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Effects of cisplatin and panobinostat on human mesothelial (Met-5A) and malignant pleural mesothelioma (MSTO-211H) cells
Authors: K.E. Gultekin1, M.K. Yurdakonar1, E. Yaman1, U.S. Yuce1, A. Yilmaz2, E. Alp3, A. Celik4, S.M. Demiroz4 and H.I. Onen2
New therapeutic approaches are still needed for effective malignant pleural mesothelioma treatment. The use of classical chemotherapy agents in combination with newly developed molecules may shed light on new therapeutic approaches. We aimed to determine the efficacy of panobinostat, alone and in combination with cisplatin, on cell survival and mRNA expre.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.11.2
- DOI:
- 10.4238/2013.November.11.2
â??Extended Fitnessâ? hypothesis: a link between individual and group selection
Authors: S.J. de Souza
What are the targets of natural selection remains a controversial issue in Biology. Here I propose the “Extended Fitness” hypothesis, in which extended phenotypes emerge as a link between individual and group selection. The basic premise of the extended fitness hypothesis is that extended phenotypes can be used by members of the same group sin.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.17.5
- DOI:
- 10.4238/2013.October.17.5
Analysis of protein-protein interaction network in chronic obstructive pulmonary disease
Authors: Y.P. Yuan, Y.H. Shi and W.C. Gu
Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality throughout the world. The purpose of our study was to uncover biomarkers and explore its pathogenic mechanisms at the molecular level. The gene expression profiles of COPD samples and normal controls were downloaded from Gene Expression Omnibus. Matlab was used for .. Read More»
- Genet. Mol. Res. 13(4):
Novel method to establish molecular identity using inter-simple sequence repeat markers in cotton (Gossypium hirsutum) cultivars
Authors: Z.-Y. Zhao, M.-X. Zhi, Z.-Y. Zhang, H.-L. Sun, Y.-S. Liu and X.-J. Li
Plant molecular identity (ID) is used to describe molecular characteristics of plants, which should contain all of the necessary information. Using inter-simple sequence repeat (ISSR) primers, molecular ID can be described in a way that reflects the polymerase chain reaction (PCR) conditions, annealing temperature, and the ban.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.5
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.5
Effects of glucose sensing/signaling on oxidative stress response in glucose repression mutants of Schizosaccharomyces pombe
Authors: B. Palabiyik, F. Jafari Ghods and E. Onay Ucar
The resistant to glucose repression mutants of Schizosaccharomyces pombe (ird5, ird13, and ird14) have a high tolerance to oxidative stress induced by H2O2. In all ird mutants, the increased expression level of the fbp1 gene can be interpreted as a lack of glucose repression in these mutants. To investigate the mechanisms of the oxidative stress response .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.25.3
- DOI:
- 10.4238/2013.October.25.3
Polymorphic microsatellite loci isolated from Cervus unicolor (Cervidae) show inbreeding in a domesticated population of Taiwan Sambar deer
Authors: D.Y. Lin, T.Y. Chiang, C.C. Huang, H.D. Lin, S.J. Tzeng, S.R. Kang, H.M. Sung and M.C. Wu
Primers for eight microsatellites were developed; they successfully amplified DNA from 20 domesticated Formosan Sambar deer (Cervus unicolor swinhoei). All loci were polymorphic, with 10-19 alleles per locus. The average observed heterozygosity across loci and samples was 0.310, ranging from 0 to 0.750 at each locus. All loci .. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.7
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.7
Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goi?¢nia Central-West Region of Brazil
Authors: C.T.X. Silva, N.B. Costa, K.S.F. Silva, R.E. Silva and K.K.V.O. Moura
In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polyme.. Read More»
- Genet. Mol. Res. 13(4):
A new reliable reference gene UBA52 for quantitative real-time polymerase chain reaction studies in pyloric cecal tissues of the starfish Asterias rubens
Authors: A.F. Sadritdinova, A.A. Dmitriev, A.V. Snezhkina, M.S. Belenikin, G.S. Krasnov, O.G. Manylov, A.A. Kudryavtsev, N.V. Melnikova, A.S. Speranskaya, M.V. Darii, V.A. Lakunina, L.A. Uroshlev, A.O. Smurov, O.A. Stepanov and A.V. Kudryavtseva
The starfish Asterias rubens is one of the most abundant echinoderm species in the White, Barents, North, and Baltic Seas.This species is an important component of marine ecosystems and a model object for certain biological studies, in particular those requiring quantitative estimation of gene expression. As a rule, expression.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.23.8
- DOI:
- http://dx.doi.org/10.4238/2014.May.23.8
Decreased expression of PIAS1 and PIAS3 in essential thrombocythemia patients
Authors: H.-H. Hsiao1,2, Y.-C. Liu1,2, M.-Y. Yang3, Y.-F. Tsai2, T.-C. Liu1,2, C.-S. Chang1,2 and S.-F. Lin1,2
Gain of function mutation of Janus kinase 2 (JAK2V617F) has been identified in Philadelphia-negative myeloproliferative diseases; about half of essential thrombocythemia (ET) patients harbor this mutation. The activated JAK-STAT pathway promotes cell proliferation, differentiation and anti-apoptosis. We studied the role of negative regulators of the JAK-S.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.10
- DOI:
- 10.4238/2013.November.18.10
Using PCR-RFLP for sexing of the endangered Gal?¡pagos petrel (Pterodroma phaeopygia)
Authors: L. Pati?±o, M. Cruz, P. Mart?nez and V. Cede?±o-Escobar
Pterodroma phaeopygia is a critically endangered avian species of the Galápagos Islands. This bird is sexually monomorphic, making it difficult to identify the sex. This information, however, is relevant to studies of behavior, ecology, and management of wild or captive populations. Here, we aimed to implement a molecular approach for determining s.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.13
- DOI:
- 10.4238/2013.October.18.13