Se
Development of SNP markers and their application for genetic diversity analysis in the oil palm (Elaeis guineensis)
Authors: P.W. Ong, I. Maizura, N.A.P. Abdullah, M.Y. Rafii, L.C.L. Ooi, E.T.L. Low and R. Singh
The genetic evaluation of oil palm germplasm collections is required for insight into the variability among populations. The information obtained is also useful for incorporating new genetic materials into current breeding programs. Single nucleotide polymorphisms (SNPs) have been widely used in many plant genetic studies due .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.9
- DOI:
- 10.4238/2015.October.9.9
DNA sequence variants in the carbonyl reductase 1 (cbr1) gene in seven breeds of Canis lupus familiaris
Authors: Q. Cheng, C. Sanborn, D. Ferguson and J.G. Blanco
The anticancer anthracyclines doxorubicin and daunorubicin are used to treat a variety of cancers in dogs. The therapeutic utility of anthracyclines is limited by cardiotoxicity in some cases. Synthesis of anthracycline alcohol metabolites by carbonyl reductase 1 (CBR1) is crucial for the pathogenesis of cardiotoxicity. We hyp.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.10
- DOI:
- 10.4238/2012.April.27.10
ZNF797 plays an oncogenic role in gastric cancer
Authors: D. Momenzadeh1, S. Rahman Zadeh1, M. Rezaei-Tavirani1, A. Baradaran-Rafii2, F. Ghasemvand1 and S. Heidari-Keshel1
Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, selfrenewal. A complex network of transcription factors and signaling molecules are required for continuation of this trait. ZNF797 (SALL4) is a zinc finger transcriptional activator crucial for maintenance of self-renewal in stem cells; howe.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.18
- DOI:
- 10.4238/2014.October.20.18
Differences in H3K4 trimethylation in in vivo and in vitro fertilization mouse preimplantation embryos
Authors: F.-R. Wu, Y. Liu, M.-B. Shang, X.-X. Yang, B. Ding, J.-G. Gao, R. Wang and W.-Y. Li
Trimethylation of lysine 4 at histone 3 (H3K4me3) is considered a marker of active transcription; it plays an important role in transcription reprogramming efficiency. We compared the levels of H3K4me3 in mouse preimplantation embryos from MII stage oocytes produced by in vivo and in vitro fertilization (IVF) using immunofluor.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.9
- DOI:
- 10.4238/2012.April.27.9
Single nucleotide polymorphisms of Ã?Â?6-desaturase and Elovl5 segments and their associations with common carp (Cyprinus carpio) growth traits
Authors: H. Ren, J. Yu, P. Xu and Y. Tang
Highly unsaturated fatty acids (HUFAs) are crucial for the nutritional health, physiology, and reproduction of vertebrates. The Δ6-desaturase and Elovl5 elongase genes produce essential enzymes in the biosynthetic pathway of HUFAs. Single nucleotide polymorphism (SNP) analysis of genes functionally related to the growth traits of the common carp (Cy.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.4
- DOI:
- 10.4238/2015.October.21.4
Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis
Authors: H.W. Fan, G.Y. Liu, C.F. Zhao, X.F. Li and X.Y. Yang
In this study, we investigated the differential expression profiles of cyclooxygenase-2 (COX-2) mRNA and proteins in osteoarthritis (OA) and rheumatoid arthritis (RA) patients to elucidate the role of COX-2 expression in the pathogenesis and development of these diseases and to provide novel drug targets for treating arthritis. A total of 60 patients who .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.7
- DOI:
- 10.4238/2015.October.21.7
Castor bean (Ricinus communis L.) as a potential environmental bioindicator
Authors: M.G. Mendes, C.D. Santos Junior, A.C.C. Dias and A.M. Bonetti
Biomonitoring of air quality using living organisms is a very interesting approach to environmental impact assessment. Organisms with a vast distribution, such as plants, are widely used for these purposes. The castor bean (Ricinus communis L.) is an oleaginous plant that can potentially be used as a bioindicator plant owing to its rapid growth and large .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.8
- DOI:
- 10.4238/2015.October.21.8
Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations
Authors: L. Xu, J. Lei, Q.Z. Wang, J. Li and L. Wu
Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangements and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been intensively studied. The objective of this study was to determine the clinicopathological characteristics in genotype-specific subsets of patients w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.18
- DOI:
- 10.4238/2015.October.21.18
Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis
Authors: R. Zeng, Q.P. Wang, M.X. Fang, J. Zhuang and R.X. Fan
The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.19
- DOI:
- 10.4238/2015.October.21.19
LITAF, DUSP1 and HHEX expression in mesenchymal stem cells from patients with psoriasis.
Authors: W.J. Chang, X.P. Niu, R.X. Hou, J.Q. Li, R.F. Liu, Q. Wang1, C.F. Wang,X.H. Li, G.H. Yin and K.M. Zhang
Psoriasis is a common chronic relapsing inflammatory skin disease, in which mesenchymal stem cells (MSCs) have been hypothesized to play an important role in abnormal localized inflammation and vascular proliferation observed in skin lesions. Previous studies have revealed abnormal gene expression patterns, DNA methylation sta.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.31
- DOI:
- 10.4238/2015.December.1.31