloning, molecular characterization, and expression analysis of a nucleoporin gene (rgNUP98-96) from Rehmannia glutinosa
Authors: Y.H. Yang and M.J. Li
Nucleoporin 98 (NUP98) and nucleoporin 96 (NUP96) are essential components of the nuclear pore complex (NPC) in eukaryote cells. However, there is a lack of available information about complete Rehmannia glutinosa NUP98-96 (rgNUP98-96) sequences. Here, the full-length cDNA sequence of rgNUP96-98 was isolated from R. glutinosa using rapid amplification of .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.23
- DOI:
- 10.4238/2015.October.21.23
Association of the GSTM1 null polymorphism with breast cancer in a Mexican population
Authors: O. Soto-Quintana, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez, R. RamÃ?Ârez-PatiÃ?±o, A. Ramos-Silva, L.E. Figuera, D.I. Carrillo-Moreno, I.A. GutiÃ?©rrez-Hurtado, A.M. Puebla-PÃ?©rez, B. SÃ?¡nchez-Llamas and M.P. Gallegos-Arreola
The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion inthe mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotyp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.2
- DOI:
- 10.4238/2015.October.26.2