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Prediction of genetic risk factors of atherosclerosis using various bioinformatic tools
Authors: H.X. Wang and Y.X. Zhao
The aim of this study was to identify potential markers of atherosclerosis development in familial hypercholesterolemia (FH) patients. GSE13985 microarray data, generated using blood samples from 5 FH patients and 5 matched controls, was downloaded from the Gene Expression Omnibus. Differentially expressed genes (DEGs) between.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027347
- DOI:
- 10.4238/gmr.15027347
Post-transcriptional silencing of the SGE1 gene induced by a dsRNA hairpin in Fusarium oxysporum f. sp cubense, the causal agent of Panama disease
Authors: J.S. Fernandes, P.C.S. Angelo, J.C. Cruz, J.M.M. Santos, N.R. Sousa and G.F. Silva
Fusarium oxysporum f. sp cubense (Foc), the causal agent of Panama disease, is responsible for economic losses in banana crops worldwide. The identification of genes that effectively act on pathogenicity and/or virulence may contribute to the development of different strategies for disease control and the production of resista.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027941
- DOI:
- 10.4238/gmr.15027941
Comparison of EGFR mutation rates in lung adenocarcinoma tissue and pleural effusion samples
Authors: Y. Guan, Z.J. Wang, L.Q. Wang, D.F. Hua and J. Liu
The goal of the current study was to investigate the differences in epidermal growth factor receptor (EGFR) mutation rates in tumor tissue and pleural effusion specimens from patients with lung adenocarcinoma. PCR amplification and gene sequencing were used to detect EGFR mutations in exons 18, 19, 20, and 21 in tumor tissue a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027001
- DOI:
- 10.4238/gmr.15027001
Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy
Authors: X. Li, C.Y. Liu, Y.S. Li, J. Xu, D.G. Li, X.I. Li and D. Han
Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027465
- DOI:
- 10.4238/gmr.15027465
Development and characterization of microsatellite loci in Brasenia schreberi (Cabombaceae) based on the next-generation sequencing
Authors: H. Liu, Z.C. Long, L.N. Li, Q.F. Wang, J.M. Chen and K. Liao
To understand genetic variability of the endangered aquatic herb Brasenia schreberi (Cabombaceae), we describe 31 microsatellite markers obtained using next-generation sequencing. A total of 24 individuals from the population of Jackson Lake, USA, were genotyped for each marker. Twenty-eight markers were polymorphic. The numbe.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027886
- DOI:
- 10.4238/gmr.15027886
Analysis of selected glutathione S-transferase gene polymorphisms in Malaysian type 2 diabetes mellitus patients with and without cardiovascular disease
Authors: A. Etemad, R. Vasudevan, A.F.A. Aziz, A.K.M Yusof, S. Khazaei, N. Fawzi, S. Jamalpour, M. Arkani, N.A. Mohammad and P. Ismail
Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025845
- DOI:
- 10.4238/gmr.15025845
Mitochondrial DNA COI characterization of Helicoverpa armigera (Lepidoptera: Noctuidae) from Paraguay and Uruguay
Authors: J.A. Arnemann, W.J. James, T.K. Walsh, J.V.C. Guedes, G. Smagghe, E. Castiglioni and W.T. Tay
Since its detection in Brazil in 2013, the Old World cotton bollworm Helicoverpa armigera has been reported in Argentina, Paraguay, and Bolivia. Here we present evidence extending the South American range of H. armigera to Uruguay, using polymerase chain reaction and sequencing of the partial mitochondrial DNA (mtDNA) cytochro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028292
- DOI:
- 10.4238/gmr.15028292
Variability of Colletotrichum spp in common bean
Authors: S.F. Mota, Q.L. Barcelos, M.A. Dias and E.A. Souza
The Colletotrichum genus presents large genetic variability, as demonstrated by the occurrence of several pathogenic races and phenotypic traits. The objective of this study was to characterize 22 strains of C. lindemuthianum and Colletotrichum spp recovered from anthracnose lesions and bean scab, and to verify the relationshi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027176
- DOI:
- 10.4238/gmr.15027176
Analysis of �±1 and �±2 globin genes among patients with hemoglobin Adana in Malaysia
Authors: T.Y. Lee, M.I. Lai, P. Ismail, V. Ramachandran, J.A.M.A. Tan, L.K. Teh,R. Othman, N.H. Hussein and E. George
Hemoglobin (Hb) Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp] is a non-deletional α-thalassemia variant found in Malaysia. An improvement in the molecular techniques in recent years has made identification of Hb Adana much easier. For this study, a total of 26 Hb Adana α-thalassemia intermedia and 10 Hb Adana trai.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027400
- DOI:
- 10.4238/gmr.15027400
Characterization of grass carp spleen transcriptome during GCRV infection
Authors: B.H. Xu, L. Zhong, Q.L. Liu, T.Y. Xiao, J.M. Su, K.J. Chen, H.Q. Wang, Y.J. Dai and J. Chen
The aim of the study was to investigate the grass carp hemorrhagic infection pathway and its key-related genes. Grass carp reovirus (GCRV) might cause hemorrhagic disease in grass carps. Healthy grass carp fingerlings (N = 60) were divided into control and infected groups. Fish in the control group were intraperitoneally (ip) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026650
- DOI:
- 10.4238/gmr.15026650