Polymorphism
Meta-analysis of TAFI polymorphisms and risk of cardiovascular and cerebrovascular diseases
Authors: S.W. Wang, H.H. Zhang, C.Y. Dong and H.H. Sun
Cardiovascular and cerebrovascular diseases (CCVDs) are common and have high rates of morbidity, mortality, and recurrence. Thrombin-activatable fibrinolysis inhibitor (TAFI) is also known as carboxypeptidase B2 and is encoded by the CPB2 gene; CPB2 polymorphisms have been explored in a variety of studies, but their correlatio.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026718
- DOI:
- 10.4238/gmr.15026718
135G/C polymorphism in the RAD51 gene and acute myeloid leukemia risk: a meta-analysis
Authors: L. Wu, Z.G. Long and Z.S. Dai
Numerous studies have evaluated the association between the 135G/C polymorphism in the RAD51 gene and risk of acute myeloid leukemia (AML), but the results have been inconsistent. The aim of this study is to precisely examine the association between the 135G/C polymorphism in the RAD51 gene and AML risk through a meta-analysis.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027383
- DOI:
- 10.4238/gmr.15027383
Frequency of TLR4 (1063A/G and 1363C/T) polymorphisms in healthy and HIV-infected Omani individuals and their relationship to viral load and T cell count
Authors: E.A. Said, F. Al-Yafei, F. Zadjali, M.S. Al-Balushi, S.S. Hasson, S.H. Al-Mahroqi, C.Y. Koh, K. Al-Naamani, J.Z. Al-Busaidi, M.A. Idris, A. Balkhair and A.A. Al-Jabri
Toll-like receptors (TLRs) are essential elements of the innate immune response to different infections including the infection with human immunodeficiency virus (HIV). Single nucleotide polymorphisms (SNPs) in TLRs such as TLR4 1063A/G and 1363C/T have been found to be associated with changes in CD4 count, viral load (VL), an.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027671
- DOI:
- 10.4238/gmr.15027671
MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation
Authors: Y. Yang, L.J. Yang, M.Z. Deng, Y.Y. Luo, S. Wu, L. Xiong, D. Wang,Y. Liu and H. Liu
Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochra.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027615
- DOI:
- 10.4238/gmr.15027615
Association of lipase lipoprotein polymorphisms with high-density lipoprotein and triglycerides in elderly men
Authors: L.M.Q. Ara�ºjo, M.S. Cendoroglo, C.O. Gigek, E.S. Chen and M. de A.C. Smith
Lipoprotein lipase is essential for triglyceride hydrolysis. The polymorphisms S447X in exon 9 and HindIII in intron 8 have been associated with lower triglyceride levels and lower cardiovascular risk in adult men. We examined the association of these lipoprotein lipase polymorphisms with high-density lipoprotein (HDL) and tri.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr689
- DOI:
- 10.4238/vol9-1gmr689
Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation
Authors: X.X. Zhang, R.J. Bian, J. Wang and Q.Y. Zhang
Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphism.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027599
- DOI:
- 10.4238/gmr.15027599
Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients
Authors: A. Maver, I. Medica, B. Salobir, M. Tercelj and B. Peterlin
Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology a.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr682
- DOI:
- 10.4238/vol9-1gmr682
Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis
Authors: Y. Yang, Y.Y. Luo, S. Wu, Y.D. Tang, X.D. Rao, L. Xiong, M. Tan, M.Z. Deng and H. Liu
Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of Pub.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027631
- DOI:
- 10.4238/gmr.15027631
Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients
Authors: H.X. Peng, X. Xu, R. Yang, Y.M. Chu, D.M. Yang, Y. Xu, F.L. Zhou, W.Z. Ma, X.J. Zhang, M. Guan, Z.H. Yang and Z.D. Jin
Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese pati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027689
- DOI:
- 10.4238/gmr.15027689
Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients
Authors: M. Taheri, F. Mahjoubi and R. Omranipour
One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports ma.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr669
- DOI:
- 10.4238/vol9-1gmr669