Polymorphism
Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women
Authors: D.P. Shang, H.Y. Lian, D.P. Fu, J. Wu, S.S. Hou and J.M. Lu
The purpose of this study was to evaluate single nucleotide polymorphism (SNP) variants of the estrogen receptor 1 gene (ESR1) at rs2234693 and rs9340799, as well as to investigate the relationship between ESR gene polymorphisms and postmenopausal osteoporosis (OP) of the spine in Chinese women. We recruited 198 postmenopausal.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028106
- DOI:
- 10.4238/gmr.15028106
Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, S. Nissar, S. Mudassar and M.A. Siddiqi
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism ha.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1067
- DOI:
- 10.4238/vol10-2gmr1067
Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses
Authors: A. El Samanoudy, R. Monir, A. Badawy, L. Ibrahim, K. Farag, S. El Baz, D. Alenizi and A. Alenezy
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. In Egypt, the incidence of HCC has doubled over the last decade. Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C)/thymidine (T) .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.15
- DOI:
- 10.4238/2014.September.29.15
Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility
Authors: Z.Y. Huang, B.J. Cheng, Y. Wan and C. Zhou
The results of previous epidemiological studies exploring the relationship between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to pediatric asthma are not consistent. Therefore, we have performed a systematic review and meta-analysis to provide a more convincing conclusion. Odds ratios (OR) with their 95% .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028320
- DOI:
- 10.4238/gmr.15028320
Correlation between polymorphisms in the glucocorticoid receptor gene NR3C1 and susceptibility to asthma in a Chinese population from the Henan Province
Authors: Z. Cheng, L.L. Dai, Q. Liu, M. Liu, Q. Wang, P.F. Li, H. Wang, L.Q. Jia and L. An
The aim of this study was to investigate the association between four single nucleotide polymorphisms in NR3C1 (Tth111I, BclI, ER22/23EK, and N363S), which encode the glucocorticoid receptor, and asthma susceptibility in patients from the Henan Province of China. Three hundred and twenty-eight patients with asthma and 60 healt.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028507
- DOI:
- 10.4238/gmr.15028507
Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis
Authors: J.X. Liang, W. Gao, Y. Liang and X.M. Zhou
N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.21
- DOI:
- 10.4238/2015.December.16.21
Meta-analysis of the TNF-�±-308G/A polymorphism and vitiligo risk
Authors: G. Nie, J.H. Qi, C.W. Huang, T. Yang, N. Shi and Y.J. Chen
Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.30
- DOI:
- 10.4238/2015.December.16.30
Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis
Authors: G.X. Jin, J.Z. Duan, W.L. Guo, L. Li, S.Q. Cui and H. Wang
We made a Human Genome Epidemiology review and meta-analysis to examine a possible association between interleukin-1 receptor antagonist (IL-1RN) polymorphisms and susceptibility to ankylosing spondylitis (AS). Studies of IL-1RN polymorphisms and susceptibility to AS were found by searching the Pubmed, Cochrane library, Embase, Web of Science, Springerlin.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.21.3
- DOI:
- 10.4238/2013.May.21.3
IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population
Authors: S.X. Yang, F. Chen, J.W. Zhang, Z.Q. Sun and B.P. Chen
IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of pol.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027553
- DOI:
- 10.4238/gmr.15027553
Association between the interleukin-1�² gene -511C/T polymorphism and ischemic stroke: an updated meta-analysis
Authors: W. Yan, Z.Y. Chen, J.Q. Chen and H.M. Chen
Numerous studies have investigated the relationship between the interleukin-1β gene (IL1B) -511C/T polymorphism and ischemic stroke (IS) risk. However, the results are inconsistent. We performed this meta-analysis of all available case-control studies that evaluated the relationship between the IL1B -511C/T polymorphism a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027580
- DOI:
- 10.4238/gmr.15027580