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Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2
Authors: N.I. Hanafi, A.S. Mohamed, J. Md Noor, N. Abdul Hamid Hasani, R. Siran, N.J. Osman, S. Ab Rahim and S.H. Sheikh Abdul Kadir
Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of S.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028150
- DOI:
- 10.4238/gmr.15028150
A systematic review of the intergenerational aspects and the diverse genetic profiles of Huntington�s disease
Authors: L.A. Agostinho, S.R. dos Santos, R.M.P. Alvarenga and C.L.A. Paiva
Huntington’s disease (HD) is a rare progressive and fatal neurogenetic degenerative disease, characterized by movement and personality disorders and by progressive dementia. Its prevalence varies by ethnic origin and different genetic profiles predisposing individuals to HD in each population. The prevalence of HD is 5-10 per 100,000 individuals in .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.6
- DOI:
- 10.4238/2013.June.13.6
Expression of glyceraldehyde 3-phosphate dehydrogenase is enhanced in Leishmania spp naturally resistant to nitric oxide
Authors: M.C. Rios, W.R.T. Silva, A.F. Azevedo, P.L. Santos, S.A. Teixeira, M.N. Muscar�¡, S.M. Thomazzi, R.P. Almeida, R.P.M. Fernandesand R. Scher
Leishmania spp are the causative agents of a spectrum of diseases termed leishmaniasis that affect mammals, including humans and dogs. Although reactive nitrogen species are employed in the control of parasitism by the immune system, it is known that Leishmania can withstand this oxidative stress. As the mechanism by which these species are resistant to n.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.4
- DOI:
- 10.4238/2015.June.29.4
Analysis of genetic diversity among Chinese wild Vitis species revealed with SSR and SRAP markers
Authors: Z.B. Jing, X.P. Wang and J.M. Cheng
The genetic diversity among 80 Vitis materials including 62 indigenous accessions of 17 wild Vitis species in China and 7 interspecific hybrids, 10 V. vinifera L. cultivars, and 1 V. riparia Michaux were evaluated by simple sequence repeat and sequence-related amplified polymorphism markers. A total of 10 simple sequence repeat primers and 11 sequence-rel.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.5
- DOI:
- 10.4238/2013.June.13.5
Impact of early enteral and parenteral nutrition on prealbumin and high-sensitivity C-reactive protein after gastric surgery
Authors: B. Li, H.-Y. Liu, S.-H. Guo, P. Sun, F.-M. Gong and B.-Q. Jia
We investigated the impact of early enteral nutrition (EEN) and parenteral nutrition (PN) on prealbumin (PA) and highsensitivity C-reactive protein (hs-CRP) in patients after gastric cancer surgery. Sixty-eight selected patients undergoing gastric cancer surgery were randomly divided into the EEN (N = 34) and PN (N = 34) groups. Body weight (BW), serum al.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.6
- DOI:
- 10.4238/2015.June.29.6
Bayesian GGE biplot models applied to maize multi-environments trials
Authors: L.A. de Oliveira, C.P. da Silva, J.J. Nuvunga, A.Q. da Silva and M. Balestre
The additive main effects and multiplicative interaction (AMMI) and the genotype main effects and genotype x environment interaction (GGE) models stand out among the linear-bilinear models used in genotype x environment interaction studies. Despite the advantages of their use to describe genotype x environment (AMMI) or genoty.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028612
- DOI:
- 10.4238/gmr.15028612
Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients
Authors: R. Nemati, J. Lu, V. Ramachandran, A. Etemad, M. Heidari, M.J. Yahya, R. Roozafzoon and P. Ismail
The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a comm.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026241
- DOI:
- 10.4238/gmr.15026241
Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice
Authors: S. Wei, Z. Gong, L. An, T. Zhang, H. Dai and S. Chen
This study investigated the effects of pregnant mare serum gonadotropin (PMSG) and cloprostenol (CLO) on estrus induction and synchronization, uterine development, and follicle-stimulating hormone receptor (FSHR) expression in mice. A total of 105 Kunming pre-puberty mice were divided into seven subgroups. Three PMSG subgroups were injected intraperitonea.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.12
- DOI:
- 10.4238/2015.June.29.12
Bayesian forecasting of temporal gene expression by using an auto regressive panel data approach
Authors: M. Nascimento, F.F. e Silva, T. S�¡fadi, A.C.C. Nascimento, L.M.A. Barroso, L.S. Gl�³ria and B. de S. Carvalho
We propose and evaluate a novel approach for forecasting gene expression over non-observed times in longitudinal trials under a Bayesian viewpoint. One of the aims is to cluster genes that share similar expression patterns over time and then use this similarity to predict relative expression at time points of interest. Express.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027299
- DOI:
- 10.4238/gmr.15027299
Differential gene expression in drought-tolerant sugarcane roots
Authors: J.S. Vantini, G.C. Dedemo, D.F. Jovino Gimenez, L.F.S. Fonseca, R.I.D. Tezza, M.A. Mutton, J.A. Ferro and M.I.T. Ferro
Drought is one of the most frequent abiotic stresses limiting the productivity and geographical distribution of sugarcane culture. The use of drought-tolerant genotypes is one approach for overcoming the effects of water stress. We conducted a comparative study to identify gene expression profiles under water stress in tolerant sugarcane roots. Two differ.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.13
- DOI:
- 10.4238/2015.June.29.13