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Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology
Authors: Y.H. Ling, J.P. Ding, X.D. Zhang, L.J. Wang, Y.H. Zhang, Y.S. Li, Z.J. Zhang and X.R. Zhang
MicroRNAs (miRNAs) are an important class of small noncoding RNAs that are highly conserved in plants and animals. Many miRNAs are known to mediate a myriad of cell processes, including proliferation and differentiation, via the regulation of some transcription and signaling factors, which are closely related to muscle development and disease. In this stu.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.4
- DOI:
- 10.4238/2013.June.13.4
Potential hippocampal genes and pathways involved in Alzheimer�s disease:a bioinformatic analysis
Authors: L. Zhang, X.Q. Guo, J.F. Chu, X. Zhang, Z.R. Yan and Y.Z. Li
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in elderly people. Numerous studies have focused on the dysregulated genes in AD, but the pathogenesis is still unknown. In this study, we explored critical hippocampal genes and pathways that might potentially be involved in the pathogenesis of AD. Four t.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.15
- DOI:
- 10.4238/2015.June.29.15
Enzymatic differences between the endophyte Guignardia mangiferae (Botryosphaeriaceae) and the citrus pathogen G. citricarpa
Authors: A.S. Rom�£o, M.B. Sp�³sito, F.D. Andreote, J.L. Azevedo and W.L. Ara�ºjo
The endophyte Guignardia mangiferae is closely related to G. citricarpa, the causal agent of citrus black spot; for many years these species had been confused with each other. The development of molecular analytical methods has allowed differentiation of the pathogen G. citricarpa from the endophyte G. mangiferae, but the phys.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr952
- DOI:
- 10.4238/vol10-1gmr952
Vegetative compatibility and genetic analysis of Colletotrichum lindemuthianum isolates from Brazil
Authors: Q.L. Barcelos, E.A. Souza and K.J. Damasceno e Silva
The causal agent of common bean anthracnose, Colletotrichum lindemuthianum, has considerable genetic and pathogenic variability, which makes the development of resistant cultivars difficult. We examined variability within and between Brazilian pathotypes of C. lindemuthianum through the identification of vegetative compatibili.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr907
- DOI:
- 10.4238/vol10-1gmr907
Expression of recombinant human anti-TNF-�± scFv-Fc in Arabidopsis thaliana seeds
Authors: N. Yao, L. Ai, Y.Y. Dong, X.M. Liu, D.Z. Wang, N. Wang, X.W. Li,F.W. Wang, XK. Li, H.Y. Li and C. Jiang
Recombinant human anti-tumor necrosis factor (TNF)-α scFv-Fc was expressed in TKO mutant Arabidopsis thaliana seeds using plant-specific codons. Immunoblotting using a human IgG1 antibody detected the expression of anti-TNF-α proteins in plants. Results from qRT-PCR analysis demonstrated that the time of harvest si.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027726
- DOI:
- 10.4238/gmr.15027726
Polymorphisms of GSTM1, GSTT1, and p53 in Goi�¢nia, Goi�¡s
Authors: D.A. Rodrigues, I.R. Costa, J.V.M. Martins, K.S.F. e Silva and K.K.V.O. Moura
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested tha.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.4
- DOI:
- 10.4238/2015.December.21.4
Isolation of genomic DNA from defatted oil seed residue of rapeseed (Brassica napus)
Authors: M. Sadia, M.A. Rabban, S. Hameed, S.R. Pearce and S.A. Malik
A simple protocol for obtaining pure, restrictable and amplifiable megabase genomic DNA from oil-free seed residue of Brassica napus, an important oil seed plant, has been developed. Oil from the dry seeds was completely recovered in an organic solvent and quantified gravimetrically followed by processing of the residual bioma.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1009
- DOI:
- 10.4238/vol10-1gmr1009
Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease
Authors: A.F. Nascimento, J.S. Oliveira2, J.C. Silva Junior and A.A.L. Barbosa
The bs mutation is responsible for the most aggressive form of sickle cell disease, has a predominantly African origin, and arrived in Brazil through the slave trade. However, the Brazilian population is highly miscegenated, underscoring the importance of ancestry-informative markers (AIMs) for the identification of the geneti.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017604
- DOI:
- 10.4238/gmr.15017604
Critical genes in head and neck squamous cell carcinoma revealed by bioinformatic analysis of gene expression data
Authors: B. Wang, T. Wang, X.L. Cao and Y. Li
In this study, bioinformatic analysis of gene expression data of head and neck squamous cell carcinoma (HNSCC) was performed to identify critical genes. Gene expression data of HNSCC were downloaded from the Cancer Genome Atlas (TCGA) and differentially expressed genes were determined through significance analysis of microarrays. Protein-protein interacti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.10
- DOI:
- 10.4238/2015.December.21.10
Three novel SNPs of the bovine Tf gene in Chinese native cattle and their associations with milk production traits
Authors: Z.H. Ju, Q.L. Li, J.M. Huang, M.H. Hou, R.L. Li, J.B. Li, J.F. Zhong and C.F. Wang
Transferrin (Tf) is a β-globulin protein that transports iron ions in mammalian cells. It contributes to innate immunity to microbial pathogens, primarily by limiting microbial access to iron. Thus, polymorphisms present in bovine Tf could potentially underlie inherited differences in mastitis resistance and milk producti.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1038
- DOI:
- 10.4238/vol10-1gmr1038