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Establishment of a neuroblastoma mouse model by subcutaneous xenograft transplantation and its use to study metastatic neuroblastoma
Authors: Q. Gao, C.F. Chen, Q. Dong, L. Hou, X. Chen, Y.L. Zhi, X. Li, H.T. Lu and H.Y. Zhang
The aim of this study was to establish a metastatic human neuroblastoma (NB) mouse model by xenograft in order to study the metastatic mechanisms of NB. A human NB cell line was obtained from a 5-year-old patient and cultured in vitro. A suspension of these cells was subcutaneously inoculated into nude mice at the right flank next to the forelimb. The bio.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer
Authors: Y. Dong, J.W. Liu, Y.J. Gao, T. Zhou and Y.M. Chen
We examined the relationships between singlenucleotide polymorphisms (SNPs) in the DNA repair gene XPD751 and the efficacy and time to disease progression (TTP) in colorectal cancer patients after platinum-based chemotherapy. Ninety-eight patients diagnosed with advanced colorectal cancer were subjected to oxaliplatin and 5-fluorouracil combination therap.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.8
- DOI:
- 10.4238/2015.May.22.8
Effects of docetaxel plus three-dimensional conformal radiation therapy on microvessel density and apoptosis expression in local advanced squamous non-small-cell lung cancer
Authors: X.J. Zhai, H.R. Cheng, H.L. Long, W.K. Mao, L. Cao, B.R. Xiao and R.Q. Li
We examined the effects of weekly single-agent docetaxel plus three-dimensional conformal radiation therapy (3D-CRT) on apoptotic index (AI) and microvessel density (MVD) in local advanced non-small-cell lung squamous cancer patients and analyzed the correlation of MVD, AI, and 50% tumor shrinkage time (T0.5) The molecular mechanism of docetaxel radiosens.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.9
- DOI:
- 10.4238/2015.May.22.9
Random amplified polymorphic DNA analysis of salt-tolerant tobacco mutants generated by gamma radiation
Authors: Ã?Â?. Ã?Â?elik and Ã?Â?. Atak
Salinity is one of the major problems limiting the yield of agricultural products. Radiation mutagenesis is used to improve salt-tolerant mutant plants. In this study, we aimed to improve salt-tolerant mutants of two oriental tobacco varieties. One thousand seeds of each variety (M0) were irradiated with 100, 200, 300, and 400 Gy gamma rays by Cs-137 gamm.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.12
- DOI:
- 10.4238/2015.February.13.12
Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment
Authors: M. Luo, X.H. Zhou, T. Zou, K. Keyim and L.M. Dong
We investigated type II deiodinase (DIO2 ) polymorphisms and serum thyroid hormone levels in subjects with mild cognitive impairment (MCI) in a Uygur population. We studied the DIO2 Thr92Ala (rs225014) and ORFa-Gly3Asp (rs12885300) polymorphisms of 129 unrelated MCI cases and 131 matched controls. All subjects were genotyped using SNaPshot SNP genotyping.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.10
- DOI:
- 10.4238/2015.May.22.10
Genetic analysis of seed-shattering genes in rice using an F3:4 population derived from an Oryza sativa x Oryza rufipogon cross
Authors: S.-J. Kwon, J. Yu, Y.J. Park, J.-H. Son, N.-S. Kim and J.K. Lee
Seed shattering of wild plant species is thought to be an adaptive trait to facilitate seed dispersal. For rice breeding, seed shattering is an important trait for improving breeding strategies, particularly when developing lines use interspecific hybrids and introgression of genes from wild species. We developed F3:4 recombinant inbred lines from an.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.14
- DOI:
- 10.4238/2015.February.13.14
De novo assembly and characterization of skin transcriptome using RNAseq in sheep (Ovis aries)
Authors: Y.J. Yue, J.B. Liu, M. Yang, J.L. Han, T.T. Guo, J. Guo, R.L. Feng and B.H. Yang
Wool is produced via synthetic processes of wool follicles, which are embedded in the skin of sheep. The development of new-generation sequencing and RNA sequencing provides new approaches that may elucidate the molecular regulation mechanism of wool follicle development and facilitate enhanced selection for wool traits through gene-assisted selection or .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.16
- DOI:
- 10.4238/2015.February.13.16
Analysis of the genetic effects of CAPN1 gene polymorphisms on chicken meat tenderness
Authors: J.T. Shu, M. Zhang, Y.J. Shan, W.J. Xu, K.W. Chen and H.F. Li
The micromolar calcium-activated neutral protease gene (CAPN1) is a physiological candidate gene for meat tenderness. Four previously identified single nucleotide polymorphism (SNP) markers located within the CAPN1 gene were evaluated for their associations with variation in the meat tenderness of a Chinese indigenous chicken breed, a higher meat quality .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.13.18
- DOI:
- 10.4238/2015.February.13.18
Lack of association between a common polymorphism of the endothelial lipasegene and early-onset coronary artery disease in a Chinese Han population
Authors: G.J. Cai, G.P. He, Z.Y. Huang, and C.P. Qi
A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.20.7
- DOI:
- 10.4238/2014.February.20.7
Development of two multiplex mini-sequencing panels of ancestry informative SNPs for studies in Latin Americans: an application to populations of the State of Minas Gerais (Brazil)
Authors: M.C.F. Silva*, L.W. Zuccherato*, G.B. Soares-Souza, Z.M. Vieira, L. Cabrera, P. Herrera, J. Balqui, C. Romero, H. Jahuira, R.H. Gilman, M.L. Martins and E. Tarazona-Santos
Admixture occurs when individuals from parental populations that have been isolated for hundreds of generations form a new hybrid population. Currently, interest in measuring biogeographic ancestry has spread from anthropology to forensic sciences, direct-to-consumers personal genomics, and civil rights issues of minorities, a.. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr911
- DOI:
- 10.4238/vol9-4gmr911