Polymorphism
Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group
Authors: S.H. Yildiz, M. Ozdemir Erdogan, M. Solak, O. Eser, E.S. Ar�±kan Terzi, B. Eser, V. Kocaba�� and A. Aslan
The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. In this study, the genotype distribution of t.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028051
- DOI:
- 10.4238/gmr.15028051
Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population
Authors: X.Y. Yi, Q. Zhou, J. Lin, L.F. Chi and W.Z. Chi
We made a case-control study to investigate a possible association between ALOX5AP-SG13S114A/T, COX-2-765G/C, and COX-1-50C/T polymorphisms with cerebral infarction in a Chinese population. A total of 411 cases with cerebral infarction were included; 411 controls matched for age, gender, and risk factors were also selected. The ALOX5AP-SG13S114A/T (rs1050.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.6
- DOI:
- 10.4238/2013.May.14.6
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Authors: S.H. Ma, F.H. Ling, Y.X. Sun, S.F. Chen and Z. Li
We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028066
- DOI:
- 10.4238/gmr.15028066
KLK1 A1789G gene polymorphism and the risk of coronary artery stenosis in the Chinese population
Authors: Q.D. Li, F.J. Li, X.C. Liu and H. Jiang
Previous reports have shown that polymorphism of the human tissue kallikrein 1 (KLK1) A1789G gene is associated with susceptibility to hypertension. The current study aimed to confirm the association between the polymorphism in KLK1 and coronary artery stenosis (CAS). A total of 458 patients with CAS and 482 controls were used in a case-control study carr.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.4
- DOI:
- 10.4238/2013.May.14.4
Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population
Authors: L.J. Wang, H.T. Wang and X.X. Wang
We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014... Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028080
- DOI:
- 10.4238/gmr.15028080
Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy
Authors: M.M. Silva, C.O. Da Fonseca, R. Moura-Neto, J.F. Carvalho, T. Quirico-Santos and M.G. Carvalho
GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.14.2
- DOI:
- 10.4238/2013.May.14.2
3'-UTR polymorphism (rs10434) in the VEGF gene is associated with B-CLL in a Chinese population
Authors: L.X. Zhu,X.J. Ye,Y.G. Wang,J.J. Zhu, W.Z. Xie,Y.M. Zhao and X.Y. Lai
We investigated the relationship between a VEGF genetic polymorphism and B cell chronic lymphocytic leukemia (B-CLL). A total of 102 patients with B-CLL and 124 healthy subjects were included in this study. All individuals were typed for the rs10434 in the vascular endothelial growth factor (VEGF) gene using the TaqMan technique. We found that the A allel.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.23
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.23
Single nucleotide polymorphism analysis of the endopolygalacturonase gene in peach and its potential use in crossbreeding programs
Authors: Y. Jiao,R. Ma and M. Yu
Single nucleotide polymorphisms (SNPs) are the most abundant sequence variations found in plant genomes and are widely used as molecular genetic markers in genetic diversity studies and crossbreeding programs. In this study, we examined 113 DNA sequences of the endopolygalacturonase (endo-PG) gene from 67 peach accessions and found a total of 56 SNPs and .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.24
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.24
Transferability of retrotransposon primers derived from Persimmon (Diospyros kaki Thunb.) across other plant species
Authors: X.Y. Du, Q.N. Hu, Q.L. Zhang, Y.B. Wang and Z.R. Luo
Retrotransposon-based molecular markers are powerful molecular tools. However, these markers are not readily available due to the difficulty in obtaining species-specific retrotransposon primers. Although recent techniques enabling the rapid isolation of retrotransposon sequences have facilitated primer development, this process nonetheless remains time-c.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.6.2
- DOI:
- 10.4238/2013.June.6.2
Association study between matrix metalloproteinase-9 gene (MMP9) polymorphisms and the risk of Henoch-Sch�¶nlein purpura in children
Authors: E.D. Xu, Y.F. Xiao, J.J. Wang and L. Dong
Henoch-Schönlein purpura nephritis (HSPN), the most serious long-term complication of Henoch-Schönlein purpura, is one of the most common renal diseases in children. Matrix metalloproteinase-9 (MMP-9) is implicated in the pathogenesis of renal diseases. Genomic DNA was isolated from the venous blood leukocytes of 220.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028095
- DOI:
- 10.4238/gmr.15028095