Polymorphism
Interethnic variation of the MMP-9 microsatellite in Amerindian and Mexican Mestizo populations: considerations for genetic association studies
Authors: R. Camacho-Mejorado, G. Noris, C. Santana, J.J. MagaÃ?±a,A. Majluf-Cruz, J. Arellano-Galindo, A. De la PeÃ?±a, J. HernÃ?¡ndez-JuÃ?¡rez, E.S. CalderÃ?³n-Aranda, M.A. Meraz-RÃ?Âos and R. GÃ?³mez
We studied the interethnic variation of the MMP-9 microsatellite in the Mestizo and Amerindian populations using blood samples collected from 435 healthy unrelated individuals from the Central Valley of Mexico. DNA samples were genotyped using the -90 (CA)12-27 repeat near the MMP transcriptional start site using capillary ele.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.24
- DOI:
- 10.4238/2015.March.31.24
A 425 T>C polymorphism in complement C7 association with resistance to Aeromonas hydrophila in grass carp
Authors: Y.B. Shen, J.B. Zhang, J.J. Fu, X.Y. Xu, J.L. Li R.Q. Wang and Y.F. Xuan
Aeromonas hydrophila, a widespread bacterium in the aquatic environment, causes hemorrhagic septicemia in fish. In the last decade, the disease has caused mass mortalities and tremendous economic loss in cultured fish. The complement component C7 is a terminal component of complement that interacts in a sequence of polymerizat.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15014526
- DOI:
- 10.4238/gmr.15014526
Abnormal hemoglobin phenotypes in carriers of mild anemia in Latin America
Authors: P.J.A. Zamaro and C.R. Bonini-Domingos
We looked for abnormal hemoglobins in blood samples sent for diagnosis of anemia. Identification of the hemoglobins was made using electrophoretic, chromatographic and molecular procedures. The 2020 blood samples were of patients from various regions of Brazil and from some other Latin American countries. Among the abnormal he.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr721
- DOI:
- 10.4238/vol9-1gmr721
Efficient human paternity testing with a panel of 40 short insertion-deletion polymorphisms
Authors: J.R. Pimenta and S.D.J. Pena
We developed a panel of 40 multiplexed short insertion-deletion (indel) polymorphic loci with widespread chromosomal locations and allele frequencies close to 0.50 in the European population. We genotyped these markers in 360 unrelated self-classified White Brazilians and 50 mother-child-probable father trios with proven pater.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr838
- DOI:
- 10.4238/vol9-1gmr838
Association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk in a Chinese population
Authors: X.F. Li, X.Q. Jiang, J.W. Zhang and Y.J. Jia
The association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk has not been investigated. In this hospital-based case-control study, we analyzed 256 patients with cervical cancer and 250 healthy controls. Pearson chi-square test was used to examine differences in the distribution of genotype.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016357
- DOI:
- 10.4238/gmr.15016357
Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population
Authors: H. Zhao, H.W. Zhang, T. Zhang and X.M. Gu
ABSTRACT. In the present study, we aimed to investigate the association between the TNF-α -308G>A polymorphism and the risk of esophageal cancer in a Han Chinese population. The case group included 342 patients with esophageal cancer and the control group comprised 300 healthy individuals. The TNF-α -308G>A p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025866
- DOI:
- 10.4238/gmr.15025866
Association of glutathione S-transferase (GST) genetic polymorphisms with treatment outcome of cisplatin-based chemotherapy for advanced non-small cell lung cancer in a Chinese population
Authors: H.L. Xiao, Z.T. Yang, F. Han and H.X. Wei
The aim of this study was to evaluate the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the chemotherapy response and overall survival of advanced NSCLC. Two hundred and sixty-two patients with histologically confirmed advanced NSCLC (inoperable TNM stages IIIA, IIIB, and IV) wer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027320
- DOI:
- 10.4238/gmr.15027320
Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population
Authors: L.J. Liu, X.Y. Zhang, N. He K Liu, X.G. Shi, T. Feng, T.T. Geng, D.Y. Yuan, L.L. Kangand T.B. Jin
Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027381
- DOI:
- 10.4238/gmr.15027381
Association of C/T polymorphism in intron 14 of the dopamine transporter gene (rs40184) with major depression in a northeastern Thai population
Authors: N. Pattarachotanant, T. Sritharathikhun, S. Suttirat and T. Tencomnao
Several lines of evidence suggest that the dopaminergic system is involved in the pathophysiology of major depressive disorder (MDD). Since the dopamine transporter (DAT1, also known as SLC6A3), mediates the active reuptake of dopamine from the synapses and thereby plays a vital role in the regulation of dopaminergic neurotran.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr757
- DOI:
- 10.4238/vol9-1gmr757
Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women
Authors: J.F. Song, Z.Z. Jing, W. Hu and Y.X. Su
Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteo.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.4
- DOI:
- 10.4238/2013.September.3.4