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Tumor necrosis factor-�± and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients
Authors: R.M. de Albuquerque Maranh�£o, F.A. Martins Esteves, S. Crovella, L. Segat5 and P.R. Eleut�©rio Souza
The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibil.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.
- DOI:
- 10.4238/2015.
Normal and defective mariner-like elements in Rhynchosciara species (Sciaridae, Diptera)
Authors: P. Rezende-Teixeira, C. Lauand, F. Siviero and G.M. Machado-Santelli
Mariner-like elements are widely present in diverse organisms. These elements constitute a large fraction of the eukaryotic genome; they transpose by a “cut-and-paste” mechanism with their own transposase protein. We found two groups of mobile elements in the genus Rhynchosciara. PCR using primers designed from R. .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr796
- DOI:
- 10.4238/vol9-2gmr796
Effect of rosuvastatin on high glucose-induced endoplasmic reticulum stress in human umbilical vein endothelial cells
Authors: J.Z. Xu, Y.L. Chai and Y.L. Zhang
It is well established that endothelial injury plays an essential role in atherosclerotic plaque formation. Accumulating evidence has shown that high glucose levels may detrimentally affect cultured endothelial cells through endoplasmic reticulum (ER) stress. In this study, we investigated the effect of rosuvastatin on high gl.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048935
- DOI:
- 10.4238/gmr15048935
Transferability of microsatellite markers of Capsicum annuum L. to C. frutescens L. and C. chinense Jacq.
Authors: S.I.C. Carvalho, C.F. Ragassi, I.B. Oliveira, Z.P.S. Amaral, F.J.B. Reifschneider, F.G. Faleiro and G.S.C. Buso
In order to support further genetic, diversity, and phylogeny studies of Capsicum species, the transferability of a Capsicum annuum L. simple sequence repeat (SSR) microsatellite set was analyzed for C. frutescens L. (“malagueta” and “tabasco” peppers) and C. chinense Jacq. (smell peppers, among other types). A total of 185 SSR pri.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.1
- DOI:
- 10.4238/2015.July.17.1
Expression of �²-defensins in intestines of chickens injected with vitamin D3 and lipopolysaccharide
Authors: L. Lu, S.M. Li, L. Zhang, X.Q. Liu, D.Y. Li, X.L. Zhao and Y.P. Liu
The objective of this study was to evaluate the effect of vitamin D3 (VD3) on the regulation of chicken intestinal b-defensin genes under normal and lipopolysaccharides (LPS) conditions. Four treatment groups were used, including a negative control group, VD3-injection group, LPS-injection group, and both VD3-injection and LPS-injection group. At 4, 24, a.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.12
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.12
In silico analysis of gene content in tomato genomic regions mapped to the Ty-2 resistance gene
Authors: Y.F. Liu, H.J. Wan, Y.P. Wei, R.Q. Wang, M.Y. Ruan, Q.J. Ye, Z.M. Li, G.Z. Zhou, Z.P. Yao and Y.J. Yang
Tomato yellow leaf curl virus is one of the main diseases affecting tomato production worldwide. Previous studies have shown that Ty-2 is an important resistance gene located between molecular markers C2_At2g28250 (82.3 cM) and T0302 (89.0 cM), and exhibits strong resistance to tomato yellow leaf curl virus in Asia. In this study, Ty-2 candidate genes wer.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.2
- DOI:
- 10.4238/2015.July.17.2
Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
Authors: K. Yu, Y. Ji, H. Wang, Q.K. Xuan, B.B. Li, J.J. Xiao, W. Sun and X.Q. Kong
We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048929
- DOI:
- 10.4238/gmr15048929
Mining SNPs from EST sequences using filters and ensemble classifiers
Authors: J. Wang, Q. Zou and M.Z. Guo
Abundant single nucleotide polymorphisms (SNPs) provide the most complete information for genome-wide association studies. However, due to the bottleneck of manual discovery of putative SNPs and the inaccessibility of the original sequencing reads, it is essential to develop a more efficient and accurate computational method f.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr765
- DOI:
- 10.4238/vol9-2gmr765
Serious pulmonary infection in a splenectomized patient with adult type 1 Gaucher disease
Authors: Y. Zhang, Y.F. Mao and J.M. Du
A 49-year-old man with a history of Gaucher disease type 1, resulting in serious splenomegaly and eating disorder, was referred to our department and underwent a splenectomy under general anesthesia. Gaucher disease is very rare, and its first signs are unexplained splenomegaly and hypersplenism. On preoperative examination, the patient’s platelet c.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.13
Complete chloroplast genome sequence of cultivated Morus L. species
Authors: Q.L. Li, J.Z. Guo, N. Yan and C.C. Li
The complete chloroplast genome (cpDNA) sequences of two cultivated species of Morus L. (Morus atropurpurea and Morus multicaulis) are reported and reconstructed in this study, and were compared with that of wild Morus mongolica. In M. atropurpurea, the circular genome is 159,113 bp in size and comprises two identical inverted.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048906
- DOI:
- 10.4238/gmr15048906