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High levels of glucose promote the activation of hepatic stellate cells via the p38-mitogen-activated protein kinase signal pathway
Authors: L.K. Wu, Y.C. Liu, G. Ma, L.L. Shi and X.M. He
The relationship between the p38-mitogen-activated protein kinase (p38-MAPK) signal pathway and high glucose-induced hepatic stellate cell (HSC) activation was investigated in this study. Sixty human HSC samples were randomly selected and used in the control (cultured normally), high-glucose (cultured in the presence of high g.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038419
- DOI:
- 10.4238/gmr.15038419
Administration of low-dose cyclosporine alone for the treatment of elderly patients with membranous nephropathy
Authors: M.X. Li, Y.W. Yu, Z.Y. Zhang, H.D. Zhao and F.L. Xiao
This study aimed to investigate the effects of administration of low-dose cyclosporine A (CsA) alone and the combination of low-dose CsA and a low-dose hormone for the treatment of elderly patients with membranous nephropathy. We divided 27 patients into two groups as follows: low-dose CsA group (group A) and the group receiving a combination of a low-dos.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.27
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.27
Activation of the ERK1/2 pathway by the CaMEK gene via adeno-associated virus serotype 9 in cardiomyocytes
Authors: Y.-N. Yang, W.-N. Ji1, Y.-T. Ma, X.-M. Li, B.-D. Chen, Y. Xiang and F. Liu
Extracellular signal-regulated kinase (ERK1/2) is one of the mitogen-activated protein kinases, key components of the reperfusion injury salvage kinase pathway, which plays an important role in protecting the myocardium from lethal ischemia-reperfusion injury. Constitutive activation of the mitogen-activated protein kinase kinase 1 (CaMEK) can promote ERK.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.17.1
- DOI:
- 10.4238/2012.October.17.1
IL-8 mRNA expression in the mouse mammary glands during pregnancy and lactation
Authors: H.P. Li, Y.J. Guo, H.S. Zhu, K. Zhong, G.M. Zha, L.F. Wang, Y.L. Wang, W.F. Lu, Y.Y. Wang and G.Y. Yang
Interkeukin-8 (IL-8) is an important inflammatory mediator. It is an angiogenic factor associated with inflammation and carcinogenesis. To date, research on IL-8 has been limited to its role as an indicator of inflammation. There has been no systematic research concerning IL-8 expression levels in the mouse mammary gland durin.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.9.10
- DOI:
- 10.4238/2012.October.9.10
Genetic diversity of central and peripheral populations of Toona ciliata var. pubescens, an endangered tree species endemic to China
Authors: J. Liu, J.M. Jiang and Y.T. Chen
Our objective was to examine the genetic diversity of central and peripheral populations of Toona ciliata var. pubescens, to elucidate whether the central-peripheral hypothesis applies to these populations. We analyzed 392 individuals from nine natural populations using eight pairs of polymorphic SSR primers. The results showe.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.17.10
- DOI:
- http://dx.doi.org/10.4238/2014.June.17.10
DNA barcoding reveals high levels of genetic diversity in the fishes of the Itapecuru Basin in Maranh�£o, Brazil
Authors: M.H.S. Nascimento, M.S. Almeida, M.N.S. Veira, D. Limeira Filho, R.C. Lima, M.C. Barros and E.C. Fraga
DNA barcoding is a useful complementary tool for use in traditional taxonomic studies due to its ability to detect cryptic species, and may be particularly efficient in the identification of fish species. The fish fauna of the Itapecuru River represents an important fishery resource in the Brazilian State of Maranhão, a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038476
- DOI:
- 10.4238/gmr.15038476
Molecular characterization and upregulation of cytosolic manganese superoxide dismutase by imidazole derivative KK-42 in Macrobrachium nipponense
Authors: W.F. Wang, L.M. Mu, X.S. Wu, H. Yang and Q.J. Ning
Imidazole derivative KK-42 is a well-known regulator of insect growth. KK-42 pretreatment has been shown to promote the survival of Macrobrachium nipponense infected with Aeromonas hydrophila, possibly via activation of superoxide dismutase (SOD). In this study, the cytMnSOD gene was cloned from the hepatopancreas of M. nippon.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038484
- DOI:
- 10.4238/gmr.15038484
Analysis of key genes and pathways involved in acute lung injury in a mouse model
Authors: Q.H. Han, N. Han, Y.Z. Liu, Q.H. Jin, Q.Y. Lu and Z.C. Li
A mouse model of acute lung injury (ALI) was chosen in this study to explore the key genes and pathways involved in the process of ALI with microarray technology. Gene expression microarray data were downloaded from the Gene Expression Omnibus database. Mice from the experimental group were further divided into 6 subgroups, wh.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.18.1
- DOI:
- http://dx.doi.org/10.4238/2014.June.18.1
Identifying differences in protein expression levels by spectral counting and feature selection
Authors: P.C. Carvalho, J. Hewel, V.C. Barbosa and J.R. Yates III
Spectral counting is a strategy to quantify relative protein concentrations in pre-digested protein mixtures analyzed by liquid chromatography online with tandem mass spectrometry. In the present study, we used combinations of normalization and statistical (feature selection) methods on spectral counting data to verify whether.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr426
- DOI:
- 10.4238/vol7-2gmr426
Identification and abundance of miRNA in chicken hypothalamus tissue determined by Solexa sequencing
Authors: G.R. Sun, M. Li, G.X. Li, Y.D. Tian, R.L. Han and X.T. Kang
We used Solexa sequencing technology to identify and determine the abundance of miRNAs and compared the characteristics and expression patterns of miRNA of 1-day-old and 36-week-old chicken hypothalamuses. We obtained 17,825,753 and 10,928,745 high-quality reads from 36-week-old and 1-day-old chickens, respectively. Three hund.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.2.2
- DOI:
- 10.4238/2012.October.2.2