Polymorphism
Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population
Authors: C. Ronpirin, T. Tencomnao and J. Wongpiyabovorn
Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic pa.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr718
- DOI:
- 10.4238/vol9-1gmr718
CYP1A2-163C/A (rs762551) polymorphism and bladder cancer risk: a case-control study
Authors: Y.L. Song, L. Wang, J.C. Ren and Z.H. Xu
To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differen.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026298
- DOI:
- 10.4238/gmr.15026298
Relationship between NRAMP1 gene polymorphism and efficacy of BCG vaccine in a helminth-infected population
Authors: A.A. Badawy, R.S. Yahya, S.I. Awad, G.A. Al-Sawah and N.A. Kizilbash
Infection of mothers with schistosomiasis and filariasis has been shown to influence infant responses to neonatal Bacille Calmette-Guérin (BCG) immunization. The genetic makeup of infants is also considered an important determinant for the activity of BCG vaccine. The effect of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymo.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.30.4
- DOI:
- 10.4238/2013.January.30.4
A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer
Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu
The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.22
- DOI:
- 10.4238/2013.January.4.22
Genetic variability of ERCC1 and ERCC2 genes involved in the nucleotide excision repair pathway influences the treatment outcome of gastric cancer
Authors: D.L. Zheng, G.D. Tang, Y.N. Chen, T. Zhang and M.B. Qin
We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platin.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027384
- DOI:
- 10.4238/gmr.15027384
TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis
Authors: X.P. Lu, G.N. Hu, J.Q. Du and H.Q. Li
Numerous studies have evaluated the association between TCF7L2 gene polymorphisms (rs12255372 and rs7903146) and breast cancer risk. However, the results have been inconsistent. Therefore, in the current study, we performed a meta-analysis. A systematically literature search of the PubMed and EMBASE databases was conducted in November 2013, and the refere.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.16
- DOI:
- 10.4238/2015.March.31.16
Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk
Authors: C.X. Zhou and J.H. Zhao
Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We s.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.17
- DOI:
- 10.4238/2015.March.31.17
CASP-9 gene functional polymorphisms and cancer risk: a large-scale association study plus meta-analysis
Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu
We investigated the association between CASP-9 polymorphisms and susceptibility to neoplasm. Fourteen studies with a total of 2733 neoplasm cases and 3352 healthy controls were included. Meta-analysis showed that the rs4645981*T allele and the rs4645981*T allele carrier were positively associated with neoplasm susceptibility [odds ratio (OR) = 1.43, 95% c.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.22
- DOI:
- 10.4238/2013.February.28.22
Association of the IL-4R Q576R polymorphism and asthma in the Chinese Han population: A meta-analysis
Authors: Z.Y. Huang, B.J. Cheng, G.J. Cai and B.F. Zhang
The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated th.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.21
- DOI:
- 10.4238/2015.March.31.21
Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer
Authors: S. Chen, X.C. Zhu, Y.L. Liu, C. Wang and K.G. Zhang
We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038342
- DOI:
- 10.4238/gmr.15038342