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Influence of vascular endothelial growth factor and alpha-fetoprotein on hepatocellular carcinoma
Authors: E.Y. Yvamoto, R.F. Ferreira, V. Nogueira, M.A.S. Pinhel, G.D. Tenani, J.G.S.C. Andrade, M.E.L. Baitello, M.L. Greg�³rio, P.S. Fucuta, R.F. Silva, D.R.S. Souza and R.C.M.A. Silva
We evaluated the influence of the vascular endothelial growth factor (VEGF) -C936T polymorphism on prognosis of hepatocellular carcinoma (HCC), cirrhosis, and hepatitis C virus (HCV) infection. Serum VEGF and alpha-fetoprotein (AFP) levels were determined and used to characterize sensitivity and specificity. A total of 285 subjects were studied: 68 HCC, 1.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.16
- DOI:
- 10.4238/2015.December.21.16
Sequence variations in the FAD2 gene in seeded pumpkins
Authors: Y. Ge, Y. Chang, W.L. Xu, C.S. Cui and S.P. Qu
Seeded pumpkins are important economic crops; the seeds contain various unsaturated fatty acids, such as oleic acid and linoleic acid, which are crucial for human and animal nutrition. The fatty acid desaturase-2 (FAD2) gene encodes delta-12 desaturase, which converts oleic acid to linoleic acid. However, little is known about sequence variations in FAD2 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.19
- DOI:
- 10.4238/2015.December.21.19
Transcriptome analysis and de novo annotation of the critically endangered Amur sturgeon (Acipenser schrenckii)
Authors: X.J. Zhang, H.Y. Jiang, L.M. Li, L.H. Yuan and J.P. Chen
The aim of this study was to provide comprehensive insights into the genetic background of sturgeon by transcriptome study. We performed a de novo assembly of the Amur sturgeon Acipenser schrenckii transcriptome using Illumina Hiseq 2000 sequencing. A total of 148,817 non-redundant unigenes with base length of approximately 12.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027999
- DOI:
- 10.4238/gmr.15027999
Pathogenicity for onion and genetic diversity of isolates of the pathogenic fungus Colletotrichum gloeosporioides (Phyllachoraceae) from the State of Pernambuco, Brazil
Authors: M.X. Vila Nova, L.R. Borges, A.C.B. de Sousa, B.T.R.V. Brasileiro, E.A.L.A. Lima, A.F. da Costa and N.T. de Oliveira
Onion anthracnose, caused by Colletotrichum gloeosporioides, is one of the main diseases of onions in the State of Pernambuco. We examined the pathogenicity of 15 C. gloeosporioides strains and analyzed their genetic variability using RAPDs and internal transcribed spacers (ITS) of the rDNA region. Ten of the strains were obta.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1014
- DOI:
- 10.4238/vol10-1gmr1014
Quantitative assessment of protein function prediction programs
Authors: B.N. Rodrigues, M.B.R. Steffens, R.T. Raittz, I.C.R. Santos-Weiss and J.N. Marchaukoski
Fast prediction of protein function is essential for high-throughput sequencing analysis. Bioinformatic resources provide cheaper and faster techniques for function prediction and have helped to accelerate the process of protein sequence characterization. In this study, we assessed protein function prediction programs that accept amino acid sequences as i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.28
- DOI:
- 10.4238/2015.December.21.28
Silencing effect of lentiviral vectors encoding shRNA of Herp on endoplasmic reticulum stress and inflammatory responses in RAW 264.7 macrophages
Authors: F.L. Chen, Q. Li, J.Y. Zhang1,, L.J. Lei, Z. Zhang, T.N. Mahmoud, X.G. Wang, P.F. Lin, Y.P. Jin and A.H. Wang
Herp, a mammalian protein with a ubiquitin-like domain, can be strongly upregulated by endoplasmic reticulum (ER) stress during ER-associated protein degradation. However, the other cellular functions of Herp remain unclear. We explored the effect of Herp on ER stress and inflammatory responses in RAW 264.7 macrophages that had been exposed to tunicamycin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.31
- DOI:
- 10.4238/2015.December.21.31
Microbial diversity in Paris polyphylla var. yunnanensis rhizomes of varying ages
Authors: Y. Yang, S.C. Yang, J. Zhao, S. Udikeri and T. Liu
Endophyte microorganisms live inside plants without causing them any apparent damage. Recently, endophytic microorganisms have attracted attention because they can produce bioactive compounds of biotechnological interest. The endophytic microorganisms in Paris polyphylla var. yunnanensis (Liliaceae) - a species used since antiquity in traditional Chinese .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.34
- DOI:
- 10.4238/2015.December.21.34
Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations
Authors: P.Y. Chang, L. Qin, P. Zhao and Z.Y. Liu
Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases. In this study, we investigated the association between RGS5 gene variants and hypertension in the Mongolian and Han populations. Peripheral blood was obtained from 429 unrelated Mongolian herdsmen and 416 Han farmers [including essential hyperte.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.37
- DOI:
- 10.4238/2015.December.21.37
DNA and RNA polymerase activity in a Moniliophthora perniciosa mitochondrial plasmid and self-defense against oxidative stress
Authors: B.S. Andrade, C. Villela-Dias, D.S. Gomes, F. Micheli and A. G�³es-Neto
Moniliophthora perniciosa (Stahel) Aime and Phillips-Mora is a hemibiotrophic basidiomycete (Agaricales, Tricholomataceae) that causes witches’ broom disease in cocoa (Theobroma cacao L.). This pathogen carries a stable integrated invertron-type linear plasmid in its mitochondrial genome that encodes viral-like DNA and RNA polymerases related to fun.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.3
- DOI:
- 10.4238/2013.June.13.3
Genetic diversity of Vriesea cacuminis (Bromeliaceae): an endangered and endemic Brazilian species
Authors: P.C.C. Ribeiro, L.C. Pinheiro, R. Domingues, R.C. Forzza, M.A. Machado and L.F. Viccini
Data about the genetic structure can help to understand the evolutionary process of natural populations as well as to drive strategies of conservation. Vriesea cacuminis, an endemic Brazilian Bromeliad, has been found in 2 areas of Minas Gerais State. One is a legal preservation unit (Ibitipoca State Park) and the other an unprotected area (Serra Negra). .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.2
- DOI:
- 10.4238/2013.June.13.2