Polymorphism
Prevalence of variants that confer risk for venous thromboembolism in an elderly population of northeastern Brazil
Authors: H. Ferreira-Fernandes, P.N. Costa, H.F. Fernandes, A.P. Ara�ºjo-Neto, F.J. Motta, R. Canalle, F.K. Yoshioka, J.F. Guerreiro, R.R. Burbano, J.A. Rey and G.R. Pinto
Venous thromboembolism (VTE) is an important cause of morbidity and mortality stemming from cardiovascular disease. It is a multifactorial disease caused by a combination of acquired risk factors, of which advanced age is the most significant, and genetic factors, including the variants FV G1691A, FII G20210A, and MTHFR C677T. We estimated the prevalence .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.Mach.11.5
- DOI:
- 10.4238/2013.Mach.11.5
Genetic polymorphisms of the TLR4 gene and their association with susceptibility to type 2 diabetes mellitus in the Chinese population
Authors: X.D. Fu, X.Q. Sun, H.Y. Wang, J.F. Guo, G.Z. Zhang and Q.H. Xu
Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.13
- DOI:
- 10.4238/2013.September.19.13
Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations
Authors: F.R. Shen , C.Y. Yan, M. Liu, Y.H. Feng and Y.G. Chen
Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were inv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.12
- DOI:
- 10.4238/2013.September.19.12
Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk
Authors: R. Zhu, L.Q. Bi, H. Kong, S.L. Tilley, H. Wang and W.P. Xie
Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-convertin.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.8
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.8
Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility
Authors: S.E. Aydos, A. Karada��, T. ��zkan, B. Alt�±nok, M. Bunsuz, S. Heidargholizadeh, K. Aydos and A. Sunguro��lu
Infertility affects 1 in 6 couples and approximately 1 in 25 men. Male factor infertility is a major cause of spermatogenic anomalies, the causes of which are largely unknown. Impaired reproductive functions in men might result from physiological, genetic, and/or environmental factors such as xenobiotics. The multi-drug resistance1 (MDR1) gene encodes a P.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.8
- DOI:
- 10.4238/2015.June.11.8
Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population
Authors: H.D. Ye, Y.R. Li, Q.X. Hong, A.N. Zhou, Q.L. Zhao, L.M. Xu, M.Q. Xu, X.T. Xu, L.L. Tang, D.J. Dai, D.J. Jiang, Y. Huang,D.W. Wang and S.W. Duan
PPARD encodes peroxisome proliferator-activated receptor delta, which has been shown to play an important role in controlling lipid metabolism and atherosclerosis. In this case-control study, we explored the relationship between PPARD rs2016520 polymorphism and coronary heart disease (CHD) in a Han Chinese population. A total of 657 CHD cases and 640 cont.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.10
- DOI:
- 10.4238/2015.June.11.10
Polymorphisms in the nuclear factor kappa B gene association with recurrent embryo implantation failure
Authors: L. Luo, D.H. Li, X.P. Li, S.C. Zhang, C.F. Yan, J.F. Wu, Y.H. Qi and J. Zhao
Despite more than a century of intensive study, the mechanisms of successful pregnancy remain unclear. Recent research suggests that NF-κB (nuclear factor kappa B) plays an important role in embryo implantation. In the current study, we aimed to identify SNPs that contribute to genetic susceptibility for recurrent implan.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027759
- DOI:
- 10.4238/gmr.15027759
DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis
Authors: C.H. Liu,T. Tao1,L. Jiang1,B. Xu,L. Zhang, K. Lu,X.W. Zhang,S.Q. Chen,D.C. Liu and M. Chen
Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of va.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.14
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.14
Novel polymorphisms of the PRKAG2 gene and their association with body measurement and meat quality traits in Qinchuan cattle
Authors: C.Z. Fu,W.Q. Tian,Y.K. Li,S.J. Wei,G. Cheng,H.B. Wang and L.S. Zan
Body measurement and meat quality traits play important roles in the evaluation of productivity and economy in cattle, which are influenced by genes and environmental factors. PRKAG2, which encodes the γ2 regulatory subunit of AMPK, is associated with key metabolic pathways in muscle. We detected bovine PRKAG2 gene polymorphisms and analyzed their a.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.16
Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population
Authors: K. Liang, S.R. Dong and H. Peng
We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027933
- DOI:
- 10.4238/gmr.15027933