Polymorphism
Morphological and sequence-related amplified polymorphism-based molecular diversity of local and exotic wheat genotypes
Authors: S.M. Abdelkhalik, A.K.M. Salem, A.R. Abdelaziz, M.H. Ammar
Assessing genetic diversity is a prerequisite for the genetic improvement of wheat. Molecular markers offer accurate and reproducible means for assessing genetic diversity. Field performance and sequence-related amplified polymorphism (SRAP)-based assessment of molecular diversity was carried out on a set of 10 local and intro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027484
- DOI:
- 10.4238/gmr.15027484
Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case-control study in Rio de Janeiro
Authors: P. Coutinho, V. Sandim, J.A. Oliveira, G. Alves and A. Hatagima
The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr753
- DOI:
- 10.4238/vol9-1gmr753
Genetic relationships between Lolium (Poaceae) species revealed by RAPD markers
Authors: X. Ma, X.-Y. Gu, T.-T. Chen, S.-Y. Chen, L.-K. Huang and X.-Q. Zhang
The genus Lolium is one of the most important groupings of temperate forage grasses, including about eight recognized species that are native to some temperate and subtropical regions of the northern hemisphere. We examined genetic relationships among 18 accessions representing all Lolium species using RAPD markers. Among 50 random primers that we screene.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.4
- DOI:
- 10.4238/2013.March.11.4
Reply to commentary by G. Sikri and S. Dua on the article â??Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edemaâ? published in Genetics and Molecular Research 14 (3): 11562-11572 to the letter published in Genet. Mol. Res. 14 (4): 15904-15905
Authors: L.J. Wu
The object in this study was a Han Chinese population in Lhasa, with 3658 m in altitude from Chengdu, which has 505 m in altitude by air. Within 24 to 48 h before the subjects arrived in the plateau, they completed a basic situation questionnaire, under the guidance of medical staff. Within 24 to 48 h after they reached the plateau, the subjects completed.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016155
- DOI:
- 10.4238/gmr.15016155
Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population
Authors: M.Y. Yu, P.Q. Zhao, X.H. Yan, B. Liu, Q.Q. Zhang, R. Wang, C.H. Ma, X.H. Liang, F.L. Zhu and L.F. Gao
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recent.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.10.2
- DOI:
- 10.4238/2013.September.10.2
Roles of functional NFKB1 and ?²-TrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility
Authors: Z.H. Huo, H.J. Zhong, Y.S. Zhu, B. Xing and H. Tang
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.6
- DOI:
- 10.4238/2013.March.11.6
Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study
Authors: E.S. AlSuhaibani, N.A. Kizilbash, S. Malik, J.I. Dasti, F. Al Beladi and N. El-Morshedi
Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017360
- DOI:
- 10.4238/gmr.15017360
Association of APOA1 and APOA5 polymorphisms and haplotypes with lipid parameters in a Brazilian elderly cohort
Authors: T.K. Furuya, E.S. Chen, V.K. Ota, D.R. Mazzotti, L.R. Ramos, M.S. Cendoroglo, L.Q. Araujo, R.R. Burbano and M.A.C. Smith
Apolipoproteins have an important role in lipid metabolism and transport. Polymorphisms in the APOA1/C3/A4/A5 gene cluster have been associated with lipid alterations and cardiovascular diseases. We investigated APOA1 XmnI, APOA5 S19W, and APOA5 -1131T>C polymorphisms in 377 individuals from a cohort of a longitudinal Brazilian elderly study. Allele fr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.7
- DOI:
- 10.4238/2013.February.28.7
Genetic diversity studies in pea (Pisum sativum L.) using simple sequence repeat markers
Authors: P. Kumari, N. Basal, A.K. Singh, V.P. Rai, C.P. Srivastava and P.K. Singh
The genetic diversity among 28 pea (Pisum sativum L.) genotypes was analyzed using 32 simple sequence repeat markers. A total of 44 polymorphic bands, with an average of 2.1 bands per primer, were obtained. The polymorphism information content ranged from 0.657 to 0.309 with an average of 0.493. The variation in genetic diversity among these cultivars ran.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.13.12
- DOI:
- 10.4238/2013.March.13.12
Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis
Authors: G.J. Suo and Z.X. Zhao
We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bas.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.1
- DOI:
- 10.4238/2013.September.19.1