Polymorphism
Single-nucleotide polymorphism of the pri-miR-34b/c gene is not associated with susceptibility to congenital heart disease in the Han Chinese population
Authors: Y.-M. Liu, Y. Wang, W. Peng, Z. Wu, X.-H. Wang, M.-L. Wang, W. Wang, J. Sun, Z.-D. Zhang and X.-M. Mo
Recent evidence has shown that the microRNA polymorphism may play an important role in the susceptibility to congenital heart disease (CHD). A potentially functional SNP rs4938723 (T>C) in the promoter region of pri-miR-34b/c might affect transcription factor GATA binding and therefore pri-miR-34b/c expression. We genotyped the pri-miR-34b/c polymorphi.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.9
- DOI:
- 10.4238/2013.August.12.9
IL-10 promoter SNPs and susceptibility to leprosy in ethnic groups from southwest China
Authors: X.H. Chen, J.H. Xiong, Y. Ning, Y. Wen, J. Liu, C. Mao, X.M. Weng and J.C. Gu
The purpose of this study was to determine whether interleukin-10 (IL-10) promoter polymorphisms are associated with leprosy or their subtypes in ethnic groups from southwest China. Genotyping using TaqMan® SNP Genotyping Master Mix and ABI 7500 real-time PCR system was performed for IL-10 T3575A, G2849A, C2763A, A1082G, C.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.3
- DOI:
- 10.4238/2013.August.12.3
MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis
Authors: J.Z. Guan, M. Wu, Y.Z. Xiao, J.S. Zhou and Z.D. Wang
Numerous studies have evaluated the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis of the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. Only seve.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.1
- DOI:
- 10.4238/2014.September.12.1
Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population
Authors: Y. Cao, J. Hu, Y. Fang, Q. Chen and H. Li
Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Through genotyping the rs895819 SNP in 254 colorectal cance.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.8
- DOI:
- 10.4238/2014.September.12.8
Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer
Authors: X. Tan, Y.Y. Wang, X.Y. Chen, L. Xian, J.J. Guo1, G.B. Liang and M.W. Chen
The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-a.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.10
- DOI:
- 10.4238/2014.September.12.10
Association between the FCGR2A gene H131R polymorphism and risk of Kawasaki disease: a meta-analysis
Authors: L. Lin, S.Y. Wang, S.B. Yang and F.C. Xiao
Several previous studies have investigated whether the FCGR2A gene H131R polymorphism confers an increased risk of Kawasaki disease (KD), but conflicting results have been reported. To further explore the association of this polymorphism with KD susceptibility, we performed an extensive search of relevant studies and conducted a meta-analysis to obtain a .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.12
- DOI:
- 10.4238/2015.June.9.12
Novel polymorphic microsatellite markers in Odontobutis potamophila
Authors: Y.B. Shen, D. Li, J.L. Li, R.Q. Wang and Y.F. Xuan
We characterized 16 novel polymorphic loci isolated from a partial genomic DNA library of Odontobutis potamophila enriched for CA repeats. We tested the variability of these microsatellites on 51 unrelated individuals collected in China. All loci were polymorphic. The average allele number was 14.6 per locus, ranging from 2 to 27. The observed heterozygos.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.13
- DOI:
- 10.4238/2015.June.9.13
Distribution of CXCR2 +1208 T/C gene polymorphisms in relation to opportunistic infections among HIV-infected patients in Limpopo Province, South Africa
Authors: A. Samie, G.A. Dzhivhuho and T.C. Nangammbi
Interleukin 8 (IL-8) is a chemokine produced by macrophages and other cell types, including epithelial cells, and its receptor is CXCR2. IL-8 plays an important role in the initiation and amplification of inflammatory diseases, including opportunistic infections. With the advent of human immunodeficiency virus (HIV) and acquir.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.13
- DOI:
- 10.4238/2014.September.12.13
Polymorphisms in the PPAR�³ gene and their association with metabolic syndrome in Uyghurs and Kazakhs from Xinjiang, China
Authors: J. Chen, R.L. Ma, H. Guo, Y.S. Ding, J.Y. Zhang, J.M. Liu, M. Kerm, M. Zhang, S.Z. Xu, S.G. Li and S.X. Guo
We investigated the association between polymorphisms rs1801282 and rs3856806 of the PPARγ gene and metabolic syndrome (MS) among Uyghurs and Kazakhs. Mass spectrometry techniques were used to detect the PPARγ genotypes rs1801282 and rs3856806 in 987 subjects, CC genotype and C allele frequencies were 83.6 and 91.7%, respectively, at rs1801282.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.1
- DOI:
- 10.4238/2015.June.11.1
Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population
Authors: P. Qi, L. Wang, B. Zhou, W.J. Yao, S. Xu, Y. Zhou and Z.B. Xie
Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide poly.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.2
- DOI:
- 10.4238/2015.June.11.2