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Genotoxicity and mutagenicity of Rosmarinus officinalis (Labiatae) essential oil in mammalian cells in vivo
Authors: E.L. Maistro, S.F. Mota, E.B. Lima, B.M. Bernardes and F.C. Goulart
Rosmarinus officinalis (rosemary) oil is widely used by the cosmetic, food, and pharmaceutical industries as a fragrance component of soaps, creams, lotions, and perfumes. Although it is popular, potential harmful side-effects of the oil have been described. We investigated the genotoxic and mutagenic potential of essential oi.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr857
- DOI:
- 10.4238/vol9-4gmr857
Transposable elements in Phyllostachys pubescens (Poaceae) genome survey sequences and the full-length cDNA sequences, and their association with simple-sequence repeats
Authors: M.B. Zhou, X.M. Liu, and D.Q. Tang
Phyllostachys pubescens is a woody bamboo with the highest ecological, economic, and cultural values of all bamboos in Asia. There is more genomic data available for P. pubescens than for any other bamboo species, including 2.12-Mb genome survey sequences (GSS) and 11.4-Mb full-length cDNA sequences (FL-cDNAs) currently deposi.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.6.3
- DOI:
- 10.4238/2011.December.6.3
Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules
Authors: A.A.S. Reis, D.M. Silva, M.P. Curado and A.D. da Cruz
Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individ.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr807
- DOI:
- 10.4238/vol9-4gmr807
Clinical applications of internal heat source analysis for breast cancer identification
Authors: F. Han, C.W. Liang, G.L. Shi, L. Wang and K.Y. Li
Nondestructive preoperative breast imaging techniques are widely used for breast cancer testing and diagnosis. This study aimed to evaluate the feasibility and efficacy of quantitative diagnosis via the thermal analysis of abnormal metabolism. Nine hundred forty-eight women who underwent breast biopsy from 2009 to 2013 were investigated. Thermal analysis .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.24
- DOI:
- 10.4238/2015.February.13.24
Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease
Authors: J.Y. Zhong, X.W. Zheng, H.D. Ye, H.B. Cui, W.P. Du, Z.X. Zhang, X.H. Fei, S.Y. Lin, J. Wang, J. Su, X.M. Chen and S.W. Duan
APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.8
- DOI:
- 10.4238/2015.October.2.8
Biosom: gene synonym analysis by self-organizing map
Authors: K.R. Otemaier, M.B.R. Steffens, R.T. Raittz, A. Brawerman and J.N. Marchaukoski
There are several guidelines for gene nomenclature, but they are not always applied to the names of newly identified genes. The lack of standardization in naming genes generates inconsistent databases with errors such as genes with the same function and different names, genes with different functions and the same name, and use of an abbreviated name. This.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.20.1
- DOI:
- 10.4238/2015.February.20.1
Relationship between polymorphisms in the proline dehydrogenase gene and schizophrenia risk
Authors: F. Ghasemvand, E. Omidinia, Z. Salehi and S. Rahmanzadeh
Previous studies have suggested that an association exists between the proline dehydrogenase gene (PRODH) and increased schizophrenia risk. We examined the prevalence of the PRODH 757C/T (Arg185Trp), 1766A/G (Gly521Arg), and 1852G/A (intronic mutation) polymorphisms in 175 patients with schizophrenia and 185 control subjects. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.14
- DOI:
- 10.4238/2015.October.2.14
Screening of crucial long non-coding RNAs in oral epithelial dysplasia by serial analysis of gene expression
Authors: X. Han, Y.B. Wei, G. Tian, Z. Tang, J.Y. Gao and X.G. Xu
Oral epithelial dysplasia (OED) is a premalignant lesion of the oral mucosa. Considering the poor 5-year survival rate of oral cancer, further investigation is needed in order to determine the pathogenesis of OED. In the present study, serial analysis of gene expression (SAGE) data from patients with OED were compared to norma.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.2.6
- DOI:
- 10.4238/2015.October.2.6
Characterization of chloroplast region rrn16-rrn23S from the tropical timber tree Cedrela odorata L. and de novo construction of a transplastomic expression vector suitable for Meliaceae trees and other economically important crops
Authors: L.A. LÃ?³pez-Ochoa, M.M. Apolinar-HernÃ?¡ndez and Y.J. PeÃ?±a-RamÃ?Ârez
The forest tree Spanish cedar (Cedrela odorata L.) is well-known for its high-value timber; however, this species is attacked by the shoot borer (Hypsipyla grandella) during its early years of development, resulting in branched stems and making the plants useless for high-quality wood production. The generation of resistant varieties expressing entomotoxi.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.20.2
- DOI:
- 10.4238/2015.February.20.2
Establishment of a rabbit model of coronary artery bypass graft and endothelial nitric oxide synthase gene transfection
Authors: Y. Zhu, H.-S. Wang, X.-M. Li and Z.-W. Wang
This study established an animal model of coronary artery bypass graft (CABG) surgery. The human endothelial nitric oxide synthase (eNOS) gene was transfected into grafted arterial walls to verify transfection efficiency. Forty rabbits were randomized into the following 4 equal groups: 1) eNOS gene transfection group (eNOS group); 2) empty eNOS gene trans.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.20.3
- DOI:
- 10.4238/2015.February.20.3