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Study of the radiotherapy sensitization effects and mechanism of capecitabine (Xeloda) against non-small-cell lung cancer cell line A549
Authors: J.J. Zhu, J.J. Shan, L.B. Sun1 and W.S. Qiu
The purpose of this study was to explore the radiotherapy sensitization effects and the mechanism of capecitabine (Xeloda) against the non-small-cell lung cancer cell line, A549. γ-[60Co] radiation was used as the intervention method. Proliferative inhibition of capecitabine on A549 cells was determined by the CCK-8 method. The effects of capecitabi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Meta-analysis of differentially expressed genes in autism based on gene expression data
Authors: L.F. Ning, Y.Q. Yu, E.T. GuoJi, C.G. Kou, Y.H. Wu, J.P. Shi,L.Z. Ai and Q. Yu
The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in autism. We performed a meta-analysis using new publicly available Gene Expression Omnibus (GEO) datasets of autism. We performed Gene Ontology (GO) enrichment analyses and pathway analysis using the Kyoto Enc.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.1
- DOI:
- 10.4238/2015.March.27.1
Molecular cloning and characterization of a subtilisin-like protease from Arabidopsis thaliana
Authors: D.H. Li, H. Xi, X.B. Yu and Y.P. Cai
The Arabidopsis thaliana genome encodes 56 subtilisin-like serine proteases (subtilases). In order to evaluate the protease activity of a previously uncharacterized subtilase, designated as AtSBT1.9, we cloned its full-length cDNA from A. thaliana seedlings. An AtSBT1.9 mature peptide coding sequence was inserted into the bacterial expression vector, pMAL.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Cloning and expression analysis of terpenoid metabolism-related gene NsyCMS in Nicotiana sylvestris
Authors: J. Lv, G.S. Liu, W. Li, Z. Hussian and Y.H. Sun
Terpenoids constitute the main class of secondary metabolites produced in plants with industrial, pharmacological, and agricultural interests. Nicotiana sylvestris has been widely adopted as a diploid model system in plant biology for studies of terpenoid biosynthesis. In this paper, we report the isolation and analysis of the 2-C-methyl-d-erythritol 2,4-.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.9
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.9
Selection of common bean genotypes for the Cerrado/Pantanal ecotone via mixed models and multivariate analysis
Authors: A.M. Corr�ªa, M.I.S. Moraes, H.K.A. de Abreu, T. Sharon, C.L.P. de Melo, M.A. Ito, P.E. Teodoro and L.L. Bhering
The common bean, Phaseolus vulgaris, is predominantly grown on small farms and lacks accurate genotype recommendations for specific micro-regions in Brazil. This contributes to a low national average yield. The aim of this study was to use the methods of the harmonic mean of the relative performance of genetic values (HMRPGV) .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048888
- DOI:
- 10.4238/gmr15048888
Expression and significance of SATB1 in the development of breast cancer
Authors: S. Zhang, X. Gao, Y. Ma, J. Jiang, Z. Dai, X. Yin, W. Min, W. Hui and B. Wang
Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer. However, its expression in different stages of breast cancer development have not been examined. We explored the role of SATB1 in the development of breast cancer by detecting SATB1 expression levels in di.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.10
Expression of acid phosphatase in the seminiferous epithelium of vertebrates
Authors: R.L. Peruquetti, S.R. Taboga and M.T.V. Azeredo-Oliveira
Acid phosphatases (AcPs) are known to provide phosphate to tissues that have high energy requirements, especially during development, growth and maturation. During spermatogenesis AcP activity is manifested in heterophagous lysosomes of Sertoli cells. This phagocytic function appears to be hormone-independent. We examined the .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr730
- DOI:
- 10.4238/vol9-2gmr730
Chromosome 7 translocation breakpoints in male carriers: clinical features and implications for genetic counseling
Authors: R.X. Wang, H.G. Zhang, Y. Pan, J.H. Zhu, F.G. Yue, L.T. Xue and R.Z. Liu
Balanced reciprocal translocations are associated with reproductive failure. Some reciprocal translocation carriers exhibit azoospermia or oligozoospermia, and an association exists between these chromosomal abnormalities and recurrent abortion. Previous reports have indicated the involvement of chromosome 7 translocations in .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048948
- DOI:
- 10.4238/gmr15048948
Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle
Authors: Y.X. Liu, X. Zhou, D.Q. Li, Q.W. Cui and G.L. Wang
Heat stress produces oxidative stress and affects the alternation of plasma K+ and Na+. Since Na+,K+-ATPase is sensitive to oxidative stress and critical for maintaining the homeostasis of these two ions, we examined the genetic polymorphism of the ATP1A1 gene in 160 Holstein cows using polymerase chain reaction low ionic stre.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr769
- DOI:
- 10.4238/vol9-2gmr769
Tumor necrosis factor-�± and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients
Authors: R.M. de Albuquerque Maranh�£o, F.A. Martins Esteves, S. Crovella, L. Segat5 and P.R. Eleut�©rio Souza
The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibil.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.
- DOI:
- 10.4238/2015.