Polymorphism
Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang
Authors: D.W. Feng, R.L. Ma, H. Guo, J. He, Y.Z. Yan, Muratbek, Q. Niu,S.G. Li, D.S. Rui, F. Sun, M. Zhang, J.Y. Zhang, Y.S. Ding, J.M. Liu, K. Wang and S.X. Guo
The aim of this study was to investigate the potential association between apolipoprotein A1 (APOA1) gene rs670, rs5069, and rs2070665 polymorphisms and dyslipidemia in the Kazakh population of Xinjiang, China. Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) was used to identify APOA.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028094
- DOI:
- 10.4238/gmr.15028094
Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma
Authors: L.H. Zhang, B.B. Hao, C.Y. Zhang, X.Z. Dai and F. Zhang
Hepatocellular carcinoma is one of the most common malignant tumors worldwide; it is estimated that there were 782,000 new cases in 2012. MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating oncogenes and tumor suppressors. We investigated the role of miR-146a, miR-196a2, and miR-499 polymorphisms in the r.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038582
- DOI:
- 10.4238/gmr.15038582
Molecular epidemiology of HFE gene polymorphic variants (C282Y, H63D and S65C) in the population of EspÃ?Ârito Santo, Brazil
Authors: L.N.R. Alves, E.V.W. Santos, E. Stur, A.M.A. Silva Conforti and I.D. Louro
Hereditary hemochromatosis (HH) is an autosomal recessive disorder that leads to progressive iron accumulation and may cause cirrhosis, hepatocellular carcinoma, diabetes, and heart failure. Most cases of HH have been linked to mutations in genes associated with iron homeostasis. There have been three major variants in the hig.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028189
- DOI:
- 10.4238/gmr.15028189
Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran
Authors: M. Hashemi, A.K. Moazeni-Roodi, A. Fazaeli, M. Sandoughi, G.R. Bardestani, D.M. Kordi-Tamandani and S. Ghavami
Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr728
- DOI:
- 10.4238/vol9-1gmr728
Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining
Authors: L. An, H. Xia, P. Zhou and L. Hua
Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028639
- DOI:
- 10.4238/gmr.15028639
Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon
Authors: E.B. Machado, B.B. Souza, R.C. Guimar�£es, J.S.N. Azevedo, E.C. Gon�§alves, H.F.L. Ribeiro, S.T. Rolim Filho, E. Silva Filho
Buffalo farming in Brazil is increasing, as is the challenge of identifying molecular markers that will improve productivity. Therefore, the aim of this study was to analyze single nucleotide polymorphisms of the receptor gene for the hormone melatonin in buffaloes from northern Brazil by polymerase chain reactions (PCRs) and .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027960
- DOI:
- 10.4238/gmr.15027960
Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus
Authors: J.R. Lin, H.H. Qin, Y. Wang, J. Liang and J.H. Xu
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory react.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028007
- DOI:
- 10.4238/gmr.15028007
Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma
Authors: M.W. Peng, S.Q. Lu, J. Liu and C.Y. Dong
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain r.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017984
- DOI:
- 10.4238/gmr.15017984
Genetic diversity in the germplasm of black pepper determined by EST-SSR markers
Authors: B.D. Wu, R. Fan, L.S. Hu, H.S. Wu and C.Y. Hao
This study aimed to assess genetic diversity in the germplasm of black pepper from around the world using SSR markers from EST. In total, 13 markers were selected and successfully amplified the target loci across the black pepper germplasm. All the EST-SSR markers showed high levels of polymorphisms with an average polymorphis.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15018099
- DOI:
- 10.4238/gmr.15018099
Analysis of correlations between coronary heart disease and haplotypes of the angiotensin II receptor type 1 (AGTR1) gene
Authors: L.J. Duan and X.D. Wang
This study aimed to explore correlations between haplotypes of the angiotensin II receptor type 1 (AGTR1) gene and coronary heart disease (CHD). In total, 204 patients with CHD and 206 healthy controls were genotyped using denaturing high-performance liquid chromatography between 2008 and 2014. Five polymorphic loci were found.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017457
- DOI:
- 10.4238/gmr.15017457